2013
A Major Epigenetic Programming Mechanism Guided by piRNAs
Huang XA, Yin H, Sweeney S, Raha D, Snyder M, Lin H. A Major Epigenetic Programming Mechanism Guided by piRNAs. Developmental Cell 2013, 24: 502-516. PMID: 23434410, PMCID: PMC3600162, DOI: 10.1016/j.devcel.2013.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArgonaute ProteinsChromatinChromatin ImmunoprecipitationChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNA Transposable ElementsDrosophilaDrosophila ProteinsEpigenomicsGenomeGenomicsMethyltransferasesMutationReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA Polymerase IIRNA, MessengerRNA, Small InterferingConceptsSpecific genomic sitesEpigenetic factorsGenomic sitesRNA polymerase II associationPiwi-piRNA complexDrosophila genomeEpigenetic stateEpigenetic landscapeComplex associatesPiwiGenomePiRNAsCentral enigmaMajor mechanismEctopic sitesSequenceHP1aDrosophilaPiRNASitesEpigeneticsMechanismProgramming mechanismAssociatesRecruitment
2010
Identification of Piwil2-Like (PL2L) Proteins that Promote Tumorigenesis
Ye Y, Yin DT, Chen L, Zhou Q, Shen R, He G, Yan Q, Tong Z, Issekutz AC, Shapiro CL, Barsky SH, Lin H, Li JJ, Gao JX. Identification of Piwil2-Like (PL2L) Proteins that Promote Tumorigenesis. PLOS ONE 2010, 5: e13406. PMID: 20975993, PMCID: PMC2958115, DOI: 10.1371/journal.pone.0013406.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsBase SequenceCell Line, TumorCell Transformation, NeoplasticDNA PrimersFemaleHumansImmunohistochemistryMaleMiceMice, Inbred C57BLNeoplasm MetastasisNeoplasmsNF-kappa BPrecancerous ConditionsProteinsProto-Oncogene Proteins c-bcl-2Reverse Transcriptase Polymerase Chain ReactionRNA InterferenceRNA, MessengerSTAT3 Transcription FactorStem CellsTransplantation, HeterologousUp-RegulationConceptsGermline stem cellsStem cellsAGO gene familyCell cycle entryPrecancerous stem cellsTumor developmentTumor cell survivalBCL2 gene expressionGene familyCycle entryGene expressionTumor cellsNF-κBCell survivalAnticancer drug developmentPIWIL2S phaseGene exonsNovel insightsProteinMouse tumor cellsCancer developmentNovel monoclonal antibodyTranscriptsTypes of human