Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells
MacLean G, Menne T, Park I, Daley G, Orkin S. Altered Hematopoiesis in Trisomy 21 As Revealed Through In Vitro Differentiation of Isogenic Human Pluripotent Cells. Blood 2011, 118: 921. DOI: 10.1182/blood.v118.21.921.921.Peer-Reviewed Original ResearchTrisomy 21Trisomic cellsFetal liverAdvisory CommitteeGATA1 mutationsPre-leukemic conditionAcute myeloid leukemiaTransient myeloproliferative disorderTrisomy 21 resultsCell linesDisomic controlsSomatic mutationsCFU-M coloniesColony forming assaysMultilineage hematopoietic progenitor cellsQuantitative RT-PCRHematopoietic progenitor cellsIL-6Myeloid leukemiaMouse modelMyeloproliferative disordersMegakaryoblastic leukemiaProgenitor populationsMyeloid progenitor populationsCD31/CD34