2021
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
Xin S, Mueller C, Pfeiffer S, Kraft V, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck S, Schmitt-Kopplin P, Schick J. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death & Differentiation 2021, 29: 670-686. PMID: 34663908, PMCID: PMC8901757, DOI: 10.1038/s41418-021-00883-z.Peer-Reviewed Original ResearchMeSH KeywordsBiochemical PhenomenaCalciumFerroptosisLipid PeroxidationOxidation-ReductionPhospholipidsConceptsCell deathDiverse cellular processesLipid droplet dispersionIron-dependent formKey resistance mechanismNovel tetraspaninCellular processesLipid remodelingFerroptosis resistanceLuminal Ca2Endoplasmic reticulumCellular lipidsCell survivalLipid reservoirsDetoxification pathwaysCancer cell linesLipid elongationBiochemical processesMembrane phospholipidsEther lipidsResistance mechanismsCell linesFerroptosisLipid compartmentsSpeciesEvolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells
Song W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.Peer-Reviewed Original ResearchConceptsComprehensive phylogenetic analysisHallmarks of ferroptosisFunctional divergenceMammalian GPxEarly divergencePhylogenetic analysisFerroptosis protectionMammalian cellsFunctional analysisMembrane lipidsMechanistic similaritiesCell deathFerroptosis inductionMouse fibroblastsAntioxidant systemPlantsUnique mechanismOxidative stressSpeciesFatty acidsFerroptosisGPX4DivergenceCellsGPx
2017
Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast Oxidation
Li R, Xin S, Tao C, Jin X, Li H. Cotton Ascorbate Oxidase Promotes Cell Growth in Cultured Tobacco Bright Yellow-2 Cells through Generation of Apoplast Oxidation. International Journal Of Molecular Sciences 2017, 18: 1346. PMID: 28644407, PMCID: PMC5535839, DOI: 10.3390/ijms18071346.Peer-Reviewed Original ResearchConceptsBY-2 cellsTransgenic tobacco BY-2 cellsTobacco BY-2 cellsCell growthMonodehydroascorbate reductaseDehydroascorbate reductaseCultured tobacco Bright Yellow-2 (BY-2) cellsTobacco Bright Yellow-2 cellsIndole-3-acetic acid (IAA) treatmentTransgenic BY-2 cellsBright Yellow-2 cellsSignificant induced expressionFiber cell elongationSubcellular distribution analysisAscorbate oxidase geneMulticopper oxidase familyAscorbate oxidaseMutant ovulesTransgenic tobaccoWild-type fibersCell elongationSignal peptideTransmembrane regionOxidase genePromotes Cell Growth