Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entry.
Choi J, Speckhart K, Tsai B, DiMaio D. Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entry. MBio 2024, e0281124. PMID: 39431827, DOI: 10.1128/mbio.02811-24.Peer-Reviewed Original ResearchRab proteinsDNA virusesVirus entryHPV traffickingIntra-Golgi transportTrans-Golgi networkIntracellular vesicular transportMotor protein complexInfected cellsIntra-GolgiL2 capsid proteinRab GTPasesDynein adaptorsNon-enveloped DNA virusesRetrograde traffickingGolgi apparatusPotential targetProtein complexesVesicular transportRab6ADyneinTGNCapsid proteinRabCellular enzymesThe BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection
Speckhart K, Choi J, DiMaio D, Tsai B. The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection. PLOS Pathogens 2024, 20: e1012289. PMID: 38829892, PMCID: PMC11230635, DOI: 10.1371/journal.ppat.1012289.Peer-Reviewed Original ResearchTrans Golgi networkL2 capsid proteinPromote infectionCapsid proteinIn vitro binding studiesDynein adaptorsGolgi networkCargo adaptorsBICD2 functionDynein motorsC-terminusDyneinSupport infectionMolecular basisBICD2EndosomesAdaptorProteinBinding studiesCell-basedVirusShort segmentHuman papillomavirusGolgiInfection