High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties
Zhang J, Rajendran B, Desai S, Gibson J, DiPalermo J, LoRusso P, Kong Y, Zhao H, Cecchini M, Schalper K. High MGMT expression identifies aggressive colorectal cancer with distinct genomic features and immune evasion properties. Journal For ImmunoTherapy Of Cancer 2025, 13: e011653. PMID: 40935566, DOI: 10.1136/jitc-2025-011653.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesCD8+ tumor-infiltrating lymphocytesPromoter methylation statusMGMT expressionMGMT overexpressionClinical significanceAllogeneic peripheral blood mononuclear cellsCD8+ T cellsMGMT promoter methylation statusKilling of malignant cellsMGMT-expressing cellsMultiplexed quantitative immunofluorescencePeripheral blood mononuclear cellsAggressive clinical courseMGMT protein expressionAggressive colorectal cancerMethylation statusExpression of MGMTLevels of MGMT proteinMGMT protein levelsImmune evasion propertiesBlood mononuclear cellsMutational featuresAdaptive immune evasionSomatic mutation burden
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