Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 18187-18192. PMID: 17991774, PMCID: PMC2084318, DOI: 10.1073/pnas.0708968104.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis B viral infectionB virusImmune responseAcute hepatitisNKT cellsLiver injuryViral infectionCell-mediated immune responsesBlockade of NKG2DPrimary HBV infectionAcute liver injuryAcute immune responseTransgenic mouse modelPotential therapeutic targetNKG2D-ligand interactionChronic hepatitisHBV infectionAlpha-GalCerNatural killerHepatic pathologyViral antigensMouse modelTherapeutic targetHepatitis