2020
A CRISPR Competition Assay to Identify Cancer Genetic Dependencies.
Girish V, Sheltzer JM. A CRISPR Competition Assay to Identify Cancer Genetic Dependencies. Bio-protocol 2020, 10: e3682. PMID: 33659353, PMCID: PMC7842800, DOI: 10.21769/bioprotoc.3682.Peer-Reviewed Original ResearchGenetic dependenciesTargeted locusCancer cell fitnessCRISPR/Cas9 systemGene of interestWhole-genome screenAnti-cancer drug developmentCell fitnessNuclease Cas9Mammalian cellsGenome editingGene dependenciesCas9 systemSpecific genesConsequences of lossCompetition assaysCell linesPotential targetGenesLociCancer typesDrug developmentFunction perturbationsCas9CRISPRDiscovering and validating cancer genetic dependencies: approaches and pitfalls
Lin A, Sheltzer JM. Discovering and validating cancer genetic dependencies: approaches and pitfalls. Nature Reviews Genetics 2020, 21: 671-682. PMID: 32561862, DOI: 10.1038/s41576-020-0247-7.Peer-Reviewed Original Research
2012
Transcriptional consequences of aneuploidy
Sheltzer J, Torres E, Dunham M, Amon A. Transcriptional consequences of aneuploidy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 12644-12649. PMID: 22802626, PMCID: PMC3411958, DOI: 10.1073/pnas.1209227109.Peer-Reviewed Original ResearchConceptsConsequences of aneuploidyRelated gene expression patternsAneuploid cellsSimilar cellular pathwaysGene expression patternsGene expression dataDiverse organismsDifferent organismsTranscriptional consequencesDifferent chromosomesCell physiologyCellular pathwaysExpression patternsGene expressionCell cycleExpression dataDifferent aneuploidiesAntiproliferative responseCell proliferationGenesOrganismsSpeciesAneuploidySpecific chromosomal aberrationsChromosomal aberrations