2015
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor
Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood 2015, 125: 3377-3387. PMID: 25814526, PMCID: PMC4447857, DOI: 10.1182/blood-2015-01-620278.Peer-Reviewed Original ResearchConceptsVon Willebrand factorDiabetes mellitusMiR-24Diabetic patientsAdverse thrombotic eventsThrombotic cardiovascular eventsVWF expressionWillebrand factorDiabetic mouse modelNovel therapeutic targetHistamine H1 receptorsEndothelial cell expressionHyperglycemia-induced activationCardiovascular eventsThrombotic eventsH1 receptorsMouse modelVWF levelsTherapeutic targetCell expressionMellitusPatientsEndothelial cellsElevated levelsReactive oxygen species
2007
Altered microRNA expression in human heart disease
Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT. Altered microRNA expression in human heart disease. Physiological Genomics 2007, 31: 367-373. PMID: 17712037, DOI: 10.1152/physiolgenomics.00144.2007.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceCase-Control StudiesFemaleHeart DiseasesHumansMaleMicroRNAsMiddle AgedConceptsHeart diseaseDiagnostic groupsHuman heart failureLeft ventricular samplesHeart disease pathogenesisHeart failureIschemic cardiomyopathyDisease groupHeart functionDisease pathogenesisExpression profilesControl groupHuman heart diseaseVentricular samplesClinical diagnosisHuman left ventricular samplesContribution of microRNAsDiseaseFurther studiesImportant regulatorMultiple testingMiRNA expressionMicroRNAsExpressionGroup