Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency
Korol C, Belkaya S, Alsohime F, Lorenzo L, Boisson-Dupuis S, Brancale J, Neehus A, Vilarinho S, Zobaida A, Halwani R, Al-Muhsen S, Casanova J, Jouanguy E. Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency. Journal Of Clinical Immunology 2022, 43: 406-420. PMID: 36308662, PMCID: PMC9892130, DOI: 10.1007/s10875-022-01376-5.Peer-Reviewed Original ResearchConceptsEarly onset inflammatory bowel diseaseFulminant viral hepatitisHepatitis A virusIL-10IL-22IL-26Viral hepatitisIFN-λ1Inflammatory bowel diseaseIFN-γ productionIFN-γ activityLife-threatening diseaseImpairs cellular responsesHAV infectionBowel diseaseLymphocyte cytotoxicityIL-18BPIFN-λsDisease-causing variantsHealthy individualsPatientsA virusCellular responsesUnrelated patientsPotent antagonist