2017
Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells
Brennand K. Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells. Stem Cell Investigation 2017, 4: 91-91. PMID: 29270417, PMCID: PMC5723749, DOI: 10.21037/sci.2017.10.05.Commentaries, Editorials and LettersNeural progenitor cellsBrain disordersNeural cell fateNeuropsychiatric diseasesStem cellsZika virus infectionPatient genetic variantsCell-derived neuronsPluripotent stem cellsHuman neural cellsCell fateDisease drug discoveryDisease progressionHealthy controlsNeural differentiationVirus infectionMature neuronsParkinson's diseasePhenotypic changesCellular insightsPatient's genotypeZika virusAlzheimer's diseaseBrain tissueNeural proliferation
2015
A guide to generating and using hiPSC derived NPCs for the study of neurological diseases.
Topol A, Tran N, Brennand K. A guide to generating and using hiPSC derived NPCs for the study of neurological diseases. Journal Of Visualized Experiments 2015, e52495. PMID: 25742222, PMCID: PMC4354663, DOI: 10.3791/52495.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsHiPSC neural progenitor cellsRapid genetic screeningPluripotent stem cellsCellular phenotypesDevelopmental eventsMolecular consequencesGene expressionNeurological diseasesFunctional neuronsStem cellsProgenitor cellsOnset of symptomsMolecular factorsFurther differentiationPost-mortem studiesDisease initiationGenetic screeningOxidative stressSymptom onsetDisease progressionHealthy controlsDiseaseCellsPatients