2023
PUFAs dictate the balance of power in ferroptosis
Xin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.Peer-Reviewed Original ResearchConceptsLethal lipid peroxidationIron-dependent formFerroptosis susceptibilityLipid remodelingFerroptosis sensitivityFatty acidsFerroptosis resistanceLipid transportersTumor suppressionMembrane lipidsPhospholipid transporterCell deathFerroptosis inductionBiochemical processesFerroptosisLipid metabolismReceptor alphaLipid componentsTransportersPeroxisome proliferatorLipid peroxidationCholesterol estersRegulatorAcidPPARA
2021
Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells
Song W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.Peer-Reviewed Original ResearchConceptsComprehensive phylogenetic analysisHallmarks of ferroptosisFunctional divergenceMammalian GPxEarly divergencePhylogenetic analysisFerroptosis protectionMammalian cellsFunctional analysisMembrane lipidsMechanistic similaritiesCell deathFerroptosis inductionMouse fibroblastsAntioxidant systemPlantsUnique mechanismOxidative stressSpeciesFatty acidsFerroptosisGPX4DivergenceCellsGPx