2019
Differentiating Types of Self-Reported Alcohol Abstinence
Gordon KS, McGinnis K, Dao C, Rentsch CT, Small A, Smith RV, Kember RL, Gelernter J, Kranzler HR, Bryant KJ, Tate JP, Justice AC. Differentiating Types of Self-Reported Alcohol Abstinence. AIDS And Behavior 2019, 24: 655-665. PMID: 31435887, PMCID: PMC6994373, DOI: 10.1007/s10461-019-02638-x.Peer-Reviewed Original ResearchConceptsLifetime abstainersSelf-reported alcohol abstinenceAlcohol biomarkersGenetic polymorphismsLogistic regression modelsHepatitis CAlcohol abstinenceUninfected individualsCharacteristics of peopleAlcohol useAbstinenceHealth effectsSmokingAbstainersBiomarkersRegression modelsOddsAssociationPLWHPolymorphismHIVCocaine
2017
Genomewide association studies of suicide attempts in US soldiers
Stein MB, Ware EB, Mitchell C, Chen C, Borja S, Cai T, Dempsey CL, Fullerton CS, Gelernter J, Heeringa SG, Jain S, Kessler RC, Naifeh JA, Nock MK, Ripke S, Sun X, Beckham JC, Kimbrel NA, VA Mid‐Atlantic Mental Illness Research E, Ursano RJ, Smoller JW. Genomewide association studies of suicide attempts in US soldiers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 786-797. PMID: 28902444, PMCID: PMC5685938, DOI: 10.1002/ajmg.b.32594.Peer-Reviewed Original ResearchConceptsSuicide attemptsPlausible susceptibility geneGlobal public health problemPeak SNPPolygenic risk score analysisPublic health problemGenomewide association studiesSignificant SNPsSignificant lociGenetic risk factorsLogistic regression modelsUS military personnelAncestral groupsAssociation studiesGenomewide associationRecent suicide attemptersSusceptibility genesRisk factorsAdrenal cortexCase-control sampleRisk score analysisAncestral subgroupsLarger sample sizeBipolar disorderHealth problems
2016
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016, 73: 695-704. PMID: 27167565, PMCID: PMC4936936, DOI: 10.1001/jamapsychiatry.2016.0350.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsCase-Control StudiesChromosomes, Human, Pair 19Chromosomes, Human, Pair 5Cohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMilitary PersonnelPolymorphism, Single NucleotideStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderTrauma-exposed controlsNew Soldier StudyRheumatoid arthritisStress disorderLifetime posttraumatic stress disorderSerious public health concernUnique participantsImmune-related disordersCumulative trauma exposureGenetic risk factorsPublic health concernLogistic regression modelsUS Army soldiersGenome-wide association studiesInflammatory disordersLifetime riskRisk factorsMAIN OUTCOMEPrimary analysisPost Deployment StudyAssociation studiesControl individualsMental disordersSignificant association
2013
Rate of progression from first use to dependence on cocaine or opioids: A cross-substance examination of associated demographic, psychiatric, and childhood risk factors
Sartor CE, Kranzler HR, Gelernter J. Rate of progression from first use to dependence on cocaine or opioids: A cross-substance examination of associated demographic, psychiatric, and childhood risk factors. Addictive Behaviors 2013, 39: 473-479. PMID: 24238782, PMCID: PMC3855905, DOI: 10.1016/j.addbeh.2013.10.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAlcohol-Related DisordersBehavior, AddictiveCase-Control StudiesChildChild AbuseCluster AnalysisCocaine-Related DisordersConnecticutCross-Sectional StudiesDiagnosis, Dual (Psychiatry)Disease ProgressionFemaleHumansInterviews as TopicLogistic ModelsMaleMental DisordersMiddle AgedOpioid-Related DisordersPennsylvaniaRisk FactorsSocial EnvironmentSocioeconomic FactorsSouth CarolinaTime FactorsConceptsChildhood risk factorsOpioid dependenceOpioid-dependent participantsRisk factorsCocaine dependenceDependent participantsImportant public health goalRate of progressionPublic health goalsLogistic regression modelsBlack/African AmericanChildhood physical abuseOrdinal logistic regression modelsCocaine-dependent participantsMean ageSlow progressionElevated riskAssociated demographicPsychiatric disordersMulti-site studyDependence diagnosisGreater riskHealth goalsSubstance dependenceConduct disorder
2006
Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease
Zdanys KF, Kleiman TG, MacAvoy MG, Black BT, Rightmer TE, Grey M, Garman KS, Tampi RR, Gelernter J, van Dyck CH. Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease. Neuropsychopharmacology 2006, 32: 171-179. PMID: 16841077, DOI: 10.1038/sj.npp.1301148.Peer-Reviewed Original ResearchConceptsAD patientsPsychotic symptomsAlzheimer's diseaseBehavioral symptomsNeuropsychiatric InventoryApolipoprotein EMultiple logistic regression modelSporadic Alzheimer's diseaseGenetic risk factorsSevere-stage Alzheimer's diseaseLogistic regression modelsDifferent risk profilesDementia progressesRisk factorsIncrease riskBehavioral disturbancesPatientsDisease severitySymptomsSignificant psychosisRisk profileGreater riskApoEExploratory analysisDisease