Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells
Song W, Xin S, He M, Pfeiffer S, Cao A, Li H, Schick J, Jin X. Evolutionary and functional analyses demonstrate conserved ferroptosis protection by Arabidopsis GPXs in mammalian cells. The FASEB Journal 2021, 35: e21550. PMID: 33960023, DOI: 10.1096/fj.202000856r.Peer-Reviewed Original ResearchConceptsComprehensive phylogenetic analysisHallmarks of ferroptosisFunctional divergenceMammalian GPxEarly divergencePhylogenetic analysisFerroptosis protectionMammalian cellsFunctional analysisMembrane lipidsMechanistic similaritiesCell deathFerroptosis inductionMouse fibroblastsAntioxidant systemPlantsUnique mechanismOxidative stressSpeciesFatty acidsFerroptosisGPX4DivergenceCellsGPx