2021
A Distinctive Pattern of Diversity for the TAS2R38 Gene in North Africa
Mourali-Chebil S, Elkamel S, Boussetta S, Pakstis A, Kidd K, Benammar-Elgaaied A, Cherni L. A Distinctive Pattern of Diversity for the TAS2R38 Gene in North Africa. Human Biology 2021, 93: 163-177. PMID: 37733614, DOI: 10.1353/hub.2021.0009.Peer-Reviewed Original ResearchGenetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region
Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L. Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region. Gene 2021, 777: 145466. PMID: 33524518, DOI: 10.1016/j.gene.2021.145466.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfrica, NorthernAllelesBlack PeopleEthnicityFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenomicsGenotypeGenotyping TechniquesHaplotypesHeterozygoteHuman MigrationHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsNorth African populationsGenetic diversitySingle nucleotide polymorphismsGenetic structureAncestral gene poolPeculiar genetic structureLowest average heterozygosityNorth African onesAfrican populationsHigh linkage disequilibriumGenetic driftGenomic regionsAverage heterozygosityGene poolSame locusLinkage disequilibriumDisequilibrium analysisGenetic componentGenesNucleotide polymorphismsLociReceptor geneDiversityHuman populationEuropean populations
2020
Validation of novel forensic DNA markers using multiplex microhaplotype sequencing
Gandotra N, Speed WC, Qin W, Tang Y, Pakstis AJ, Kidd KK, Scharfe C. Validation of novel forensic DNA markers using multiplex microhaplotype sequencing. Forensic Science International Genetics 2020, 47: 102275. PMID: 32305739, PMCID: PMC10131188, DOI: 10.1016/j.fsigen.2020.102275.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsMH lociMultiplex sequencingNovel single nucleotide polymorphismsSmall DNA amountsSingle MiSeq runMultiple single nucleotide polymorphismsHigher effective numberBiogeographic variationDNA markersGenomic sequencesNovel lociGenome ProjectDNA amountMiSeq runDifferent world populationsNucleotide polymorphismsLociSequencingMicrohaplotypesEffective numberDiverse range
2018
Microhaplotypes in forensic genetics
Oldoni F, Kidd KK, Podini D. Microhaplotypes in forensic genetics. Forensic Science International Genetics 2018, 38: 54-69. PMID: 30347322, DOI: 10.1016/j.fsigen.2018.09.009.Peer-Reviewed Original Research
2017
Microhaplotypes for ancestry prediction
Oldoni F, Hart R, Long K, Maddela K, Cisana S, Schanfield M, Wootton S, Chang J, Lagace R, Hasegawa R, Kidd K, Podini D. Microhaplotypes for ancestry prediction. Forensic Science International Genetics Supplement Series 2017, 6: e513-e515. DOI: 10.1016/j.fsigss.2017.09.209.Peer-Reviewed Original ResearchRandom match probabilityAncestry predictionLow mutation rateAllele frequenciesMH allelesMore SNPsParallel sequencingMutation rateAllelic combinationsIon S5Input DNAIon ChefMicrohaplotypesParental haplotypesLociMPS platformsSequencingAllelesMatch probabilityMinor contributorSTR profilesIndividual strands
2016
Proposed nomenclature for microhaplotypes
Kidd KK. Proposed nomenclature for microhaplotypes. Human Genomics 2016, 10: 16. PMID: 27316555, PMCID: PMC4912715, DOI: 10.1186/s40246-016-0078-y.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsHUGO Gene Nomenclature CommitteeGene Nomenclature CommitteeGroup of genesGene familyPopulation geneticsChromosome numberChromosome 1Related genesGenetic markersNucleotide polymorphismsNomenclature CommitteeGenesMicrohaplotypesRootsChromosomesFamilyLociUnique characterStandardized nomenclatureGeneticsNomenclatureSequencePolymorphism
2015
Genetic markers for massively parallel sequencing in forensics
Kidd K, Speed W, Wootton S, Lagace R, Langit R, Haigh E, Chang J, Pakstis A. Genetic markers for massively parallel sequencing in forensics. Forensic Science International Genetics Supplement Series 2015, 5: e677-e679. DOI: 10.1016/j.fsigss.2015.12.004.Peer-Reviewed Original ResearchShort tandem repeat polymorphismsSingle nucleotide polymorphismsParallel sequencingSingle single-nucleotide polymorphismSequence readsMore haplotypesSNP panelGenetic markersMultiple allelesAncestry inferenceNucleotide polymorphismsCodominant systemsTandem repeat polymorphismMicrohaplotypesLociSequencingIndividual identificationRepeat polymorphismPolymorphismField of forensicsDNAHaplotypesReadsPhenotypeAlleles
2013
An historical perspective on “The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus”
Kidd KK, Pakstis AJ, Yun L. An historical perspective on “The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus”. Human Genetics 2013, 133: 431-433. PMID: 24162668, DOI: 10.1007/s00439-013-1386-0.Peer-Reviewed Original ResearchConceptsThousands of lociGene frequency patternsPatterns of divergenceRandom genetic driftHuman population geneticsLow-frequency allelesDopamine D4 receptor locusGenetic driftPopulation geneticsImportant genesPopulation variationWorld-wide distributionReceptor locusFrequency allelesDifferent allelesLociDistinct populationsNative American populationsEast Asian populationsAllelesAllele frequenciesSame populationAmerican populationGenesGenetics
2007
Human genetic variation of medical significance
Kidd K, Kidd J. Human genetic variation of medical significance. 2007, 51-62. DOI: 10.1093/acprof:oso/9780199207466.003.0005.Peer-Reviewed Original ResearchGenetic variationNormal genetic variationRandom genetic driftSignificant genetic variationLoss of variationHuman genetic variationAllele frequency variationHuman evolutionary historyEvolutionary historyGenetic driftNatural selectionModern humansMedical significanceGeographic regionsLociHumansVariationSelectionDemographyMetabolismTaste perceptionComplex waysIsolationMigration
2006
Sub‐Saharan African coding sequence variation and haplotype diversity at the NAT2 gene
Patin E, Harmant C, Kidd K, Kidd J, Froment A, Mehdi S, Sica L, Heyer E, Quintana‐Murci L. Sub‐Saharan African coding sequence variation and haplotype diversity at the NAT2 gene. Human Mutation 2006, 27: 720-720. PMID: 16786516, DOI: 10.1002/humu.9438.Peer-Reviewed Original ResearchConceptsNon-synonymous mutationsNovel non-synonymous mutationsEvolutionary conservationDetailed genetic characterizationIndividuals/populationsHaplotype diversityAgriculturalist populationsSequence variationProtein activityAfrican populationsWestern PygmiesAfrican haplotypesGenetic characterizationUnknown functional effectsGenesFunctional effectsNAT2 geneHaplotype frequenciesSub-Saharan African populationsMutationsChromosomesDamaging effectsLociPopulationProtein
2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
2003
Selective Pressure has not Acted Against Hypercoagulability Alleles in High‐Altitude Amerindians
Rupert J, Monsalve M, Kidd K, Tan C, Hochachka P, Devine D. Selective Pressure has not Acted Against Hypercoagulability Alleles in High‐Altitude Amerindians. Annals Of Human Genetics 2003, 67: 426-432. PMID: 12940916, DOI: 10.1046/j.1469-1809.2003.00043.x.Peer-Reviewed Original Research
2000
Identifying conservation units within captive chimpanzee populations
Deinard A, Kidd K. Identifying conservation units within captive chimpanzee populations. American Journal Of Biological Anthropology 2000, 111: 25-44. PMID: 10618587, DOI: 10.1002/(sici)1096-8644(200001)111:1<25::aid-ajpa3>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsGenetic diversityNuclear lociCaptive management programsGene poolGenetic dataPygmy chimpanzeesWild gene poolDNA sequence dataCommon chimpanzee subspeciesConservation unitsMitochondrial D-loopCaptive managementCaptive populationsChimpanzee populationsCaptive chimpanzee populationEvolutionary relationshipsDiversitySequence dataPolymorphic microsatellitesD-loopChimpanzee subspeciesMicrosatellite allelesManagement programCommon chimpanzeesLoci
1999
Evolution of a HOXB6 intergenic region within the great apes and humans
Deinard A, Kidd K. Evolution of a HOXB6 intergenic region within the great apes and humans. Journal Of Human Evolution 1999, 36: 687-703. PMID: 10330333, DOI: 10.1006/jhev.1999.0298.Peer-Reviewed Original ResearchConceptsCommon ancestorGenetic variationGenetic dataIntraspecific genetic variationHomo-Pan cladeGreat apesNuclear lociGreat ape speciesMolecular evolutionIntraspecific dataPhylogenetic reconstructionIntergenic regionIntraspecific variationDNA sequencesNucleotide substitutionsGenetic polymorphismsHomo-PanPygmy chimpanzeesApe speciesCommon chimpanzeesCladeHomo sapiens sapiensAncestorGorillasLociLinkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism
Osier M, Pakstis A, Kidd J, Lee J, Yin S, Ko H, Edenberg H, Lu R, Kidd K. Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism. American Journal Of Human Genetics 1999, 64: 1147-1157. PMID: 10090900, PMCID: PMC1377839, DOI: 10.1086/302317.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DehydrogenaseAlcoholismAllelesBase SequenceChinaChromosomes, Human, Pair 4Cloning, MolecularGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHaplotypesHumansIndians, Central AmericanLinkage DisequilibriumMexicoMolecular Sequence DataMultigene FamilyNative Hawaiian or Other Pacific IslanderPolymorphism, Single NucleotideRacial GroupsTaiwanConceptsProportion of chromosomesAlcohol dehydrogenase geneDehydrogenase geneChromosome 4Functional variantsChromosomesLinkage disequilibriumADH2Functional polymorphismsADH3Allele frequenciesPairwise disequilibriumGenesIntronic polymorphismDisequilibriumPolymorphismDifferent efficienciesRisk of alcoholismHigher VmaxClass I alcohol dehydrogenase (ADH) genesVariantsLociKbHaplotypesPopulationAllele Frequencies in a Worldwide Survey of a CA Repeat in the First Intron of the CFTR Gene
Mateu E, Calafell F, Bonné-Tamir B, Kidd J, Casals T, Kidd K, Bertranpetit J. Allele Frequencies in a Worldwide Survey of a CA Repeat in the First Intron of the CFTR Gene. Human Heredity 1999, 49: 15-20. PMID: 9858852, DOI: 10.1159/000022834.Peer-Reviewed Original ResearchConceptsCFTR geneIntron 1Allele frequenciesMolecular varianceGenetic varianceFirst intronDinucleotide CACA repeatsGenesCF mutationsHaplotypic analysisMutationsMajor geographical areasAfrican populationsUnknown mutationsAllele distributionPolymorphismCystic fibrosisIntronsChromosomesRepeatsGeographical regionsLociHeterozygosityPopulation
1996
Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR
Michalatos-Beloin S, Tishkoff S, Bentley K, Kidd K, Ruano G. Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR. Nucleic Acids Research 1996, 24: 4841-4843. PMID: 8972876, PMCID: PMC146303, DOI: 10.1093/nar/24.23.4841.Peer-Reviewed Original ResearchConceptsMolecular haplotypingClassical Mendelian analysisMapping disease genesCD4 locusMolecular haplotypesDisease genesLong-range PCRGenomic samplesFounder effectPolymorphic markersMendelian analysisUnrelated individualsHaplotypingAlu deletionKbRange PCRHaplotypesDiversity researchPopulation samplingPCRChromosomesGenesRepeatsLociDeletionMinisatellite diversity supports a recent African origin for modern humans
Armour J, Anttinen T, May C, Vega E, Sajantila A, Kidd J, Kidd K, Bertranpetit J, Pääbo S, Jeffreys A. Minisatellite diversity supports a recent African origin for modern humans. Nature Genetics 1996, 13: 154-160. PMID: 8640220, DOI: 10.1038/ng0696-154.Peer-Reviewed Original ResearchConceptsRecent African originNon-African populationsModern human diversityAllelic diversityMinisatellite diversityVariable lociAncestral relationshipsHuman chromosomesAllelic structureAfrican originGreat diversityDiversityHuman diversityAfrican chromosomesChromosomesAllele familiesLociModern humansDifferent populationsDRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research
Kidd K, Pakstis A, Castiglione C, Kidd J, Speed W, Goldman D, Knowler W, Lu R, Bonne‐Tamir B. DRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research. Alcohol Clinical And Experimental Research 1996, 20: 697-705. PMID: 8800387, DOI: 10.1111/j.1530-0277.1996.tb01674.x.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAllelesAnimalsChromosome MappingDeoxyribonucleases, Type II Site-SpecificEthnicityGene FrequencyGenetics, PopulationHaplotypesHumansPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Repetitive Sequences, Nucleic AcidResearchConceptsGenetic variationAssociation studiesUnrelated control samplesDopamine D2 receptor locusDiversity of haplotypesShort tandem repeat polymorphismsDRD2 locusEvolutionary historyRestriction fragment length polymorphismPopulation geneticsPhylogenetic originFragment length polymorphismAncestral originReceptor locusHomologous regionsIntron 2LociAllelic systemHigher primatesHaplotypesTandem repeat polymorphismAllelesConsiderable diversityDRD2 haplotypesPolymorphismDistribution and frequency of a polymorphicAlu insertion at the plasminogen activator locus in humans
Tishkoff S, Ruano G, Kidd J, Kidd K. Distribution and frequency of a polymorphicAlu insertion at the plasminogen activator locus in humans. Human Genetics 1996, 97: 759-764. PMID: 8641693, DOI: 10.1007/bf02346186.Peer-Reviewed Original ResearchConceptsPlasminogen activator geneHuman populationTissue plasminogen activator geneRestriction fragment length polymorphismActivator geneActivator locusInsertion eventsFragment length polymorphismPLAT locusHuman evolutionPolymerase chain reaction analysisChain reaction analysisLength polymorphismPresence/absenceAllele frequenciesAllelesLociModern humans