2021
LGI1 governs neuritin-mediated resilience to chronic stress
Lee S, Kim N, Choi M, Ko S, Wang S, Jo H, Seo J, Kim Y, Kim H, Lee H, Kim J, Son H. LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology Of Stress 2021, 15: 100373. PMID: 34401409, PMCID: PMC8350063, DOI: 10.1016/j.ynstr.2021.100373.Peer-Reviewed Original ResearchLeucine-rich glioma-inactivated protein 1Chronic unpredictable stressLGI1 expressionAntidepressant-like behaviorHippocampus of miceHistone deacetylase 5 (HDAC5) phosphorylationDevelopment of CNSInsulin receptor inhibitorNeuronal atrophyFlox/Unpredictable stressReceptor inhibitorsChronic stressNeuritinHDAC5 phosphorylationProtein 1Pathological depressionMetastasis suppressorEndogenous proteinsNeurite outgrowthMiceDepressionStress resilienceCritical roleExpression
2014
Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
Choi M, Ko SY, Lee IY, Wang SE, Lee SH, Oh DH, Kim YS, Son H. Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300. Biochemical And Biophysical Research Communications 2014, 446: 79-84. PMID: 24607903, DOI: 10.1016/j.bbrc.2014.02.066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedDisks Large Homolog 4 ProteinE1A-Associated p300 ProteinEpigenesis, GeneticErythropoietinIntracellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMembrane ProteinsNerve Tissue ProteinsNeuritesNeurogenesisNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsSTAT3 Transcription FactorTranscriptional ActivationTumor Suppressor Protein p53Up-RegulationConceptsNeuronal differentiationNeuronal spine formationCBP/p300E1A-binding proteinSpine formationTreatment of cellsEpigenetic modificationsTranscription factorsSubsequent transactivationTarget genesTransactivation activityGene expressionMolecular mechanismsImportant medical implicationsLength of neuritesP53 acetylationNeurite outgrowthGrowth-associated protein 43TransactivationAcetylationMedical implicationsDifferentiationProtein 43Spine densityNeuropsychiatric disorders