2014
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersCocaine-induced paranoiaAnxiety disorder casesWhole blood cellsPsychiatric disorder riskWarrants further investigationAfrican American subjectsComorbid drugPD casesPsychiatric disordersAlcohol dependenceBrain tissueCocaine useBehavioral effectsBlood cellsClinical potentialGene variantsDisordersDisorder casesSingle nucleotide polymorphismsDisorder riskIndependent samplesPsychiatric phenotypesFurther investigation
2013
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry 2013, 19: 717-723. PMID: 23958962, PMCID: PMC3865158, DOI: 10.1038/mp.2013.99.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCDC2 Protein KinaseCocaineCocaine-Related DisordersCyclin-Dependent KinasesDopamine Uptake InhibitorsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotyping TechniquesHumansMaleNuclear Receptor Co-Repressor 2Paranoid DisordersPolymorphism, Single NucleotideUnited StatesWhite PeopleConceptsGenome-wide association studiesAssociation studiesAvailable GWAS dataSignificant GWAS SNPsNovel risk lociGWAS data setsSame chromosomal regionDiscovery sampleGenomes reference panelPrevious linkage studiesGWAS SNPsGWAS dataRelated traitsChromosomal regionsRisk lociRisk genesRisk variantsGenesReference panelAdditional genotypesLinkage studiesLociEuropean-American subjectsCocaine-induced paranoiaFAM53B
2011
Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populations
Ittiwut R, Listman JB, Ittiwut C, Cubells JF, Weiss RD, Brady K, Oslin D, Farrer LA, Kranzler HR, Gelernter J. Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 651-660. PMID: 21656904, PMCID: PMC3864552, DOI: 10.1002/ajmg.b.31205.Peer-Reviewed Original Research
2009
Adolescent cannabis use increases risk for cocaine-induced paranoia
Kalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT. Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug And Alcohol Dependence 2009, 107: 196-201. PMID: 19944543, PMCID: PMC2821949, DOI: 10.1016/j.drugalcdep.2009.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAge FactorsAge of OnsetCannabisCatechol O-MethyltransferaseCocaine-Related DisordersFemaleGene FrequencyGenetic Predisposition to DiseaseHumansLogistic ModelsMaleParanoid DisordersPolymerase Chain ReactionPrevalencePsychiatric Status Rating ScalesRisk FactorsSeverity of Illness IndexSiblingsUnited StatesConceptsAdolescent onset cannabisEarly cannabis exposureCocaine-dependent individualsCocaine-induced paranoiaCannabis exposureRisk factorsCOMT genotypeSemi-Structured AssessmentCatechol-O-methyl transferase (COMT) geneCOMT Val158Met genotypeCannabis abuseIncrease riskPsychotic symptomsOnset interactionPsychotic disordersStimulant abuseDrug dependenceFamily-based studyLogistic regressionEarly exposureAdolescent cannabisCannabisGenetic factorsSignificant predictorsVal158Met genotype
2008
Substance dependence low-density whole genome association study in two distinct American populations
Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA, Gelernter J. Substance dependence low-density whole genome association study in two distinct American populations. Human Genetics 2008, 123: 495. PMID: 18438686, PMCID: PMC3428017, DOI: 10.1007/s00439-008-0501-0.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphism (SNP) markersWhole-genome association studiesFuture candidate gene studiesGenome association studiesCandidate gene studiesPotential biological relevancePolymorphism markersGenetic basisAssociation studiesGenetic markersHigh heritabilityGene studiesCocaine-induced paranoiaBiological relevanceGenesComplex disorderNew hypothesisFamilyAmerican populationGeneticsHeritabilityMarkers
2006
Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
Malison RT, Kranzler HR, Yang BZ, Gelernter J. Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. Psychiatric Genetics 2006, 16: 245-249. PMID: 17106427, DOI: 10.1097/01.ypg.0000242198.59020.ca.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsNucleotide polymorphismsCircadian rhythm genesDrosophila melanogasterHuman orthologGenetic variationCocaine-induced paranoiaGenetic mechanismsRhythm genesGene single nucleotide polymorphismsPopulation comparisonsHuman clockLack of associationPotential involvementAllelic associationClinical featuresAllele frequenciesStimulant exposureBehavioral sensitizationLocomotor sensitizationPsychostimulant addictionDrug useClinical phenotypeCocaine dependencePER2 polymorphisms
2005
Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
Cubells JF, Feinn R, Pearson D, Burda J, Tang Y, Farrer LA, Gelernter J, Kranzler HR. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Drug And Alcohol Dependence 2005, 80: 23-33. PMID: 15894433, DOI: 10.1016/j.drugalcdep.2005.03.019.Peer-Reviewed Original Research
2002
Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study
Yamamoto K, Cubells JF, Gelernter J, Benkelfat C, Lalonde P, Bloom D, Lal S, Labelle A, Turecki G, Rouleau GA, Joober R. Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2002, 117B: 33-38. PMID: 12555232, DOI: 10.1002/ajmg.b.10011.Peer-Reviewed Original ResearchConceptsTherapeutic responseDopamine beta-hydroxylase (DBH) geneMean total BPRS scoreBeta-hydroxylase geneGroup of patientsTotal BPRS scoreLow DBH activityNR patientsBPRS scoresNeuroleptic drugsHealthy volunteersPsychotic symptomsSchizophrenic patientsDBH activitySymptom profilesPositive linkage disequilibriumPatientsCocaine-induced paranoiaCausative factorsPhenotypic variabilitySchizophreniaGenetic association studiesGenotype differencesPolymorphismDBH gene
2001
The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans
Martinez D, Gelernter J, Abi-Dargham A, van Dyck C, Kegeles L, Innis R, Laruelle M. The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans. Neuropsychopharmacology 2001, 24: 553-560. PMID: 11282255, DOI: 10.1016/s0893-133x(00)00216-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphetamineAttention Deficit Disorder with HyperactivityBenzamidesCarrier ProteinsCocaineCocaine-Related DisordersDopamineDopamine AntagonistsDopamine Plasma Membrane Transport ProteinsGenotypeHumansIodine RadioisotopesMembrane GlycoproteinsMembrane Transport ProteinsMinisatellite RepeatsNeostriatumNerve Tissue ProteinsPhenotypePolymorphism, GeneticPsychotic DisordersPyrrolidinesRadiopharmaceuticalsSchizophreniaTomography, Emission-Computed, Single-PhotonConceptsAmphetamine-induced dopamine releaseDopamine releaseDAT expressionDopamine transporterDifferent patient populationsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeurochemical phenotypePatient populationHealthy controlsDAT densityComputerized emission tomographyDopamine transmissionClinical phenotypeDiagnostic groupsSignificant associationEmission tomographyCocaine-induced paranoiaHyperactivity disorderTandem repeat polymorphismVNTR polymorphismDopamine transporter geneRepeat polymorphismTotal sample
1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein gene