2025
Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness
Parikh R, Nayak D, Lin H, Gangaraju V. Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness. Journal Of Biological Chemistry 2025, 108210. PMID: 39848495, DOI: 10.1016/j.jbc.2025.108210.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsDevelopmental robustnessTE silencingSilencing of transposable elementsP-element induced wimpy testisPreserving genome integrityHistone 3 lysineIntrinsic genetic variationPost-transcriptional silencingMammalian nucleolinTransposon RNAsTransposon silencingPiRNA functionPiwi-piRNATE activityGenomic sitesMaternal germlineArgonaute 3Genome integrityTranscriptional silencingGenetic variationEpigenetic regulationPIWIBinding protein
2015
Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress
Ge XQ, Han J, Cheng EC, Yamaguchi S, Shima N, Thomas JL, Lin H. Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress. Stem Cell Reports 2015, 5: 185-194. PMID: 26190528, PMCID: PMC4618655, DOI: 10.1016/j.stemcr.2015.06.002.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsStem/progenitor cellsNeural stem/progenitor cellsStem cellsProgenitor cellsTissue stem/progenitor cellsMCM2-7 complexDNA replication originsTissue-specific stem/progenitor cellsStem cell typesGenome integrityGenomic integrityReplication stressDormant originsReplication forksReplicative stressDNA replicationReplication originsNeural lineagesDNA damageS phaseCell typesAbnormal neurogenesisCellsGenome
2011
Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms
Juliano C, Wang J, Lin H. Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms. Annual Review Of Genetics 2011, 45: 447-469. PMID: 21942366, PMCID: PMC3832951, DOI: 10.1146/annurev-genet-110410-132541.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsDiverse organismsStem cellsArgonaute protein familyPIWI-piRNA pathwayStem cell maintenanceSomatic stem/progenitor cellsAdult stem cellsStem/progenitor cellsPiRNA pathwayGermline specificationAnimal phylogenyGenome integrityProtein familyPosttranscriptional regulationCell maintenanceProtein bindsSomatic cellsEpigenetic programmingGermlineProgenitor cellsProteinOrganismsCommon mechanism