Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation
Sin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, Calkhoven CF, Reinke V, Guryev V, Nollen EA. Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell 2017, 65: 1096-1108.e6. PMID: 28306505, PMCID: PMC5364375, DOI: 10.1016/j.molcel.2017.02.022.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAnimals, Genetically ModifiedBinding SitesCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusCytosolDisease Models, AnimalNeurodegenerative DiseasesPeptidesPromoter Regions, GeneticProtein AggregatesProtein Aggregation, PathologicalProtein BindingRNA InterferenceRNA Polymerase IIIRNA, Small UntranslatedTranscription FactorsTranscription, GeneticConceptsProtein aggregationSmall non-coding RNAsForward genetic screenAggregation-prone proteinsDrivers of aggregationRNA polymerase IIINon-coding RNAsPolyglutamine-expanded huntingtinGenetic screenCellular homeostasisPolyglutamine aggregationAge-related neurodegenerative disordersPolymerase IIIEndogenous proteinsPolyglutamineCellular mechanismsProteinNeurodegenerative disordersCytosolSuch mechanismsAggregationLIRTranscriptionHuntingtinRNA