2024
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P. Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy. Adv Sci (Weinh) 2024, 11: e2401061. PMID: 38569519, DOI: 10.1002/advs.202401061.Peer-Reviewed Original ResearchFatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
Peng H, Xin S, Pfeiffer S, Müller C, Merl-Pham J, Hauck S, Harter P, Spitzer D, Devraj K, Varynskyi B, Arzberger T, Momma S, Schick J. Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia. Cell Death & Disease 2024, 15: 286. PMID: 38653992, PMCID: PMC11039673, DOI: 10.1038/s41419-024-06681-y.Peer-Reviewed Original ResearchConceptsFatty acid binding protein 5Cell deathFunction biomarkersProtein 5Death in vitroPositive-feedback loopFerroptotic cell deathLipidomics assaysIndicators of ferroptosisClinical investigationFerroptosis sensitivityWidespread cell deathEctopic expressionMarker antigensReactive speciesCerebral hypoxiaDamaged neuronsProtein dynamicsDeath processCell surfaceHuman pathophysiologyPostmortem patientsIron accumulationInvolvement of lipidsNeurodegenerative diseasesA multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer.
Bao X, Li Q, Chen D, Dai X, Liu C, Tian W, Zhang H, Jin Y, Wang Y, Cheng J, Lai C, Ye C, Xin S, Li X, Su G, Ding Y, Xiong Y, Xie J, Tano V, Wang Y, Fu W, Deng S, Fang W, Sheng J, Ruan J, Zhao P. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep Med 2024, 5: 101399. PMID: 38307032, DOI: 10.1016/j.xcrm.2024.101399.Peer-Reviewed Original ResearchGenome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy.
Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. BioRxiv 2024 PMID: 38293095, DOI: 10.1101/2024.01.14.575614.Peer-Reviewed Original Research
2023
An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis.
Bao X, Wang D, Dai X, Liu C, Zhang H, Jin Y, Tong Z, Li B, Tong C, Xin S, Li X, Wang Y, Liu L, Zhu X, Fu Q, Zheng Y, Deng J, Tian W, Guo T, Zhao P, Chen W, Fang W. An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis. Cell Rep Med 2023, 4: 100987. PMID: 36990096, DOI: 10.1016/j.xcrm.2023.100987.Peer-Reviewed Original ResearchPUFAs dictate the balance of power in ferroptosis
Xin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.Peer-Reviewed Original ResearchConceptsLethal lipid peroxidationIron-dependent formFerroptosis susceptibilityLipid remodelingFerroptosis sensitivityFatty acidsFerroptosis resistanceLipid transportersTumor suppressionMembrane lipidsPhospholipid transporterCell deathFerroptosis inductionBiochemical processesFerroptosisLipid metabolismReceptor alphaLipid componentsTransportersPeroxisome proliferatorLipid peroxidationCholesterol estersRegulatorAcidPPARAMassively parallel knock-in engineering of human T cells
Dai X, Park J, Du Y, Na Z, Lam S, Chow R, Renauer P, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Massively parallel knock-in engineering of human T cells. Nature Biotechnology 2023, 41: 1239-1255. PMID: 36702900, PMCID: PMC11260498, DOI: 10.1038/s41587-022-01639-x.Peer-Reviewed Original Research
2021
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
Xin S, Mueller C, Pfeiffer S, Kraft V, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck S, Schmitt-Kopplin P, Schick J. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death & Differentiation 2021, 29: 670-686. PMID: 34663908, PMCID: PMC8901757, DOI: 10.1038/s41418-021-00883-z.Peer-Reviewed Original ResearchConceptsCell deathDiverse cellular processesLipid droplet dispersionIron-dependent formKey resistance mechanismNovel tetraspaninCellular processesLipid remodelingFerroptosis resistanceLuminal Ca2Endoplasmic reticulumCellular lipidsCell survivalLipid reservoirsDetoxification pathwaysCancer cell linesLipid elongationBiochemical processesMembrane phospholipidsEther lipidsResistance mechanismsCell linesFerroptosisLipid compartmentsSpeciesEvolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells
Song W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.Peer-Reviewed Original ResearchConceptsComprehensive phylogenetic analysisHallmarks of ferroptosisFunctional divergenceMammalian GPxEarly divergencePhylogenetic analysisFerroptosis protectionMammalian cellsFunctional analysisMembrane lipidsMechanistic similaritiesCell deathFerroptosis inductionMouse fibroblastsAntioxidant systemPlantsUnique mechanismOxidative stressSpeciesFatty acidsFerroptosisGPX4DivergenceCellsGPx
2019
Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature.
Bao X, Shi R, Zhang K, Xin S, Li X, Zhao Y, Wang Y. Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature. Front Oncol 2019, 9: 903. PMID: 31620363, DOI: 10.3389/fonc.2019.00903.Peer-Reviewed Original ResearchPrognostic and Predictive Value of Three DNA Methylation Signatures in Lung Adenocarcinoma.
Wang Y, Deng H, Xin S, Zhang K, Shi R, Bao X. Prognostic and Predictive Value of Three DNA Methylation Signatures in Lung Adenocarcinoma. Front Genet 2019, 10: 349. PMID: 31105737, DOI: 10.3389/fgene.2019.00349.Peer-Reviewed Original ResearchA novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis.
Wang Y, Zhang Q, Gao Z, Xin S, Zhao Y, Zhang K, Shi R, Bao X. A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis. Cancer Cell Int 2019, 19: 100. PMID: 31015800, DOI: 10.1186/s12935-019-0822-1.Peer-Reviewed Original ResearchLow GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas.
Wang Y, Xin S, Zhang K, Shi R, Bao X. Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas. J Oncol 2019, 2019: 1785042. PMID: 30853980, DOI: 10.1155/2019/1785042.Peer-Reviewed Original Research
2017
Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast Oxidation
Li R, Xin S, Tao C, Jin X, Li H. Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast Oxidation. International Journal Of Molecular Sciences 2017, 18: 1346. PMID: 28644407, PMCID: PMC5535839, DOI: 10.3390/ijms18071346.Peer-Reviewed Original ResearchConceptsBY-2 cellsTransgenic tobacco BY-2 cellsTobacco BY-2 cellsCell growthMonodehydroascorbate reductaseDehydroascorbate reductaseCultured tobacco Bright Yellow-2 (BY-2) cellsTobacco Bright Yellow-2 cellsIndole-3-acetic acid (IAA) treatmentTransgenic BY-2 cellsBright Yellow-2 cellsSignificant induced expressionFiber cell elongationSubcellular distribution analysisAscorbate oxidase geneMulticopper oxidase familyAscorbate oxidaseMutant ovulesTransgenic tobaccoWild-type fibersCell elongationSignal peptideTransmembrane regionOxidase genePromotes Cell Growth
2016
Cloning and Functional Analysis of the Promoter of an Ascorbate Oxidase Gene from Gossypium hirsutum
Xin S, Tao C, Li H. Cloning and Functional Analysis of the Promoter of an Ascorbate Oxidase Gene from Gossypium hirsutum. PLOS ONE 2016, 11: e0161695. PMID: 27597995, PMCID: PMC5012575, DOI: 10.1371/journal.pone.0161695.Peer-Reviewed Original Research
1982
Establishing a special education management system--SEMS.
Hayden D, Vance B, Irvin MS. Establishing a special education management system--SEMS. J Learn Disabil 1982, 15: 428-9. PMID: 6759595, DOI: 10.1177/002221948201500712.Peer-Reviewed Original Research