2010
Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms. Journal Of Virology 2010, 85: 43-50. PMID: 20962093, PMCID: PMC3014194, DOI: 10.1128/jvi.01774-10.Peer-Reviewed Original ResearchConceptsNK cellsHIV/AIDSAnti-HIV-1 immunityHIV-1-infected individualsAntibody-dependent cellular cytotoxicityTumor cellsCEM-GFP cellsFunctional NK cellsAnti-HIV-1 activityNatural killer cellsHIV-1 infectionProduction of chemokinesCellular mechanismsHIV-1 replicationStem cellsCellular immunotherapeutic approachesInnate immune systemVirus-infected cellsInfected targetsPluripotent stem cellsImmunotherapeutic approachesNatural killerKiller cellsCell-based therapiesT cells
2009
Natural Killer Cells Derived From Human Pluripotent Stem Cells Provide a Novel Method to Treat HIV-1 Infection.
Ni Z, Knorr D, Clouser C, Southern P, Mansky L, Park I, Kaufman D. Natural Killer Cells Derived From Human Pluripotent Stem Cells Provide a Novel Method to Treat HIV-1 Infection. Blood 2009, 114: 280. DOI: 10.1182/blood.v114.22.280.280.Peer-Reviewed Original ResearchHIV-1-infected targetsNatural killer cellsHIV-1 infectionHuman CD4 T cellsUmbilical cord blood progenitor cellsNK cell populationNK cellsPrimary human CD4 T cellsCD4 T cellsBlood progenitor cellsHIV-1 replicationCord blood progenitor cellsKiller cellsT cellsUninfected targetsProgenitor cellsHIV-1-infected cell linesAcute HIV-1 infectionHIV-1-infected cellsAntibody-dependent cellular cytotoxicityHIV-1 NL4-3Human umbilical cord blood progenitor cellsTumor cellsExpression of CD107aIPSC-NK cells