Chengye Feng
Postdoctoral AssociateAbout
Research
Publications
Featured Publications
Patronin-mediated minus end growth is required for dendritic microtubule polarity.
Feng C, Thyagarajan P, Shorey M, Seebold DY, Weiner AT, Albertson RM, Rao KS, Sagasti A, Goetschius DJ, Rolls MM. Patronin-mediated minus end growth is required for dendritic microtubule polarity. J Cell Biol 2019, 218: 2309-2328. PMID: 31076454, DOI: 10.1083/jcb.201810155.Peer-Reviewed Original Research
2023
Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
Khazma T, Grossman A, Guez-Haddad J, Feng C, Dabas H, Sain R, Weitman M, Zalk R, Isupov M, Hammarlund M, Hons M, Opatowsky Y. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Reports 2023, 42: 113026. PMID: 37635352, PMCID: PMC10675840, DOI: 10.1016/j.celrep.2023.113026.Peer-Reviewed Original ResearchConceptsC. elegansCryoelectron microscopy structureNematode C. elegansC. elegans neuronsStructure-function analysisMicroscopy structureNADase activityMolecular mechanismsElegansCellular NADModel animalsSpeciesAxon degenerationWallerian axonal degenerationOrthologsOctamerProteinSARM1DivergenceNADSARMExpressionActivityAxonal degeneration
2022
Microtubule polarity is instructive for many aspects of neuronal polarity.
Thyagarajan P, Feng C, Lee D, Shorey M, Rolls MM. Microtubule polarity is instructive for many aspects of neuronal polarity. Dev Biol 2022, 486: 56-70. PMID: 35341730, DOI: 10.1016/j.ydbio.2022.03.009.Peer-Reviewed Original Research
2021
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules.
Feng C, Cleary JM, Kothe GO, Stone MC, Weiner AT, Hertzler JI, Hancock WO, Rolls MM. Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules. J Cell Sci 2021, 134 PMID: 34096607, DOI: 10.1242/jcs.258437.Peer-Reviewed Original ResearchMicrotubule dynamics in healthy and injured neurons.
Rolls MM, Thyagarajan P, Feng C. Microtubule dynamics in healthy and injured neurons. Dev Neurobiol 2021, 81: 321-332. PMID: 32291942, DOI: 10.1002/dneu.22746.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites.
Weiner AT, Seebold DY, Michael NL, Guignet M, Feng C, Follick B, Yusko BA, Wasilko NP, Torres-Gutierrez P, Rolls MM. Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites. G3 (Bethesda) 2018, 8: 1841-1853. PMID: 29602811, DOI: 10.1534/g3.118.200205.Peer-Reviewed Original Research
2016
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
Jegla T, Nguyen MM, Feng C, Goetschius DJ, Luna E, van Rossum DB, Kamel B, Pisupati A, Milner ES, Rolls MM. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. PLoS Genet 2016, 12: e1006457. PMID: 27911898, DOI: 10.1371/journal.pgen.1006457.Peer-Reviewed Original ResearchThe microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration.
Tao J, Feng C, Rolls MM. The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration. J Cell Sci 2016, 129: 3274-81. PMID: 27411367, DOI: 10.1242/jcs.188540.Peer-Reviewed Original Research
2013
Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.
He M, Zhang L, Wang X, Huo L, Sun L, Feng C, Jing X, Du D, Liang H, Liu M, Hong Z, Zhou J. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. PLoS One 2013, 8: e67186. PMID: 23826228, DOI: 10.1371/journal.pone.0067186.Peer-Reviewed Original Research