2020
Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model
Noh JE, Oh SH, Park IH, Song J. Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model. Frontiers In Cellular Neuroscience 2020, 14: 546659. PMID: 33100972, PMCID: PMC7546889, DOI: 10.3389/fncel.2020.546659.Peer-Reviewed Original ResearchHuman umbilical cord-derived mesenchymal stromal cellsMiddle cerebral artery occlusionMesenchymal stromal cellsSubacute phaseRodent modelsUmbilical cord-derived mesenchymal stromal cellsStromal cellsIschemic penumbra regionCerebral artery occlusionGlial scar formationDelivery modeSame time pointsHuman umbilical cordStem cell therapyCandidate cell typesInfarct volumeArtery occlusionIschemic strokeIntracerebral transplantsTransplanted ratsCell-based therapiesChronic phaseFunctional recoveryTherapeutic effectBehavioral deficits
2008
Patient-Specific Induced Pluripotent Stem Cells in Hurler Syndrome
Tolar J, Park I, Xia L, Osborn M, McElmurry R, Orchard P, Daley G, Blazar B. Patient-Specific Induced Pluripotent Stem Cells in Hurler Syndrome. Blood 2008, 112: 386. DOI: 10.1182/blood.v112.11.386.386.Peer-Reviewed Original ResearchGreen fluorescent proteinPluripotent stem cellsIPS cellsStem cellsMesenchymal stromal cellsTumor rejection antigen-1Such induced pluripotent stem cellsWild-type levelsAutologous pluripotent cellsTransient mRNA expressionInduced pluripotent stem cellsMouse embryo fibroblastsStage-specific embryonic antigen-3Adult stem cellsEmbryonic stem cell isolationHematopoietic progenyHematopoietic stem cellsStable transgenesisTransposon insertionMesodermal lineagesNumerous tissue typesSleeping Beauty transposon systemTranscription factorsNon-viral Sleeping Beauty (SB) transposon systemPluripotent cells