CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis
Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui J, Chen X, Hui E. CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. Journal Of Experimental Medicine 2023, 220: e20221391. PMID: 37042938, PMCID: PMC10103642, DOI: 10.1084/jem.20221391.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAntigens, CDAntigens, DifferentiationB7-1 AntigenB7-2 AntigenCD28 AntigensCell Adhesion MoleculesCTLA-4 AntigenHumansImmunoconjugatesLigandsMembrane GlycoproteinsConceptsT cellsMajor histocompatibility complexB7 ligandsHuman regulatory T cellsRegulatory T cellsSurface of T cellsCD28 costimulatory signalsAntigen-presenting-cellsAdaptive immune responsesHuman T cellsT cell coreceptorsCostimulatory signalsLigands CD80CTLA4Cell-intrinsicImmune responseCD28Histocompatibility complexTrogocytosisCD28:B7TregsCD80CD86Extrinsic functionsBlockade