2016
DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders
Wang F, Xu H, Zhao H, Gelernter J, Zhang H. DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Scientific Reports 2016, 6: 19430. PMID: 26763658, PMCID: PMC4725922, DOI: 10.1038/srep19430.Peer-Reviewed Original ResearchConceptsCo-methylation modulesPostmortem prefrontal cortex tissueDNA methylome alterationsCo-methylation analysisDNA methylation alterationsSubstance dependence phenotypesTranscriptional regulationDNA methylomeMethylation alterationsMethylome alterationsBiological processesPostmortem prefrontal cortexExpression relationshipsNeural developmentDifferential expressionPrefrontal cortex tissueGenesDependence phenotypesMultiple testing correctionCpGAUD subjectsFemale pairsCortex tissueMethylomePhenotype
2011
Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases
Li D, Zhao H, Gelernter J. Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases. Biological Psychiatry 2011, 70: 504-512. PMID: 21497796, PMCID: PMC3142297, DOI: 10.1016/j.biopsych.2011.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DehydrogenaseAlcohol-Induced DisordersAlcoholismEthnicityGenetic Association StudiesGenetic Predisposition to DiseaseHumansConceptsAlcohol dependenceAlcohol dehydrogenase 1B (ADH1B) geneMedical diseasesAlcohol-induced liver diseaseStrong associationCertain Asian populationsRandom-effects modelADH1B geneLarger ORsLiver diseaseSubgroup analysisLarger sample sizeDrug dependenceSignificant associationSubstance dependenceMultiple ethnic populationsRecessive modelAsian populationsDisease