2023
Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo
Akingbesote N, Leitner B, Jovin D, Desrouleaux R, Owusu D, Zhu W, Li Z, Pollak M, Perry R. Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo. ELife 2023, 12: e78335. PMID: 37219930, PMCID: PMC10205083, DOI: 10.7554/elife.78335.Peer-Reviewed Original ResearchConceptsMetabolic scalingMetabolic fluxMetabolic processesBody sizeMitochondrial metabolic processesMultiple cellular compartmentsVivo metabolic fluxesLevel of genesKey metabolic pathwaysProtein expressionMetabolic flux analysisAspects of metabolismCellular compartmentsGene expressionDifferential expressionMetabolic pathwaysGenesFlux analysisOxidative damageEnzyme activitySubstrate supplyFold rangeSpeciesExpressionMetabolic rate
2022
Vascular pathobiology of pulmonary hypertension
Gallardo-Vara E, Ntokou A, Dave J, Jovin D, Saddouk F, Greif D. Vascular pathobiology of pulmonary hypertension. The Journal Of Heart And Lung Transplantation 2022, 42: 544-552. PMID: 36604291, PMCID: PMC10121751, DOI: 10.1016/j.healun.2022.12.012.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionCell typesSmooth muscle cell proliferationEndothelial cell dysfunctionMuscle cell proliferationKruppel-like factor 4Extracellular matrix remodelingHypoxia-inducible factorBox proteinBlood pressurePulmonary arteryInflammatory cellsPulmonary vasculatureMain cell typesVascular pathogenesisVasoactive moleculesCell dysfunctionClinical impactVascular pathobiologyPathological remodelingIntercellular crosstalkLethal diseaseMesenchymal transitionMatrix remodelingGrowth factorFlow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner.
Shin J, Hong SG, Choi SY, Rath ME, Saredy J, Jovin DG, Sayoc J, Park HS, Eguchi S, Rizzo V, Scalia R, Wang H, Houser SR, Park JY. Flow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner. Redox Biol 2022, 50: 102252. PMID: 35121402, DOI: 10.1016/j.redox.2022.102252.Peer-Reviewed Original Research
2021
Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy.
Torrado J, Kowlgi GN, Ramirez RJ, Balderas-Villalobos J, Jovin D, Parker C, Om E, Airapetov S, Kaszala K, Tan AY, Ellenbogen KA, Huizar JF. Eccentric hypertrophy in an animal model of mid- and long-term premature ventricular contraction-induced cardiomyopathy. Heart Rhythm O2 2021, 2: 80-88. PMID: 34113908, DOI: 10.1016/j.hroo.2020.12.021.Peer-Reviewed Original Research
2020
Coronary artery bypass graft markers: history, usage, and effects.
Jovin DG, Katlaps GJ, Sumption KF. Coronary artery bypass graft markers: history, usage, and effects. Gen Thorac Cardiovasc Surg 2020, 68: 453-458. PMID: 32146580, DOI: 10.1007/s11748-020-01325-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes.
Gunda S, Akyeampong D, Gomez-Arroyo J, Jovin DG, Kowlgi NG, Kaszala K, Tan AY, Koneru JN, Kron J, Ellenbogen KA, Huizar JF. Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes. J Cardiovasc Electrophysiol 2019, 30: 1952-1959. PMID: 31310360, DOI: 10.1111/jce.14067.Peer-Reviewed Original Research