Humanized murine model for HBV and HCV using human induced pluripotent stem cells
Zhou XL, Sullivan GJ, Sun P, Park IH. Humanized murine model for HBV and HCV using human induced pluripotent stem cells. Archives Of Pharmacal Research 2012, 35: 261-269. PMID: 22370780, PMCID: PMC3731984, DOI: 10.1007/s12272-012-0206-8.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusMouse modelHepatocellular carcinomaHuman hepatocytesPathogenesis of HBVVivo transgenic mouse modelAcute asymptomatic infectionsStem cellsHumanized murine modelHumanized mouse modelHuman HCC cell linesNovel mouse modelTransgenic mouse modelPluripotent stem cellsHCC cell linesHuman primary hepatocytesPrimary human hepatocytesAsymptomatic infectionC virusChronic infectionB virusSusceptibility of hepatocytesImmunodeficient miceMurine model