2018
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population
Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. Alcohol Clinical And Experimental Research 2018, 42: 861-868. PMID: 29460428, PMCID: PMC5916336, DOI: 10.1111/acer.13614.Peer-Reviewed Original ResearchConceptsGenomewide association studiesAssociation studiesRisk genesAldehyde dehydrogenase 2Prior biological informationAfrican ancestry populationsRelated traitsSame geneBiological informationAlcohol dehydrogenasesSignificant pleiotropyDehydrogenase BGenesFunctional variantsPsychiatric traitsGenomewide significant associationPleiotropy analysisTraitsAncestry populationsFirst genomewide association studyPleiotropyDehydrogenase 2Null variants
2017
Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center
Rungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. Journal Of Addiction Medicine 2017, 11: 19. PMID: 27649265, PMCID: PMC5291761, DOI: 10.1097/adm.0000000000000262.Peer-Reviewed Original ResearchConceptsMA dependenceMA useLifetime episodesTreatment centersLogistic regression analysisResidential drug treatmentChi-square testSex differencesSemi-Structured AssessmentAntisocial personality disorderMA diagnosisMA withdrawalTreatment cohortsComorbid antisocial personality disorderAssociated FactorsDrug treatmentSex-specific differencesNicotine dependencePsychomotor retardationDrug dependenceLogistic regressionMethamphetamine useMA usersPersonality disorderMethamphetamine
2015
Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets
Vongpaisarnsin K, Listman JB, Malison RT, Gelernter J. Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets. Legal Medicine 2015, 17: 245-250. PMID: 25759192, PMCID: PMC4480199, DOI: 10.1016/j.legalmed.2015.02.004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAncestry informative markersAssociation studiesGenome-wide association datasetInformative markersGenetic structureHapMap populationsSNP dataInternational HapMap databaseSuch SNPsEast Asian populationsHapMap databaseSNPsMarkersPopulationDiversityAsian populationsEfficient strategyThai population
2014
Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort
Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort. Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.Peer-Reviewed Original ResearchConceptsDopamine β-hydroxylaseMethamphetamine-dependent individualsAssociated clinical variablesGenetic polymorphismsΒ-hydroxylaseLogistic regression analysisSubstance abuse treatment centersHigh-activity genotypesSemi-Structured AssessmentAntisocial personality disorderCT carriersCent of individualsClinical featuresClinical presentationCigarette smokingClinical variablesRetrospective analysisTreatment centersDrug dependenceActivity genotypeMethamphetamine useMethamphetamine dependencePersonality disorderRegression analysisGenetic association
2011
Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, Gueorguieva R, Kranzler HR, Gelernter J. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addictive Behaviors 2011, 36: 156-160. PMID: 20888699, PMCID: PMC2981662, DOI: 10.1016/j.addbeh.2010.08.031.Peer-Reviewed Original Research
2007
Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J. Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. Genomics 2007, 91: 61-69. PMID: 17976953, PMCID: PMC2709929, DOI: 10.1016/j.ygeno.2007.08.007.Peer-Reviewed Original ResearchConceptsLinkage disequilibrium patternsDisequilibrium patternsHuman chromosome 4Intergenic distancesIntergenic regionHaplotype block structureChromosome 4Haplotype structureLD blocksFunctional variantsGamma 1 subunitChromosome 4pHigh LDGABRA2 locusGenetic associationGenesLociDifferent populationsAlpha 2GABRA2KbSubunitsPopulationReported associationsGABRG1Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
Hirunsatit R, Ilomäki R, Malison R, Räsänen P, Ilomäki E, Kranzler HR, Kosten T, Sughondhabirom A, Thavichachart N, Tangwongchai S, Listman J, Mutirangura A, Gelernter J, Lappalainen J. Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research. BMC Genomic Data 2007, 8: 71. PMID: 17941974, PMCID: PMC2175509, DOI: 10.1186/1471-2156-8-71.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAsian PeopleBlack or African AmericanFinlandGABA Plasma Membrane Transport ProteinsGenetic Predisposition to DiseaseGenetic VariationHaplotypesHumansLinkage DisequilibriumPharmacogeneticsPolymorphism, Single NucleotidePromoter Regions, GeneticRecombination, GeneticSequence Analysis, DNAThailandWhite PeopleConceptsLinkage disequilibriumGenetic diversityVariable number tandem repeatHigh genetic diversityPopulation-specific variantsTransporter 1 geneProblematic genesRecombination hotspotsGenetic variationSequence variationContinental groupsIntronic regionsGenetic studiesLD blocksTandem repeatsNumber tandem repeatGAT-1 functionCandidate allelesLD patternsPopulation differencesNovel targetTag SNPsSuch variantsGenesTransporter 1Demographic changes and marker properties affect detection of human population differentiation
Listman JB, Malison RT, Sughondhabirom A, Yang BZ, Raaum RL, Thavichachart N, Sanichwankul K, Kranzler HR, Tangwonchai S, Mutirangura A, Disotell TR, Gelernter J. Demographic changes and marker properties affect detection of human population differentiation. BMC Genomic Data 2007, 8: 21. PMID: 17498298, PMCID: PMC1876243, DOI: 10.1186/1471-2156-8-21.Peer-Reviewed Original Research