2019
Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, Son H. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Experimental Neurobiology 2019, 28: 537-546. PMID: 31495082, PMCID: PMC6751865, DOI: 10.5607/en.2019.28.4.537.Peer-Reviewed Original ResearchPlasticity-related genesSynaptic plasticity-related genesLysine N-methyltransferase 2Cellular oxidative stress responseDepression-like behaviorSilent information regulator 2Oxidative stress responseDownregulation of SIRT2SIRT2 expressionTranscriptional silencingKnockdown of SIRT2Protein stabilityRegulator 2Target proteinsChronic stressStress responseHippocampus-dependent cognitive functionDependent deacetylaseGenesBiochemical analysisStress-induced decreaseSIRT2Reduces ExpressionExpressionMood disordersEpigenetic therapy of Prader–Willi syndrome
Kim Y, Wang SE, Jiang YH. Epigenetic therapy of Prader–Willi syndrome. Translational Research 2019, 208: 105-118. PMID: 30904443, PMCID: PMC6527448, DOI: 10.1016/j.trsl.2019.02.012.Peer-Reviewed Original ResearchConceptsPWS mouse modelEpigenetic-based therapiesMaternal chromosomesImprinted gene regulationEHMT2/G9aLysine 9 methyltransferasePatient-derived fibroblastsPrader-Willi syndromeGene regulationMethyltransferase SETDB1Epigenetic mechanismsSmall molecule librariesPWS genesHigh-content screeningSame genePerinatal lethalityEpigenetic therapyFusion proteinMolecular mechanismsG9a inhibitorChromosomesSNORD116 clusterGenesMolecular defectsPatient iPSC
2015
Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats
Choi M, Lee SH, Wang SE, Ko SY, Song M, Choi JS, Kim YS, Duman RS, Son H. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15755-15760. PMID: 26647181, PMCID: PMC4697416, DOI: 10.1073/pnas.1513913112.Peer-Reviewed Original ResearchConceptsHistone deacetylase 5Myocyte enhancer factor 2MEF2 target genesNuclear exportTarget genesTranscriptional activityPhosphorylation-dependent nuclear exportPhosphorylation-defective mutantProtein kinase DHistone deacetylase 5 (HDAC5) phosphorylationMEF2 transcriptional activityAntidepressant-like effectsCalcium/calmodulin kinase IICalmodulin kinase IIKinase DKinase IIMolecular mechanismsNovel roleRapid antidepressant-like effectsDependent pathwayAction of ketamineFactor 2Rat hippocampal neuronsGenesHippocampal knockdown