2023
Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders
Li W, Zhou H, Thygesen J, Heydtmann M, Smith I, Degenhardt F, Nöthen M, Morgan M, Kranzler H, Gelernter J, Bass N, McQuillin A. Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders. Psychiatric Genetics 2023, 33: 233-242. PMID: 37756443, PMCID: PMC10635348, DOI: 10.1097/ypg.0000000000000352.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderAttention deficit hyperactivity disorderSubstance use disordersPosttraumatic stress disorderGenome-wide association studiesDeficit hyperactivity disorderDisorder diagnostic criteriaRisk factorsFrontal cortexDiagnostic criteriaUse disordersRisk score analysisAnterior cingulateAlcohol-dependent participantsPsychiatric conditionsSignificant associationBrain regionsPersonality disorder diagnostic criteriaStress disorderAnxiety disordersASPD criteriaHyperactivity disorderPolygenic risk score analysisPersonality disorderScore analysisPolysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Stiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.Peer-Reviewed Original ResearchCocaine use disorderUse disordersAddiction patternsMixed bipolar episodesLatent class analysisDSM-5 diagnosisPosttraumatic stress disorderAntisocial personality disorderPsA severityMedication useHigher PSAPSA subgroupsHigher oddsBipolar episodesStress disorderPersonality disorderDisordersSubgroupsAgeSexClass analysisParticipantsComorbiditiesDiseaseDiagnosis
2022
Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use
Rattanasumawong W, Malison R, Gelernter J, Nunez Y, Kalayasiri R. Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use. The International Journal Of Alcohol And Drug Research 2022, 9: 77-84. DOI: 10.7895/ijadr.345.Peer-Reviewed Original ResearchAntisocial personality disorderBaseline socio-demographic informationMA useCross-sectional baseline dataPersonality disorderSevere clinical presentationMethamphetamine usersSocio-demographic informationGreater subsequent useSemi-Structured AssessmentCohort studyClinical presentationAdult methamphetamine usersFamily historyChildhood exposureDrug useRespective drugsAlcohol dependenceDrug dependenceDrug typeAlcohol useFamily exposureMA usersBaseline dataSelf-harm experience
2017
Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center
Rungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. Journal Of Addiction Medicine 2017, 11: 19. PMID: 27649265, PMCID: PMC5291761, DOI: 10.1097/adm.0000000000000262.Peer-Reviewed Original ResearchConceptsMA dependenceMA useLifetime episodesTreatment centersLogistic regression analysisResidential drug treatmentChi-square testSex differencesSemi-Structured AssessmentAntisocial personality disorderMA diagnosisMA withdrawalTreatment cohortsComorbid antisocial personality disorderAssociated FactorsDrug treatmentSex-specific differencesNicotine dependencePsychomotor retardationDrug dependenceLogistic regressionMethamphetamine useMA usersPersonality disorderMethamphetamine
2014
Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort
Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort. Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.Peer-Reviewed Original ResearchConceptsDopamine β-hydroxylaseMethamphetamine-dependent individualsAssociated clinical variablesGenetic polymorphismsΒ-hydroxylaseLogistic regression analysisSubstance abuse treatment centersHigh-activity genotypesSemi-Structured AssessmentAntisocial personality disorderCT carriersCent of individualsClinical featuresClinical presentationCigarette smokingClinical variablesRetrospective analysisTreatment centersDrug dependenceActivity genotypeMethamphetamine useMethamphetamine dependencePersonality disorderRegression analysisGenetic association
2011
5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder
Douglas K, Chan G, Gelernter J, Arias AJ, Anton RF, Poling J, Farrer L, Kranzler HR. 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder. Psychiatric Genetics 2011, 21: 240-248. PMID: 21399568, PMCID: PMC3119731, DOI: 10.1097/ypg.0b013e3283457c15.Peer-Reviewed Original ResearchConceptsAdverse childhood eventsAntisocial personality disorderSubstance dependenceRisk factorsAA womenPersonality disorder
2008
Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals
Ford JD, Gelernter J, DeVoe JS, Zhang W, Weiss RD, Brady K, Farrer L, Kranzler HR. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug And Alcohol Dependence 2008, 99: 193-203. PMID: 18775607, PMCID: PMC2745327, DOI: 10.1016/j.drugalcdep.2008.07.004.Peer-Reviewed Original ResearchConceptsCocaine dependence severitySubstance use disordersTreatment utilizationSelf-help group participationDependence severityPsychiatric disordersUse disordersCo-occurring substance dependenceMajor depressive disorderSubstance dependence disordersAssociation of psychiatricLogistic regression analysisCocaine dependence treatmentPosttraumatic stress disorderSemi-Structured AssessmentAntisocial personality disorderHeavy cocaine useClinical managementDependence treatmentDepressive disorderDisorder comorbidityService utilizationCocaine-dependent individualsDependence disordersBipolar disorder
2007
Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects
Tang Y, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects. American Journal On Addictions 2007, 16: 343-351. PMID: 17882604, DOI: 10.1080/10550490701525723.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCocaine-Induced PsychosisComorbid substance useAntisocial personality disorderCocaine Experience QuestionnairePsychiatric disordersUse disordersPsychiatric diagnosisCocaine dependenceAxis I psychiatric diagnosesComorbid opioid dependenceSubstance useAdult antisocial personality disorderComorbid attention deficit hyperactivity disorderPercent of subjectsComorbid psychiatric diagnosesDSM-IV diagnosisSubstance use disordersCocaine-dependent adultsCocaine-dependent subjectsCocaine-dependent sampleSemi-Structured AssessmentDrugs of abuseDeficit hyperactivity disorderSuch comorbidities
2004
Typologies of drug dependence: comparative validity of a multivariate and four univariate models
Basu D, Ball SA, Feinn R, Gelernter J, Kranzler HR. Typologies of drug dependence: comparative validity of a multivariate and four univariate models. Drug And Alcohol Dependence 2004, 73: 289-300. PMID: 15036551, DOI: 10.1016/j.drugalcdep.2003.11.004.Peer-Reviewed Original ResearchConceptsDrug dependenceDrug abuse/dependenceLongitudinal cohort studyFirst-degree relativesAbuse/dependencePsychiatric Symptom IndexPredictive validityAntisocial personality disorderGreater concurrent validityCohort studyStrength of associationSymptom IndexAlcohol dependenceB typologyDrug abuseSubstance usePersonality disorderComposite scoreConcurrent validityDegree of changeOverall functioningComparative validitySuperior validityPsychopathologyUnivariate models
2001
Polymorphism of the 5-HT1B Receptor Gene (HTR1B): Strong Within-Locus Linkage Disequilibrium without Association to Antisocial Substance Dependence
Kranzler HR, Hernandez-Avila CA, Gelernter J. Polymorphism of the 5-HT1B Receptor Gene (HTR1B): Strong Within-Locus Linkage Disequilibrium without Association to Antisocial Substance Dependence. Neuropsychopharmacology 2001, 26: 115-122. PMID: 11751038, DOI: 10.1016/s0893-133x(01)00283-4.Peer-Reviewed Original ResearchConceptsSubstance dependenceAlcohol dependenceAntisocial personality disorderAntisocial alcoholismG861C polymorphismAntisocial diagnosisSouthwestern American IndiansAfrican AmericansAllelic associationSerotonergic abnormalitiesSerotonin receptorsFurther evaluationPersonality disorderLinkage disequilibriumReceptor geneDisordersPopulation groupsEuropean AmericansAssociationHTR1BDiagnosisAlcoholismPresent studyAmerican IndiansFunctional variants