2020
Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model
Noh JE, Oh SH, Park IH, Song J. Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model. Frontiers In Cellular Neuroscience 2020, 14: 546659. PMID: 33100972, PMCID: PMC7546889, DOI: 10.3389/fncel.2020.546659.Peer-Reviewed Original ResearchHuman umbilical cord-derived mesenchymal stromal cellsMiddle cerebral artery occlusionMesenchymal stromal cellsSubacute phaseRodent modelsUmbilical cord-derived mesenchymal stromal cellsStromal cellsIschemic penumbra regionCerebral artery occlusionGlial scar formationDelivery modeSame time pointsHuman umbilical cordStem cell therapyCandidate cell typesInfarct volumeArtery occlusionIschemic strokeIntracerebral transplantsTransplanted ratsCell-based therapiesChronic phaseFunctional recoveryTherapeutic effectBehavioral deficits
2010
Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms. Journal Of Virology 2010, 85: 43-50. PMID: 20962093, PMCID: PMC3014194, DOI: 10.1128/jvi.01774-10.Peer-Reviewed Original ResearchConceptsNK cellsHIV/AIDSAnti-HIV-1 immunityHIV-1-infected individualsAntibody-dependent cellular cytotoxicityTumor cellsCEM-GFP cellsFunctional NK cellsAnti-HIV-1 activityNatural killer cellsHIV-1 infectionProduction of chemokinesCellular mechanismsHIV-1 replicationStem cellsCellular immunotherapeutic approachesInnate immune systemVirus-infected cellsInfected targetsPluripotent stem cellsImmunotherapeutic approachesNatural killerKiller cellsCell-based therapiesT cells