2013
Investigation of Rett syndrome using pluripotent stem cells
Dajani R, Koo S, Sullivan GJ, Park I. Investigation of Rett syndrome using pluripotent stem cells. Journal Of Cellular Biochemistry 2013, 114: 2446-2453. PMID: 23744605, PMCID: PMC3773984, DOI: 10.1002/jcb.24597.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsStem cellsRett syndromeFunction of MeCP2Pathophysiology of RTTEmbryonic stem cellsEpigenetic instabilityTranscription factorsDe novo mutationsRTT phenotypeCurrent iPSCHuman diseasesMeCP2Novo mutationsIPSCsCellsNeurodevelopmental disordersOverexpressionMutationsPhenotypeMurine modelRecapitulationMaintenanceIdentification
2012
Cellular reprogramming: a novel tool for investigating autism spectrum disorders
Kim KY, Jung YW, Sullivan GJ, Chung L, Park IH. Cellular reprogramming: a novel tool for investigating autism spectrum disorders. Trends In Molecular Medicine 2012, 18: 463-471. PMID: 22771169, PMCID: PMC3785941, DOI: 10.1016/j.molmed.2012.06.002.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsNovel ASD genesUse of iPSCsHuman disease modelsPluripotent stem cellsSomatic cellsGenomic technologiesAdvanced geneticsASD genesCellular modelStem cellsScreening platformSmall moleculesDisease modelsNovel toolNeurodevelopmental disordersUnprecedented opportunityCellsGenesGeneticsCell therapyAutism spectrum disorderMurine modelFuture perspectivesReciprocal social interactionHumanized murine model for HBV and HCV using human induced pluripotent stem cells
Zhou XL, Sullivan GJ, Sun P, Park IH. Humanized murine model for HBV and HCV using human induced pluripotent stem cells. Archives Of Pharmacal Research 2012, 35: 261-269. PMID: 22370780, PMCID: PMC3731984, DOI: 10.1007/s12272-012-0206-8.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusMouse modelHepatocellular carcinomaHuman hepatocytesPathogenesis of HBVVivo transgenic mouse modelAcute asymptomatic infectionsStem cellsHumanized murine modelHumanized mouse modelHuman HCC cell linesNovel mouse modelTransgenic mouse modelPluripotent stem cellsHCC cell linesHuman primary hepatocytesPrimary human hepatocytesAsymptomatic infectionC virusChronic infectionB virusSusceptibility of hepatocytesImmunodeficient miceMurine model