1991
Inherited Hepatic Enzyme Defects as Candidates for Liver-Directed Gene Therapy
Horwich A. Inherited Hepatic Enzyme Defects as Candidates for Liver-Directed Gene Therapy. Current Topics In Microbiology And Immunology 1991, 168: 185-200. PMID: 1893777, DOI: 10.1007/978-3-642-76015-0_9.Peer-Reviewed Original Research
1990
Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
Summers J, Smith P, Horwich A. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. Journal Of Virology 1990, 64: 2819-2824. PMID: 2335817, PMCID: PMC249463, DOI: 10.1128/jvi.64.6.2819-2824.1990.Peer-Reviewed Original ResearchConceptsCccDNA synthesisEnvelope proteinVirus-mediated cell deathHepadnavirus envelope proteinsCircular DNA amplificationViral DNA synthesisWild-type virusWild typeViral envelope proteinsCell deathCircular DNAPrimary duck hepatocytesDNA synthesisProteinDNA amplificationPersistent infectionDuck hepatocytesSynthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells
Horwich A, Furtak K, Pugh J, Summers J. Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells. Journal Of Virology 1990, 64: 642-650. PMID: 2153230, PMCID: PMC249155, DOI: 10.1128/jvi.64.2.642-650.1990.Peer-Reviewed Original ResearchConceptsHepatitis B virus genomeDirect repeat 1Duck hepatitis B virus genomesInfectious virusViral DNA synthesisVirus antigen productionCore antigenDNA-containing viral particlesHepatoma cell line Huh7Human hepatoma cell line Huh7Cultured Huh7 cellsDNA synthesisVirus genomeAntigen productionHuh7 cellsEnvelope proteinViral particlesLoss of abilityViral DNA