2023
PUFAs dictate the balance of power in ferroptosis
Xin S, Schick J. PUFAs dictate the balance of power in ferroptosis. Cell Calcium 2023, 110: 102703. PMID: 36773492, DOI: 10.1016/j.ceca.2023.102703.Peer-Reviewed Original ResearchConceptsLethal lipid peroxidationIron-dependent formFerroptosis susceptibilityLipid remodelingFerroptosis sensitivityFatty acidsFerroptosis resistanceLipid transportersTumor suppressionMembrane lipidsPhospholipid transporterCell deathFerroptosis inductionBiochemical processesFerroptosisLipid metabolismReceptor alphaLipid componentsTransportersPeroxisome proliferatorLipid peroxidationCholesterol estersRegulatorAcidPPARA
2021
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
Xin S, Mueller C, Pfeiffer S, Kraft V, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck S, Schmitt-Kopplin P, Schick J. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death & Differentiation 2021, 29: 670-686. PMID: 34663908, PMCID: PMC8901757, DOI: 10.1038/s41418-021-00883-z.Peer-Reviewed Original ResearchConceptsCell deathDiverse cellular processesLipid droplet dispersionIron-dependent formKey resistance mechanismNovel tetraspaninCellular processesLipid remodelingFerroptosis resistanceLuminal Ca2Endoplasmic reticulumCellular lipidsCell survivalLipid reservoirsDetoxification pathwaysCancer cell linesLipid elongationBiochemical processesMembrane phospholipidsEther lipidsResistance mechanismsCell linesFerroptosisLipid compartmentsSpecies