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Todd Constable, PhD

Professor of Radiology and Biomedical Imaging and of Neurosurgery; Director MRI Research

Research Summary

My research is focused on developing and validating novel approaches to functional Magnetic Resonance Imaging (fMRI) and using these methods to improve our understanding of brain function. This work includes approaches for quantitative neuroimaging and methods for assessing brain function via connectivity mapping. These developments are applied in the neurosurgical environment to localizing epileptogenic tissue and mapping function prior to surgical intervention. These studies provide a framework for validating the fMRI techniques through comparisons with cortical stimulation, behavioral analyses, Wada testing, and patient outcomes. They also improve our understanding of the link between fMRI signal changes and neuronal activity, through comparisons of fMRI in vivo with EEG/ERP recordings obtained in patients with depth electrodes and/or subdural grids. We are also interested in better understanding basic language and memory processing in humans and factors that influence the networks revealed by neuroimaging.

Specialized Terms: Development of MRI techniques to allow faster scanning and/or to provide functional information; Quantitative information and high quality pictures of anatomy; Application of new methods to answer fundamental questions in basic science and medicine with emphasis on applications in neuroscience.

Extensive Research Description

Dr. Todd Constable's research primarily focuses on functional magnetic resonance (MR) and understanding cognitive processes that are related to language and memory and how these processes may be altered in different disease states or with different medications. An important aspect of some of the imaging techniques he is developing is the ability to separate indirect physiologic changes associated with particular diseases or medications from those that directly impact neuronal processes.

Coauthors

Research Interests

Anatomy; Diagnostic Imaging; Magnetic Resonance Imaging; Neurosurgery; Radiology; Neuroimaging

Selected Publications

  • Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among childrenLin H, Haider S, Kaltenhauser S, Mozayan A, Malhotra A, Constable R, Scheinost D, Ment L, Konrad K, Payabvash S. Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children Frontiers In Neuroscience 2023, 17: 1138670. PMCID: PMC9992191, DOI: 10.3389/fnins.2023.1138670.
  • Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disordersColic L, Villa L, Dauvermann M, Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Quatrano S, Spencer L, Constable R, Suckling J, Goodyer I, Schmaal L, Harmelen A, Blumberg H. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders JCPP Advances 2022, 2 DOI: 10.1002/jcv2.12118.
  • A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar DisorderGoldman D, Sankar A, Colic L, Villa L, Kim J, Pittman B, Constable R, Scheinost D, Blumberg H. A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder Biological Psychiatry 2022, 91: s38-s39. DOI: 10.1016/j.biopsych.2022.02.114.
  • P350. Brain Structural Covariation Relates Longitudinally to Screen Media Activity and Internalizing Psychopathology in ChildrenZhao Y, Paulus M, Bagot K, Constable R, Potenza M. P350. Brain Structural Covariation Relates Longitudinally to Screen Media Activity and Internalizing Psychopathology in Children Biological Psychiatry 2022, 91: s228-s229. DOI: 10.1016/j.biopsych.2022.02.586.
  • Fluorescently-Tagged Magnetic Protein Nanoparticles for High-Resolution Optical and Ultra-High Field Magnetic Resonance Dual-Modal Cerebral AngiographyMishra S, Mishra S, Herman P, Crair M, Constable R, Constable R, Walsh J, Walsh J, Akif A, Verhagen J, Verhagen J, Hyder F. Fluorescently-Tagged Magnetic Protein Nanoparticles for High-Resolution Optical and Ultra-High Field Magnetic Resonance Dual-Modal Cerebral Angiography Nanoscale 2022 DOI: 10.1039/d2nr04878g.
  • A Graph Theoretical Connectome Measure to Assess Whole Brain Functional Connectivity Disturbances Associated With Suicide Attempts in Bipolar DisorderSankar A, Scheinost D, Goldman D, Drachman R, Colic L, Villa L, Kim J, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie C, Oquendo M, Constable R, Blumberg H. A Graph Theoretical Connectome Measure to Assess Whole Brain Functional Connectivity Disturbances Associated With Suicide Attempts in Bipolar Disorder Biological Psychiatry 2021, 89: s296. DOI: 10.1016/j.biopsych.2021.02.737.
  • Associations Between Trauma Exposure, Internalizing Symptoms, and Functional Connectivity in YouthSisk L, Conley M, Greene A, Horien C, Rapuano K, Rosenberg M, Scheinost D, Constable R, Casey B, Gee D. Associations Between Trauma Exposure, Internalizing Symptoms, and Functional Connectivity in Youth Biological Psychiatry 2021, 89: s323-s324. DOI: 10.1016/j.biopsych.2021.02.806.
  • Individual Differences in the Functional Organization of InfantsScheinost D, Salehi M, Constable R, Spann M. Individual Differences in the Functional Organization of Infants Biological Psychiatry 2021, 89: s78. DOI: 10.1016/j.biopsych.2021.02.208.
  • Identifying Individual Differences in the Functional Organization of the Neonatal BrainScheinost D, Salehi M, Constable R, Spann M. Identifying Individual Differences in the Functional Organization of the Neonatal Brain Biological Psychiatry 2020, 87: s82. DOI: 10.1016/j.biopsych.2020.02.231.
  • Mood State Differences in Intrinsic Connectivity Distribution of Adolescents and Young Adults With Bipolar DisorderGoldman D, Sankar A, Colic L, Spencer L, Lacadie C, Scheinost D, Constable R, Blumberg H. Mood State Differences in Intrinsic Connectivity Distribution of Adolescents and Young Adults With Bipolar Disorder Biological Psychiatry 2020, 87: s416-s417. DOI: 10.1016/j.biopsych.2020.02.1063.
  • Preliminary Phenotypic Feature Capture During Clinical InteractionBarron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
  • What Can Machine Learning Do for Psychiatry?Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
  • Differential resting state connectivity responses to glycemic state in type 1 diabetesParikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang J. Differential resting state connectivity responses to glycemic state in type 1 diabetes The Journal Of Clinical Endocrinology & Metabolism 2019 DOI: 10.1210/jcem/dgz004.
  • S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional ConnectivityBarron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
  • Chapter 4 The uniqueness of the individual functional connectomeHorien C, Scheinost D, Constable R. Chapter 4 The uniqueness of the individual functional connectome 2019, 63-81. DOI: 10.1016/b978-0-12-813838-0.00004-2.
  • 79. Transdiagnostic Prediction of Memory and Cognitive Abilities From Functional Connectivity Data: A Multidimensional Connectome-Based Predictive Modeling StudyScheinost D, Gao S, Greene A, Constable R. 79. Transdiagnostic Prediction of Memory and Cognitive Abilities From Functional Connectivity Data: A Multidimensional Connectome-Based Predictive Modeling Study Biological Psychiatry 2018, 83: s33. DOI: 10.1016/j.biopsych.2018.02.096.
  • Task Integration for Connectome-Based Prediction Via Canonical Correlation AnalysisGao S, Greene A, Constable R, Scheinost D. Task Integration for Connectome-Based Prediction Via Canonical Correlation Analysis 2018, 87-91. DOI: 10.1109/isbi.2018.8363529.
  • A Submodular Approach to Create Individualized Parcellations of the Human BrainSalehi M, Karbasi A, Scheinost D, Constable R. A Submodular Approach to Create Individualized Parcellations of the Human Brain 2017, 10433: 478-485. DOI: 10.1007/978-3-319-66182-7_55.
  • Sex differences in intrinsic connectivity during FMRI stroop in cocaine-dependent and healthy comparison subjectsMitchell M, DeVito E, Balodis I, Lacadie C, Scheinost D, Constable R, Malison R, Carroll K, Potenza M. Sex differences in intrinsic connectivity during FMRI stroop in cocaine-dependent and healthy comparison subjects Drug And Alcohol Dependence 2015, 156: e154. DOI: 10.1016/j.drugalcdep.2015.07.419.
  • Radiofrequency pulse design using nonlinear gradient magnetic fieldsKopanoglu E, Constable R. Radiofrequency pulse design using nonlinear gradient magnetic fields Magnetic Resonance In Medicine 2015, 74: spcone-spcone. DOI: 10.1002/mrm.25909.
  • Accelerate Single-Shot Data Acquisitions Using Compressed Sensing and Fronsac ImagingWang H, Constable R, Galiana G. Accelerate Single-Shot Data Acquisitions Using Compressed Sensing and Fronsac Imaging 2015, 1252-1255. DOI: 10.1109/isbi.2015.7164101.
  • Methodological Issues in fMRI Functional Connectivity and Network AnalysisFinn E, Scheinost D, Shen X, Papademetris X, Constable R. Methodological Issues in fMRI Functional Connectivity and Network Analysis 2015, 697-704. DOI: 10.1016/b978-0-12-397025-1.00352-3.
  • MRI and fMRI Optimizations and ApplicationsCiris P, Constable R. MRI and fMRI Optimizations and Applications 2015, 183-190. DOI: 10.1016/b978-0-12-397025-1.00021-x.
  • Challenges in fMRI and Its LimitationsConstable R. Challenges in fMRI and Its Limitations 2014, 51-69. DOI: 10.1007/978-1-4939-1995-6_4.
  • Functional Connectivity MR ImagingHampson M, Shen X, Constable R. Functional Connectivity MR Imaging 2014, 83-104. DOI: 10.1007/978-1-4939-1995-6_6.
  • Accelerate Data Acquisition using Turbo Spin Echo and O-SpaceWang H, Tam L, Kopanoglu E, Peters D, Constable R, Galiana G. Accelerate Data Acquisition using Turbo Spin Echo and O-Space 2014, 874-877. DOI: 10.1109/isbi.2014.6868010.
  • Coupled Intrinsic Connectivity: A Principled Method for Exploratory Analysis of Paired DataScheinost D, Shen X, Finn E, Sinha R, Constable R, Papademetris X. Coupled Intrinsic Connectivity: A Principled Method for Exploratory Analysis of Paired Data 2013, 219-227. DOI: 10.1007/978-3-319-02475-2_20.
  • Cardiac cine with ART for radial parallel imaging reconstructionLi S, Galiana G, Tam L, Kozerke S, Stockmann J, Constable R, Peters D. Cardiac cine with ART for radial parallel imaging reconstruction Journal Of Cardiovascular Magnetic Resonance 2013, 15: e34. PMCID: PMC3559413, DOI: 10.1186/1532-429x-15-s1-e34.
  • Challenges in fMRI and Its LimitationsConstable R. Challenges in fMRI and Its Limitations 2011, 331-344. DOI: 10.1007/978-1-4419-0345-7_19.
  • Functional Connectivity MR ImagingHampson M, Shen X, Constable R. Functional Connectivity MR Imaging 2011, 355-371. DOI: 10.1007/978-1-4419-0345-7_21.
  • SU‐GG‐J‐150: Analyses of Multiple Q‐Sampled Diffusion Tensor Amplitudes for Pseudoprogressive GBMChu A, Knisely J, Constable R, Fulbright R, Nath R. SU‐GG‐J‐150: Analyses of Multiple Q‐Sampled Diffusion Tensor Amplitudes for Pseudoprogressive GBM Medical Physics 2010, 37: 3180-3180. DOI: 10.1118/1.3468373.
  • Challenges in fMRI and Its LimitationsConstable R. Challenges in fMRI and Its Limitations 2010, 71-92. DOI: 10.1007/978-1-4419-1329-6_4.
  • Les coils d’angiographie en résonnance magnétique implantés chirurgicalement améliorent la résolution et permettent la visualisation dynamique du flux sanguinFitzgerald T, Muto A, Fancher T, Brown P, Martin K, Muhs B, Rothman D, Constable R, Sampath S, Dardik A. Les coils d’angiographie en résonnance magnétique implantés chirurgicalement améliorent la résolution et permettent la visualisation dynamique du flux sanguin Annales De Chirurgie Vasculaire 2010, 24: 266-277. DOI: 10.1016/j.acvfr.2010.09.010.
  • Technical Comparison of ARTOP/ADC as a Clinical Treatment Response PredictorChu A, Knisely J, Fulbright R, Constable R, Nath R. Technical Comparison of ARTOP/ADC as a Clinical Treatment Response Predictor International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s614. DOI: 10.1016/j.ijrobp.2009.07.1404.
  • Q Space Analysis of Glioma Diffusion Tensor Imaging (DTI) for Treatment Response MonitoringKnisely J, Chu A, Fulbright R, Constable R. Q Space Analysis of Glioma Diffusion Tensor Imaging (DTI) for Treatment Response Monitoring International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s245. DOI: 10.1016/j.ijrobp.2009.07.564.
  • Voxel Based Intrinsic Connectivity Changes with AgeTokoglu F, Hampson M, Constable R. Voxel Based Intrinsic Connectivity Changes with Age NeuroImage 2009, 47: s60. DOI: 10.1016/s1053-8119(09)70273-3.
  • Intrinsic Connectivity Contrast: A Voxel Level Summary of Tissue ConnectivityConstable, Hara Y, Tokoglu F, Papademetris X. Intrinsic Connectivity Contrast: A Voxel Level Summary of Tissue Connectivity NeuroImage 2009, 47: s186. DOI: 10.1016/s1053-8119(09)72066-x.
  • SU‐FF‐J‐134: Slow Diffusion Enhancement for Approximated Returning to the Origin Probability (ARTOP)Chu A, Knisely J, Constable R, Fulbright R, Nath R. SU‐FF‐J‐134: Slow Diffusion Enhancement for Approximated Returning to the Origin Probability (ARTOP) Medical Physics 2009, 36: 2507-2507. DOI: 10.1118/1.3181426.
  • SU‐FF‐J‐140: Multiple Aspects of Approximated‐Returning‐To‐The‐Origin Probability (ARTOP) Diffusion Tensor Imaging for Better Observation High‐Graded Gliomas Treatment ResponsesChu A, Knisely J, Fulbright R, Constable R, Nath R. SU‐FF‐J‐140: Multiple Aspects of Approximated‐Returning‐To‐The‐Origin Probability (ARTOP) Diffusion Tensor Imaging for Better Observation High‐Graded Gliomas Treatment Responses Medical Physics 2009, 36: 2509-2509. DOI: 10.1118/1.3181432.
  • Caractérisation du tenseur de diffusion basée sur un modèle toroïdal : application à la structure cérébrale et perspectivesMétellus P, Mekkaoui C, Todd A, Constable R, Jackowski M. Caractérisation du tenseur de diffusion basée sur un modèle toroïdal : application à la structure cérébrale et perspectives Neurochirurgie 2008, 54: 682-683. DOI: 10.1016/j.neuchi.2008.08.054.
  • Approximated Returning-to-origin Probability Diffusion Imaging for Better Observation of Radiation Treatment Response of High-grade GliomaChu A, Knisely J, Fulbright R, Constable R, Nath R. Approximated Returning-to-origin Probability Diffusion Imaging for Better Observation of Radiation Treatment Response of High-grade Glioma International Journal Of Radiation Oncology • Biology • Physics 2008, 72: s536. DOI: 10.1016/j.ijrobp.2008.06.075.
  • Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamicsFitzgerald T, Muto A, Fancher T, Brown P, Martin K, Muhs B, Rothman D, Constable R, Sampath S, Dardik A. Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics Journal Of The American College Of Surgeons 2008, 207: s113. DOI: 10.1016/j.jamcollsurg.2008.06.292.
  • SU‐GG‐I‐125: Treatment Responses Monitored by Estimated Returning‐To‐Origin Probability for Clinical High Diffusion ImageChu A, Knisely J, Fulbright R, Constable R, Nath R. SU‐GG‐I‐125: Treatment Responses Monitored by Estimated Returning‐To‐Origin Probability for Clinical High Diffusion Image Medical Physics 2008, 35: 2670-2671. DOI: 10.1118/1.2961523.
  • Correction to Haas, Omura, Constable, and Canli (2007)Haas B, Omura K, Constable R, Canli T. Correction to Haas, Omura, Constable, and Canli (2007) Behavioral Neuroscience 2007, 121: 1173-1173. DOI: 10.1037/0735-7044.121.6.1173.
  • Early Detection of Glioblastoma Multiforme Treatment Response Using Magnetic Resonance Imaging Assisted by Slow Water Diffusion MappingChu A, Knisely J, Constable R, Fulbright R, Nath R. Early Detection of Glioblastoma Multiforme Treatment Response Using Magnetic Resonance Imaging Assisted by Slow Water Diffusion Mapping International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s635. DOI: 10.1016/j.ijrobp.2007.07.1970.
  • Dynamic CSF Fraction and MAGIC VASO fMRI [PDF Not Yet Available In IEEE Xplore]Scouten A, Constable R. Dynamic CSF Fraction and MAGIC VASO fMRI [PDF Not Yet Available In IEEE Xplore] 2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC) 2007, 62-62. DOI: 10.1109/nebc.2007.4413280.
  • Development of a Research Interface for Image Guided Intervention: Initial Application to Epilepsy NeurosurgeryPapademetris X, Vives K, DiStasio M, Staib L, Neff M, Flossman S, Frielinghaus N, Zaveri H, Novotny E, Blumenfeld H, Constable R, Hetherington H, Duckrow R, Spencer S, Spencer D, Duncan J. Development of a Research Interface for Image Guided Intervention: Initial Application to Epilepsy Neurosurgery 2006, 490-493. DOI: 10.1109/isbi.2006.1624960.
  • Challenges in fMRI and Its LimitationsConstable R. Challenges in fMRI and Its Limitations 2006, 75-98. DOI: 10.1007/0-387-34665-1_4.
  • Sevoflurane 0.25 MAC Affects Association Cortex More Than Primary Cortex - fMRI Study in VolunteersRamani R, Qiu M, Shulman R, Hyder F, Constable R. Sevoflurane 0.25 MAC Affects Association Cortex More Than Primary Cortex - fMRI Study in Volunteers Journal Of Neurosurgical Anesthesiology 2005, 17: 242-243. DOI: 10.1097/01.ana.0000187752.71537.c3.
  • Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance ImagingQiu M, Ramani R, Shulman R, Hyder F, Rajeevan N, Constable R. Disturbed Coupling of rCBF, BOLD and CMRO2 in the Presence of Stimuli During Anesthesia As Revealed by Simultaneous BOLD and CBF Functional Magnetic Resonance Imaging Journal Of Neurosurgical Anesthesiology 2005, 17: 224-225. DOI: 10.1097/01.ana.0000187715.47773.67.
  • Long‐Term Memory: Do Incremental Signals Reflect Engagement of Cognitive Processes?Meltzer J, Constable R. Long‐Term Memory: Do Incremental Signals Reflect Engagement of Cognitive Processes? 2005, 257-277. DOI: 10.1002/0470020520.ch14.
  • BioImage Suite: An integrated medical image analysis suitePapademetris X, Jackowski M, Rajeevan N, Constable R, Staib L. BioImage Suite: An integrated medical image analysis suite Insight Journal 2005 DOI: 10.54294/vb5z20.
  • Effect of 0.2MAC Sevoflurane on Regional CBFRamani R, Qiu M, Hoefner E, Shulman R, Constable R. Effect of 0.2MAC Sevoflurane on Regional CBF Journal Of Neurosurgical Anesthesiology 2004, 16: 340-341. DOI: 10.1097/00008506-200410000-00049.
  • Unexpected recovery of language function after massive left-hemisphere infarct: Coordinated psycholinguistic and neuroimaging studiesShankweiler D, Palumbo L, Ni W, Mencl W, Fulbright R, Pugh K, Constable R, Harris K, Kollia B, Van Dyke J. Unexpected recovery of language function after massive left-hemisphere infarct: Coordinated psycholinguistic and neuroimaging studies Brain And Language 2004, 91: 181-182. DOI: 10.1016/j.bandl.2004.06.093.
  • Attentional bias for valenced stimuli as a function of personality in the dot-probe taskAmin Z, Constable R, Canli T. Attentional bias for valenced stimuli as a function of personality in the dot-probe task Journal Of Research In Personality 2004, 38: 15-23. DOI: 10.1016/j.jrp.2003.09.011.
  • Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor ImagingJackowski M, Kao C, Qiu M, Constable R, Staib L. Estimation of Anatomical Connectivity by Anisotropic Front Propagation and Diffusion Tensor Imaging 2004, 3217: 663-670. DOI: 10.1007/978-3-540-30136-3_81.
  • Functional MRI in EpilepsyBinder J, Achten E, Constable R, Detre J, Gaillard W, Jack C, Loring D. Functional MRI in Epilepsy Epilepsia 2002, 43: 51-63. DOI: 10.1046/j.1528-1157.2002.043s1051.x.
  • The neurobiology of dyslexiaShaywitz B, Shaywitz S, Pugh K, Fulbright R, Mencl W, Constable R, Skudlarski P, Fletcher J, Lyon G, Gore J. The neurobiology of dyslexia Clinical Neuroscience Research 2001, 1: 291-299. DOI: 10.1016/s1566-2772(01)00015-9.
  • The Active Elastic ModelPapademetris X, Constable R, Onat E, Duncan J, Sinusas A, Dione D. The Active Elastic Model 2001, 2082: 36-49. DOI: 10.1007/3-540-45729-1_4.
  • Establishing developmental trajectories and brain/behavior relations in non-impaired and reading disabled childrenPugh K, Shaywitz B, Shaywitz S, Mencl W, Jenner A, Lee J, Fulbright R, Constable R, Skudlarski P, Katz L, Lacadie C, Gore J. Establishing developmental trajectories and brain/behavior relations in non-impaired and reading disabled children NeuroImage 2001, 13: 589. DOI: 10.1016/s1053-8119(01)91932-9.
  • Comparison of near infrared optical encephalography and fMRI for assessment of language dominanceKennan R, Constable R. Comparison of near infrared optical encephalography and fMRI for assessment of language dominance NeuroImage 2001, 13: 22. DOI: 10.1016/s1053-8119(01)91365-5.
  • 17.3 Transmyocardial excimer laser revascularization results in improvement of resting myocardial flowBEDAIR H, DIONE D, ARRIGHI J, PAPADEMETRIS X, CONDOS S, CONSTABLE R, DUNCAN J, SOUFER R, SINUSAS A. 17.3 Transmyocardial excimer laser revascularization results in improvement of resting myocardial flow Journal Of Nuclear Cardiology 2001, 8: s112-s112. DOI: 10.1016/s1071-3581(01)80849-7.
  • 715 Patterns of Motor-fMRI Activation: A Classification of PlasticityCarpentier A, Constable R, Schlosser M, Piepmeier J, Spencer D, Awad I. 715 Patterns of Motor-fMRI Activation: A Classification of Plasticity Neurosurgery 2000, 47: 503-504. DOI: 10.1097/00006123-200008000-00063.
  • Phantom-based investigation of nonrigid registration constraints in mapping fMRI to anatomical MRIStudholme C, Constable R, Duncan J. Phantom-based investigation of nonrigid registration constraints in mapping fMRI to anatomical MRI Proceedings Of SPIE 2000, 3979: 448-457. DOI: 10.1117/12.387706.
  • Brain/behavior relations in working memoryMencl W, Pugh K, Shaywitz S, Shaywitz B, Fulbright R, Constable R, Skudlarski P, Katz L, Marchione K, Lacadie C, Gore J. Brain/behavior relations in working memory NeuroImage 2000, 11: s436. DOI: 10.1016/s1053-8119(00)91367-3.
  • Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory TasksShaywitz S, Shaywitz B, Pugh K, Fulbright R, Skudlarski P, Mencl W, Constable R, Naftolin F, Palter S, Marchione K, Katz L, Shankweiler D, Fletcher J, Lacadie C, Keltz M, Gore J. Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks Obstetrical & Gynecological Survey 2000, 55: 227-228. DOI: 10.1097/00006254-200004000-00021.
  • Estimating 3D Strain from 4D Cine-MRI and Echocardiography: In-Vivo ValidationPapademetris X, Sinusas A, Dione D, Constable R, Duncan J. Estimating 3D Strain from 4D Cine-MRI and Echocardiography: In-Vivo Validation 2000, 1935: 678-686. DOI: 10.1007/978-3-540-40899-4_70.
  • Volumetric Deformation Analysis Using Mechanics-Based Data Fusion: Applications in Cardiac Motion RecoveryShi P, Sinusas A, Constable R, Duncan J. Volumetric Deformation Analysis Using Mechanics-Based Data Fusion: Applications in Cardiac Motion Recovery International Journal Of Computer Vision 1999, 35: 87-107. DOI: 10.1023/a:1008163112590.
  • Recovery of Soft Tissue Object Deformation from 3D Image Sequences Using Biomechanical ModelsPapademetris X, Shi P, Dione D, Sinusas A, Constable R, Duncan J. Recovery of Soft Tissue Object Deformation from 3D Image Sequences Using Biomechanical Models 1999, 1613: 352-357. DOI: 10.1007/3-540-48714-x_28.
  • Incorporating an Image Distortion Model in Non-rigid Alignment of EPI with Conventional MRIStudholme C, Constable R, Duncan J. Incorporating an Image Distortion Model in Non-rigid Alignment of EPI with Conventional MRI 1999, 1613: 454-459. DOI: 10.1007/3-540-48714-x_45.
  • Brain function in spasmodic dysphonia: A functional MRI studyKumada M, Mencl E, Pugh K, Constable R, Bell‐Berti F, Honorof D, Gracco V. Brain function in spasmodic dysphonia: A functional MRI study The Journal Of The Acoustical Society Of America 1999, 105: 1247-1247. DOI: 10.1121/1.425983.
  • THE FUNCTIONAL NEURAL ARCHITECTURE OF COMPONENTS OF ATTENTION IN LANGUAGE PROCESSING TASKSShaywitz B, Shaywitz S, Pugh K, Fulbright R, Constable R, Mencl W, Skudlarski P, Fletcher J, Liberman A, Shankweiler D, Katz L, Marchione K, Lacadie C, Gatenby C, Klorman R, Gore J. THE FUNCTIONAL NEURAL ARCHITECTURE OF COMPONENTS OF ATTENTION IN LANGUAGE PROCESSING TASKS NeuroImage 1998, 7: s109. DOI: 10.1016/s1053-8119(18)30942-x.
  • Activation Quantitation and ROI Comparisons in Functional MRIConstable R, Skudlarski P, Mencl E, Pugh K, Fulbright R, Shaywitz S, Shaywitz B. Activation Quantitation and ROI Comparisons in Functional MRI NeuroImage 1998, 7: s756. DOI: 10.1016/s1053-8119(18)31589-1.
  • Activation Response to Semantic and Syntactic Anomalies: an fMRI StudyConstable R, Ni W, Mencl E, Pugh K, Fulbright R, Shaywitz S, Shaywitz B, Gore J, Shankweiler D. Activation Response to Semantic and Syntactic Anomalies: an fMRI Study NeuroImage 1998, 7: s188. DOI: 10.1016/s1053-8119(18)31021-8.
  • Neuroanatomy of Reading and DyslexiaFulbright R, Shaywitz S, Shaywitz B, Pugh K, Skudlarski P, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Bronen R, Marchione K, Gore J. Neuroanatomy of Reading and Dyslexia Child And Adolescent Psychiatric Clinics Of North America 1997, 6: 431-446. DOI: 10.1016/s1056-4993(18)30312-2.
  • The Functional Organization of Brain for Reading and Reading Disability (DyslexiaShaywitz B, Shaywitz S, Pugh K, Skudlarski P, Fulbright R, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Bronen R, Marchione K, Lacadie C, Gore J. The Functional Organization of Brain for Reading and Reading Disability (Dyslexia The Neuroscientist 1996, 2: 245-255. DOI: 10.1177/107385849600200413.
  • Predicting reading performance from neuroimaging profiles: The cerebral basis of phonological effects in printed word identificationPugh K, Shaywitz B, Shaywitz S, Shankweiler D, Katz L, Fletcher J, Skudlarski P, Fulbright R, Constable R, Bronen R, Lacadie C, Gore J. Predicting reading performance from neuroimaging profiles: The cerebral basis of phonological effects in printed word identification NeuroImage 1996, 3: s455. DOI: 10.1016/s1053-8119(96)80457-5.
  • Functional magnetic resonance imaging of frontal cortex during performance of non-spatial associative memory tasksAdcock R, Constable R, Gore J, Goldman-Rakic P. Functional magnetic resonance imaging of frontal cortex during performance of non-spatial associative memory tasks NeuroImage 1996, 3: s526. DOI: 10.1016/s1053-8119(96)80528-3.
  • Limitations of ECG-gated SPECT for assessment of regional thickening: Experimental comparison with ECG-gated MRIGradel C, Staib L, Heller E, Constable R, Dione D, Liu Y, Wackers F, Sinusas A. Limitations of ECG-gated SPECT for assessment of regional thickening: Experimental comparison with ECG-gated MRI Journal Of The American College Of Cardiology 1996, 27: 241. DOI: 10.1016/s0735-1097(96)81838-9.
  • Dense nonrigid motion tracking from a sequence of velocity fieldsMeyer F, Constable R, Sinusas A, Duncan J. Dense nonrigid motion tracking from a sequence of velocity fields 2015 IEEE Conference On Computer Vision And Pattern Recognition (CVPR) 1996, 839-844. DOI: 10.1109/cvpr.1996.517169.
  • A Unified Framework to Assess Myocardial Function from 4D ImagesShi P, Robinson G, Chakraborty A, Staib L, Constable R, Sinusas A, Duncan J. A Unified Framework to Assess Myocardial Function from 4D Images 1995, 905: 327-337. DOI: 10.1007/978-3-540-49197-2_42.
  • A model-based integrated approach to track myocardial deformation using displacement and velocity constraintsShi P, Robinson G, Constable R, Sinusas A, Duncan J. A model-based integrated approach to track myocardial deformation using displacement and velocity constraints 1995, 687-692. DOI: 10.1109/iccv.1995.466872.
  • A recursive filter for phase velocity assisted shape-based tracking of cardiac non-rigid motionJ.C. I, Meyer F, Constable R, Nehorai A, Duncan J. A recursive filter for phase velocity assisted shape-based tracking of cardiac non-rigid motion 1995, 653-658. DOI: 10.1109/iccv.1995.466876.
  • Toward reliable, noninvasive measurement of myocardial function from 4D imagesDuncan J, Shi P, Amimi A, Constable R, Staib L, Dione D, Shi Q, Heller E, Singer M, Chakraborty A, Robinson G, Gore J, Sinusas A. Toward reliable, noninvasive measurement of myocardial function from 4D images Proceedings Of SPIE 1994, 2168: 149-161. DOI: 10.1117/12.174390.
  • Localization of semantic processing using functional magnetic resonance imagingShaywitz B, Pugh K, Constable R, Shaywitz S, Bronen R, Fulbright R, Shankweiler D, Katz L, Fletcher J, Skudlarski P, Gore J. Localization of semantic processing using functional magnetic resonance imaging Human Brain Mapping 1994, 2: 149-158. DOI: 10.1002/hbm.460020304.
  • Tracking tagged MR images with energy-minimizing deformable gridsShi P, Amini A, Constable R, Duncan J. Tracking tagged MR images with energy-minimizing deformable grids 1992, 133-134. DOI: 10.1109/nebc.1992.285985.
  • Energy-minimizing deformable grids for tracking tagged MR cardiac imagesAmini A, Shi P, Constable R, Johnson K, Duncan J, Gore J. Energy-minimizing deformable grids for tracking tagged MR cardiac images 1992, 651-654. DOI: 10.1109/cic.1992.269374.
  • Maximum Entropy Reconstruction in Magnetic Resonance ImagingConstable R, Henkelman R. Maximum Entropy Reconstruction in Magnetic Resonance Imaging 1989, 175-180. DOI: 10.1007/978-94-015-7860-8_15.

Clinical Trials

ConditionsStudy Title
COVID-19 OutpatientMagnetic Resonance Imaging Biomarkers: A tool to study central nervous system disease (MBAT)
Mental Health & Behavioral ResearchKetamine for Adolescent Suicidality
Mental Health & Behavioral Research; Alzheimer's DiseaseKetamine for the Treatment of Depression in Parkinson's Disease
Mental Health & Behavioral ResearchStudy of Brain Function Across the Lifespan
Child Development & AutismUnderstanding Neurodevelopment in Autism
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchBrain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Children's Health; Diseases of the Endocrine System; Immune SystemStudy to investigate adipocyte cell and lipid turnover in obese adolescents