From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons
Neely M, Davison C, Aschner M, Bowman A. From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicological Sciences 2017, 159: 366-379. PMID: 28962525, PMCID: PMC5837701, DOI: 10.1093/toxsci/kfx145.Peer-Reviewed Original ResearchConceptsReactive oxygen/nitrogen speciesOxygen/nitrogen speciesOxidative stress signatureDichlorodihydrofluorescein diacetate (DCFHDA) assayNitrogen speciesCellular oxidative stressOverall neuronal healthParkinson's diseaseOxidative stress endpointsCellular reduced glutathioneImpaired mitochondrial activityOxidative stressHuman dopamine neuronsDopamine neuronsOutcome measuresEnvironmental stressorsMitochondrial activityStress signatureStress endpointsNeuronal healthMesencephalic dopamine neuronsPD pathogenesisNeurite lengthMechanism of actionSpecies