POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING
Nievergelt C, Ongeri L, Gelernter J. POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING. European Neuropsychopharmacology 2024, 87: 2-3. DOI: 10.1016/j.euroneuro.2024.08.013.Peer-Reviewed Original ResearchPosttraumatic stress disorderPGC-PTSDLocal ancestry inferencePTSD associationsRisk lociPosttraumatic stress disorder casenessThreat-related processingGenome-wide association study resultsCo-morbid disordersComplex patterns of admixtureStress-related disordersMental health disordersPatterns of admixturePotential causal genesMajor histocompatibility complexMental health consequencesAssociation study resultsMDD patientsMulti-omics approachStress disorderMulti-omics studiesHuman leukocyte antigenAncestry inferenceAdmixed individualsMDDEXPLORING THE IMMUNOGENETIC BASIS OF POST-TRAUMATIC STRESS DISORDER
Braun A, Maihofer A, Katrinli S, Panagiotaropoulou G, Levey D, Ripke S, Gelernter J, Nievergelt C, Group P. EXPLORING THE IMMUNOGENETIC BASIS OF POST-TRAUMATIC STRESS DISORDER. European Neuropsychopharmacology 2024, 87: 4-5. DOI: 10.1016/j.euroneuro.2024.08.017.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation analysisPost-traumatic stress disorderMajor histocompatibility complexHuman leukocyte antigen imputationComplex linkage disequilibrium structureGenomes reference panelLinkage disequilibrium structureMajor histocompatibility complex class III regionRisk-conferring allelesClass III regionPsychiatric Genomics ConsortiumHuman leukocyte antigen allelesMillion Veteran ProgramDisequilibrium structureLatin American ancestryRisk lociRisk-conferring variantsCross-ancestryAssociation studiesPopulation stratificationReference panelGenetic variantsSusceptibility to post-traumatic stress disorderAmerican ancestry