Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth
Bryan B, Cai Y, Wrighton K, Wu G, Feng X, Liu M. Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth. FEBS Letters 2005, 579: 1015-1019. PMID: 15710384, DOI: 10.1016/j.febslet.2004.12.074.Peer-Reviewed Original ResearchConceptsRhoA protein levelsNeurite outgrowthE3 ubiquitin ligaseProteasome inhibitor MG132Protein levelsNon-neuronal cell typesIntracellular asymmetryCell polarityRho familyRho GTPasesUbiquitin ligasePromotes Neurite OutgrowthSubsequent ubiquitinationProteasomal degradationProtrusive activityEssential regulatorInhibitor MG132RhoA activitySmurf1Axonal pathfindingUbiquitinationNeuro2a cellsRhoACell typesProtrusion sites