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Hilary Blumberg, MD

John and Hope Furth Professor of Psychiatric Neuroscience and Professor of Psychiatry, and in the Child Study Center and of Radiology and Biomedical Imaging; Director, Mood Disorders Research Program

Research & Publications
Biography
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Research Summary

A focus of Dr. Blumberg's laboratory is the use of brain scanning techniques to elucidate the differences in brain circuitry that underlie mood disorders, and how these differences develop in children and adolescence and change over the lifespan into later life. The goal of the research is identify causes of the disorders to design improved treatments and preventive strategies to decrease the suffering and high risk of suicide associated with the disorders.

The lab is working intensively on genetic and environmental factors that may contribute to the brain differences and that may point to new prevention and treatment strategies. Brain scanning techniques used in this work include structural magnetic resonance imaging (MRI) to study the size and shape of brain structures (including cutting edge new methods with 7 Tesla MRI scanning), functional magnetic resonance imaging (fMRI) to study how the parts of the brain function individually and as part of brain circuits, and diffusion tensor imaging (DTI) to study the connections between brain structures.

Current research of the program includes study of a talk therapy to provide individuals with healthy strategies they can use to better regulate their emotions, BE-SMART (Brain Emotion Circuitry Targeted Self-Monitoring and Regulation Therapy), largely delivered by telehealth and that includes digital technologies such as wearables and smartphones.

Specialized Terms: Adolescence; Bipolar Disorder; Brain; Depression; Suicide; Development; Diffusion Tensor Imaging; Emotion; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Mania; Manic Depressive Disorder; Neuropsychiatry; Neuroscience; Women

Extensive Research Description

Dr. Blumberg is the Director of The Yale Mood Disorders Research Program (MDRP). The MDRP is dedicated to understanding the science of mood disorders, including bipolar disorder and depression, related disorders and suicide risk. The MDRP brings together a multi-disciplinary group of scientists from across the Yale campus in a highly collaborative research effort. The scientists use a wide variety of scientific methods to study how genetic and environmental factors affect the brain and influence the expression of mood disorders across the lifespan. Goals of the MDRP include the identification of biological markers for mood and related disorders and discovery of new treatment strategies. It is hoped that these research efforts will lead to new and improved methods for early detection and treatment, and prevention, of suffering and suicide risk of the disorders.

Current studies include:

MRI Brain Scanning Studies of Adolescents and Adults with Bipolar Disorder and Depression
MRI Brain Scanning Studies of Healthy Adolescents and Adults
MRI Brain Scanning Studies of Youths At-Risk for Bipolar Disorder
MRI Brain Scanning Studies of Adults ages 40-79 years with Bipolar Disorder or without psychiatric disorders
Study of a non-medication psychobehavioral treatment "BE-SMART" to provide individuals healthy skills they can use to improve their emotion regulation, decrease symptoms of bipolar disorder and depression and reduce their suicide risk.

Coauthors

Research Interests

Adolescent Psychiatry; Bipolar Disorder; Depression; Magnetic Resonance Imaging; Psychiatry; Suicide; Mood Disorders; Diffusion Tensor Imaging; Neuropsychiatry

Research Image

Brain Differences in Adolescents and Young Adults with Bipolar Disorder with Past Suicide Attempts

These images, from Johnston et al, American Journal of Psychiatry, 2017, display regions of the brain important in emotional regulation where adolescents and young adults with bipolar disorder who made suicide attempts showed decreases, compared to adolescents and young adults with bipolar disorder who did not make attempts. The top left image shows a region of decreased gray matter in ventral prefrontal cortex, the top right image shows a region of decreased functioning in ventral prefrontal cortex and the lower image shows regions of decreases in the structural integrity of white matter in connections from the ventral prefrontal cortex.

Selected Publications

Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes.Sankar A, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes. Psychological Medicine 2023, 1-10. PMID: 36891769, DOI: 10.1017/s003329172300003x.
Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD groupLavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group Bipolar Disorders 2023 PMID: 36843436, DOI: 10.1111/bdi.13312.
Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorderDauvermann M, Schmaal L, Colic L, van Velzen L, Bellow S, Ford T, Suckling J, Goodyer I, Consortium I, Blumberg H, van Harmelen A. Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder Journal Of Affective Disorders 2022, 325: 93-101. PMID: 36584707, DOI: 10.1016/j.jad.2022.12.087.
Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volumeVilla L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.
Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) projectBeunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.
Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disordersColic L, Villa L, Dauvermann M, Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Quatrano S, Spencer L, Constable R, Suckling J, Goodyer I, Schmaal L, Harmelen A, Blumberg H. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders JCPP Advances 2022, 2 DOI: 10.1002/jcv2.12118.
Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disordersColic L, Villa L, Dauvermann M, Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Quatrano S, Spencer L, Constable R, Suckling J, Goodyer I, Schmaal L, Harmelen A, Blumberg H. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders JCPP Advances 2022, 2 PMID: 36817186, PMCID: PMC9937714, DOI: 10.1002/jcv2.12118.
Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive DisorderHolmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.
Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adultsLavin P, Buck G, Almeida O, Su C, Eyler L, Dols A, Blumberg H, Forester B, Forlenza O, Gildengers A, Mulsant B, Tsai S, Vieta E, Schouws S, Briggs F, Sutherland A, Sarna K, Yala J, Orhan M, Korten N, Sajatovic M, Rej S, Investigators G. Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults International Journal Of Geriatric Psychiatry 2022, 37 PMID: 36317317, DOI: 10.1002/gps.5833.
Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorderHolmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 DOI: 10.1016/j.biopsych.2022.10.018.
A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adultsGoldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortiumvan Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.
Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorderColic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.
Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patientsDhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.
Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorderForlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.
Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioningOrhan M, Millett C, Klaus F, Blumberg HP, Briggs F, Chung KH, Korten N, McManus K, van Oppen P, Patrick RE, Sarna K, Sutherland A, Tsai SY, Villa LM, Yala J, Sajatovic M, Burdick KE, Eyler L, Dols A, consortium T. Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning Journal Of Affective Disorders 2022, 314: 44-49. PMID: 35803392, DOI: 10.1016/j.jad.2022.06.074.
Non-suicidal Self-injurious Thoughts and Behaviors Among Adolescent InpatientsMillon EM, Alqueza KL, Kamath RA, Marsh R, Pagliaccio D, Blumberg HP, Stewart JG, Auerbach RP. Non-suicidal Self-injurious Thoughts and Behaviors Among Adolescent Inpatients Child Psychiatry & Human Development 2022, 1-12. PMID: 35727385, PMCID: PMC9782727, DOI: 10.1007/s10578-022-01380-1.
Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.
Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by ActigraphyPanchal P, de Queiroz Campos G, Goldman DA, Auerbach RP, Merikangas KR, Swartz HA, Sankar A, Blumberg HP. Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy Frontiers In Psychiatry 2022, 13: 780726. PMID: 35677875, PMCID: PMC9167949, DOI: 10.3389/fpsyt.2022.780726.
A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar DisorderGoldman D, Sankar A, Colic L, Villa L, Kim J, Pittman B, Constable R, Scheinost D, Blumberg H. A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder Biological Psychiatry 2022, 91: s38-s39. DOI: 10.1016/j.biopsych.2022.02.114.
P276. Estradiol Effects on an Emotional Interference Task in Adolescents With Current and Remitted Major DepressionSullivan A, Chung Y, Novotny S, Epperson C, Kober H, Gross J, Phillips M, Blumberg H, Pearlson G, Stevens M. P276. Estradiol Effects on an Emotional Interference Task in Adolescents With Current and Remitted Major Depression Biological Psychiatry 2022, 91: s199. DOI: 10.1016/j.biopsych.2022.02.512.
P681. Estradiol Effects on Amygdala Activity During Emotion Regulation in Adolescent GirlsBarratt S, Novotny S, Chung Y, Kober H, Epperson C, Phillips M, Ochsner K, Gross J, Blumberg H, Pearlson G, Stevens M. P681. Estradiol Effects on Amygdala Activity During Emotion Regulation in Adolescent Girls Biological Psychiatry 2022, 91: s366. DOI: 10.1016/j.biopsych.2022.02.918.
P193. Right Lateral Amygdala Nucleus Volume in Adolescents and Young Adults With Bipolar Disorder Assessed With High Field Magnetic Resonance ImagingYe J, Fan S, Coman D, Kolosowska N, Goldman D, Spencer L, Qiu M, Dhaher R, Sankar A, Colic L, Mason G, Rothman D, Fudge J, Berretta S, Blumberg H. P193. Right Lateral Amygdala Nucleus Volume in Adolescents and Young Adults With Bipolar Disorder Assessed With High Field Magnetic Resonance Imaging Biological Psychiatry 2022, 91: s165. DOI: 10.1016/j.biopsych.2022.02.427.
Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD)Eyler LT, Briggs FBS, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant BH, Schouws S, Paans NPG, Strejilevich S, Sutherland A, Tsai S, Sajatovic M. Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) American Journal Of Geriatric Psychiatry 2022, 30: 1096-1107. PMID: 35637088, PMCID: PMC10280310, DOI: 10.1016/j.jagp.2022.03.007.
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborativeBurdick KE, Millett CE, Yocum AK, Altimus CM, Andreassen OA, Aubin V, Belzeaux R, Berk M, Biernacka JM, Blumberg H, Cleare AJ, Diaz‐Byrd C, Dubertret C, Etain B, Eyler LT, Forester BP, Fullerton JM, Frye MA, Gard S, Godin O, Haffen E, Klaus F, Lagerberg TV, Leboyer M, Martinez‐Aran A, McElroy S, Mitchell PB, Olie E, Olorunfemi P, Passerieux C, Peters AT, Pham DL, Polosan M, Potter JR, Sajatovic M, Samalin L, Schwan R, Shanahan M, Solé B, Strawbridge R, Stuart AL, Torres I, Ueland T, Vieta E, Williams LJ, Wrobel AL, Yatham LN, Young AH, Nierenberg AA, McInnis MG. Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative Bipolar Disorders 2022, 24: 709-719. PMID: 35322518, PMCID: PMC9500115, DOI: 10.1111/bdi.13208.
Illness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) ProjectSajatovic M, Lavin P, Blumberg H, Eyler L. Illness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) Project American Journal Of Geriatric Psychiatry 2022, 30: s8-s9. DOI: 10.1016/j.jagp.2022.01.263.
Toward low‐risk approaches to prevent bipolar disorder in at‐risk youthGoldman DA, Blumberg HP. Toward low‐risk approaches to prevent bipolar disorder in at‐risk youth Bipolar Disorders 2022, 24: 322-323. PMID: 35181984, PMCID: PMC9167252, DOI: 10.1111/bdi.13194.
Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry featuresDrachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.
Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorderSankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.
Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessmentMontejo L, Torrent C, Jiménez E, Martínez‐Arán A, Blumberg HP, Burdick KE, Chen P, Dols A, Eyler LT, Forester BP, Gatchel JR, Gildengers A, Kessing LV, Miskowiak KW, Olagunju AT, Patrick RE, Schouws S, Radua J, del M. Bonnín C, Vieta E, Force I. Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment Bipolar Disorders 2022, 24: 115-136. PMID: 34978124, DOI: 10.1111/bdi.13175.
Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A ReviewRajashekar N, Blumberg HP, Villa LM. Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review Journal Of Psychiatry And Brain Science 2022, 7: e220006. PMID: 36092855, PMCID: PMC9453888, DOI: 10.20900/jpbs.20220006.
Brain structure associated with future suicide thoughts and behaviors in female adolescents with mood disordersColic L, Villa L, Dauvermann M, van Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Schmaal L, van Harmelen A, Blumberg H. Brain structure associated with future suicide thoughts and behaviors in female adolescents with mood disorders Neuroscience Applied 2022, 1: 100781. DOI: 10.1016/j.nsa.2022.100781.
PHYSICAL HEALTH BURDEN AMONG OLDER MEN AND WOMEN WITH BIPOLAR DISORDER: RESULTS FROM THE GAGE-BD COLLABORATIONAlmeida OP, Dols A, Blanken MAJT, Rej S, Blumberg HP, Villa L, Forester BP, Forlenza OV, Gildengers A, Vieta E, Jimenez E, Mulsant B, Schouws S, Tsai S, Korten NCM, Sutherland A, Briggs FBS, Flicker L, Eyler LT, Sajatovic M. PHYSICAL HEALTH BURDEN AMONG OLDER MEN AND WOMEN WITH BIPOLAR DISORDER: RESULTS FROM THE GAGE-BD COLLABORATION American Journal Of Geriatric Psychiatry 2021, 30: 727-732. PMID: 34980553, DOI: 10.1016/j.jagp.2021.12.006.
P.0415 Meta-analysis of cognitive performance in older adults with bipolar disordersMontejo L, Torrent C, Jiménez E, Martínez-Arán A, Bonnín C, Vieta E, Blumberg H, Burdick K, Chen P, Dols A, Eyler L, Forester B, Gatchel J, Gildengers A, Kessing L, Miskowiak K, Olagunju A, Patrick R, Schouws S, Radua J. P.0415 Meta-analysis of cognitive performance in older adults with bipolar disorders European Neuropsychopharmacology 2021, 53: s301-s302. DOI: 10.1016/j.euroneuro.2021.10.388.
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorderGoldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.
Bipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database projectSajatovic M, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant B, Schouws S, Paans N, Strejilevich S, Sutherland A, Tsai S, Wilson B, Eyler LT. Bipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project Bipolar Disorders 2021, 24: 195-206. PMID: 34314549, PMCID: PMC8792096, DOI: 10.1111/bdi.13119.
Telehealth Social Rhythm Therapy to Reduce Mood Symptoms and Suicide Risk Among Adolescents and Young Adults With Bipolar DisorderSankar A, Panchal P, Goldman DA, Colic L, Villa LM, Kim JA, Lebowitz ER, Carrubba E, Lecza B, Silverman WK, Swartz HA, Blumberg HP. Telehealth Social Rhythm Therapy to Reduce Mood Symptoms and Suicide Risk Among Adolescents and Young Adults With Bipolar Disorder American Journal Of Psychotherapy 2021, 74: 172-177. PMID: 34293928, PMCID: PMC9588254, DOI: 10.1176/appi.psychotherapy.20210011.
A Graph Theoretical Connectome Measure to Assess Whole Brain Functional Connectivity Disturbances Associated With Suicide Attempts in Bipolar DisorderSankar A, Scheinost D, Goldman D, Drachman R, Colic L, Villa L, Kim J, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie C, Oquendo M, Constable R, Blumberg H. A Graph Theoretical Connectome Measure to Assess Whole Brain Functional Connectivity Disturbances Associated With Suicide Attempts in Bipolar Disorder Biological Psychiatry 2021, 89: s296. DOI: 10.1016/j.biopsych.2021.02.737.
Brain Structure Circuitry Associated With the Development of Suicide Thoughts and Behaviors in Adolescents and Young Adults With Mood DisordersColic L, Villa L, Goldman D, Panchal P, Sankar A, Blumberg H. Brain Structure Circuitry Associated With the Development of Suicide Thoughts and Behaviors in Adolescents and Young Adults With Mood Disorders Biological Psychiatry 2021, 89: s21-s22. DOI: 10.1016/j.biopsych.2021.02.073.
Age-Related Brain Structure Differences, by Age of Onset, in Older Adults with Bipolar DisorderVilla L, Colic L, Sankar A, Goldman D, Lessing B, Alexopoulos G, van Dyck C, Blumberg H. Age-Related Brain Structure Differences, by Age of Onset, in Older Adults with Bipolar Disorder American Journal Of Geriatric Psychiatry 2021, 29: s26. DOI: 10.1016/j.jagp.2021.01.019.
Changing gears in the treatment of bipolar disorder through integrated use of electronic devicesPanchal P, Kim JA, Sankar A, Goldman D, Villa LM, Millard H, Carrubba E, Lecza B, Merikangas KR, Silverman WK, Swartz HA, Blumberg HP. Changing gears in the treatment of bipolar disorder through integrated use of electronic devices Bipolar Disorders 2021, 23: 418-419. PMID: 33638233, PMCID: PMC9587895, DOI: 10.1111/bdi.13065.
7.3 EFFECTS OF A TARGETED PSYCHOBEHAVIORAL INTERVENTION ON EMOTION REGULATION, MOOD, SUICIDE RISK, AND BRAIN CIRCUITRY IN ADOLESCENTS AND YOUNG ADULTS WITH BIPOLAR DISORDERKim J, Sankar A, Goldman D, Colic L, Spencer L, Lecza B, Silverman W, Swartz H, Blumberg H. 7.3 EFFECTS OF A TARGETED PSYCHOBEHAVIORAL INTERVENTION ON EMOTION REGULATION, MOOD, SUICIDE RISK, AND BRAIN CIRCUITRY IN ADOLESCENTS AND YOUNG ADULTS WITH BIPOLAR DISORDER Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: s168. DOI: 10.1016/j.jaac.2020.08.124.
Imaging suicidal thoughts and behavior: the promise of computational modelsvan Harmelen AL, Schmaal L, Blumberg HP. Imaging suicidal thoughts and behavior: the promise of computational models Neuropsychopharmacology 2020, 46: 219-220. PMID: 32895454, PMCID: PMC7688630, DOI: 10.1038/s41386-020-00841-2.
What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working GroupChing CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, Zwarte S, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro‐de‐Souza M, Tronchin G, Haren N, Vieta E, Walter H, Zeng L, Alda M, Almeida J, Alnæs D, Alonso‐Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, Bonnin C, Brambilla P, Canales‐Rodríguez E, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz‐Zuluaga A, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives‐Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López‐Jaramillo C, Machado‐Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda‐Zapata J, Poletti S, Polosan M, Pomarol‐Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu M, Yatham LN, Zarate CA, Thompson PM, Andreassen OA, Group E. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group Human Brain Mapping 2020, 43: 56-82. PMID: 32725849, PMCID: PMC8675426, DOI: 10.1002/hbm.25098.
Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorderSankar A, Purves K, Colic L, Lippard ETC, Millard H, Fan S, Spencer L, Wang F, Pittman B, Constable RT, Gross JJ, Blumberg HP. Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder Bipolar Disorders 2020, 23: 152-164. PMID: 32521570, PMCID: PMC7790437, DOI: 10.1111/bdi.12954.
Mood State Differences in Intrinsic Connectivity Distribution of Adolescents and Young Adults With Bipolar DisorderGoldman D, Sankar A, Colic L, Spencer L, Lacadie C, Scheinost D, Constable R, Blumberg H. Mood State Differences in Intrinsic Connectivity Distribution of Adolescents and Young Adults With Bipolar Disorder Biological Psychiatry 2020, 87: s416-s417. DOI: 10.1016/j.biopsych.2020.02.1063.
Targeting Emotion Regulation Circuitry With a Psychobehavioral Intervention to Reduce Hopelessness in Bipolar DisorderSankar A, Goldman D, Colic L, Kim J, Spencer L, Lecza B, Carrubba E, Quatrano S, Silverman W, Swartz H, Blumberg H. Targeting Emotion Regulation Circuitry With a Psychobehavioral Intervention to Reduce Hopelessness in Bipolar Disorder Biological Psychiatry 2020, 87: s116. DOI: 10.1016/j.biopsych.2020.02.318.
Brain Circuitry Targets to Interrupt the Development of Suicide Thoughts and BehaviorsColic L, Lippard E, Goldman D, Sankar A, Blumberg H. Brain Circuitry Targets to Interrupt the Development of Suicide Thoughts and Behaviors Biological Psychiatry 2020, 87: s23. DOI: 10.1016/j.biopsych.2020.02.084.
Self-Reported Child Maltreatment, History of Suicide Attempts and Surface Area in Adults With Bipolar DisorderColic L, Sankar A, Clark A, Rathi D, Goldman D, Lippard E, Blumberg H. Self-Reported Child Maltreatment, History of Suicide Attempts and Surface Area in Adults With Bipolar Disorder Biological Psychiatry 2020, 87: s441. DOI: 10.1016/j.biopsych.2020.02.1124.
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studiesSchmaal L, van Harmelen AL, Chatzi V, Lippard ETC, Toenders YJ, Averill LA, Mazure CM, Blumberg HP. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies Molecular Psychiatry 2019, 25: 408-427. PMID: 31787757, PMCID: PMC6974434, DOI: 10.1038/s41380-019-0587-x.
A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulationChung YS, Poppe A, Novotny S, Epperson CN, Kober H, Granger DA, Blumberg HP, Ochsner K, Gross JJ, Pearlson G, Stevens MC. A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation Psychoneuroendocrinology 2019, 109: 104398. PMID: 31394491, PMCID: PMC6842698, DOI: 10.1016/j.psyneuen.2019.104398.
Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently neededVan Harmelen A, Schmaal L, Blumberg HP. Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed Journal Of Affective Disorders 2019, 251: 39-41. PMID: 30901600, PMCID: PMC6953378, DOI: 10.1016/j.jad.2019.03.054.
Increased Anterior Cingulate and Caudate Activity in Bipolar ManiaBlumberg H, Stem E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased Anterior Cingulate and Caudate Activity in Bipolar Mania 2019, 177-184. DOI: 10.4324/9781315054308-17.
THE USE OF MULTIMODAL MRI AND COMPUTATIONAL APPROACHES TO INFORM NOVEL INTERVENTIONS FOR AGING AND MOOD DISORDERS Session 102Gunning F, Blumberg H, Wang L, Victoria L. THE USE OF MULTIMODAL MRI AND COMPUTATIONAL APPROACHES TO INFORM NOVEL INTERVENTIONS FOR AGING AND MOOD DISORDERS Session 102 American Journal Of Geriatric Psychiatry 2019, 27: s4. DOI: 10.1016/j.jagp.2019.01.139.
Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disordersLippard ETC, Johnston JAY, Spencer L, Quatrano S, Fan S, Sankar A, Weathers J, Pittman B, Oquendo MA, Blumberg HP. Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders Journal Of Affective Disorders 2018, 245: 1139-1148. PMID: 30699858, PMCID: PMC6487887, DOI: 10.1016/j.jad.2018.11.097.
Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disordersFan S, Lippard ETC, Sankar A, Wallace A, Johnston JAY, Wang F, Pittman B, Spencer L, Oquendo MA, Blumberg HP. Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders Journal Of Affective Disorders 2018, 245: 1089-1097. PMID: 30699851, PMCID: PMC6903411, DOI: 10.1016/j.jad.2018.11.095.
206. Neuroimaging View of the Temporal Architecture of Bipolar DisorderLippard E, Fan S, Weathers J, Wang F, Blumberg H. 206. Neuroimaging View of the Temporal Architecture of Bipolar Disorder Biological Psychiatry 2018, 83: s83. DOI: 10.1016/j.biopsych.2018.02.225.
117. Neurodevelopment of Suicidal Behavior in Bipolar DisorderLippard E, Wang F, Oquendo M, Blumberg H. 117. Neurodevelopment of Suicidal Behavior in Bipolar Disorder Biological Psychiatry 2018, 83: s48. DOI: 10.1016/j.biopsych.2018.02.135.
F143. Commonalities and Distinctions in White Matter Integrity Associated With Suicide Behavior Between Adolescents and Young Adults With Bipolar Disorder and Major Depressive DisorderFan S, Cox B, Wallace A, Spencer L, Oquendo M, Blumberg H. F143. Commonalities and Distinctions in White Matter Integrity Associated With Suicide Behavior Between Adolescents and Young Adults With Bipolar Disorder and Major Depressive Disorder Biological Psychiatry 2018, 83: s293. DOI: 10.1016/j.biopsych.2018.02.757.
Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar DisorderWeathers J, Lippard ETC, Spencer L, Pittman B, Wang F, Blumberg HP. Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 57: 111-117. PMID: 29413143, PMCID: PMC5806147, DOI: 10.1016/j.jaac.2017.11.014.
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar DisorderJohnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.
Effects of ANK3 variation on gray and white matter in bipolar disorderLippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Effects of ANK3 variation on gray and white matter in bipolar disorder Molecular Psychiatry 2016, 22: 1345-1351. PMID: 27240527, PMCID: PMC5133179, DOI: 10.1038/mp.2016.76.
Anterior Cortical Development During Adolescence in Bipolar DisorderNajt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.
Neurobiology of Developing Bipolar DisorderRusso J, de Zwarte S, Blumberg H. Neurobiology of Developing Bipolar Disorder 2014, 243-281. DOI: 10.1093/med/9780199985357.003.0011.
Integrating Imaging and Genetic ResearchPerlis R, Blumberg H. Integrating Imaging and Genetic Research 2012, 239-252. DOI: 10.1093/med/9780199797608.003.0101.
Corticostriatal-Limbic Gray Matter Morphology in Adolescents With Self-reported Exposure to Childhood MaltreatmentEdmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP. Corticostriatal-Limbic Gray Matter Morphology in Adolescents With Self-reported Exposure to Childhood Maltreatment JAMA Pediatrics 2011, 165: 1069-1077. PMID: 22147775, PMCID: PMC3607102, DOI: 10.1001/archpediatrics.2011.565.
Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704CysSprooten E, Sussmann J, Moorhead T, Whalley H, Ffrench-Constant C, Blumberg H, Bastin M, Hall J, Lawrie S, McIntosh A. Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys Molecular Psychiatry 2011, 16: 685-685. DOI: 10.1038/mp.2011.69.
Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorderWang F, Kalmar JH, Womer FY, Edmiston EE, Chepenik LG, Chen R, Spencer L, Blumberg HP. Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder Brain 2011, 134: 2005-2012. PMID: 21666263, PMCID: PMC3122371, DOI: 10.1093/brain/awr124.
P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trialSaricicek A, Maloney K, Lorberg B, Muralidharan A, Ruf B, Blumberg H, Hu J, Pittman B, Sanacora G, Bhagwagar Z. P.2.e.029 Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo controlled trial European Neuropsychopharmacology 2009, 19: s465. DOI: 10.1016/s0924-977x(09)70728-x.
A Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) StudyKerestes R, Ladouceur C, Meda S, Blumberg H, Nathan P, Maloney K, Ruf B, Saricicek A, Hu J, Pearlson G, Bhagwagar Z, Phillips M. A Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) Study NeuroImage 2009, 47: s191. DOI: 10.1016/s1053-8119(09)72145-7.
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar DisorderWang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.
Cortico-limbic development in bipolar disorder: a neuroimaging viewKalmar J, Shah M, Blumberg H. Cortico-limbic development in bipolar disorder: a neuroimaging view 2009, 161-182. DOI: 10.1017/cbo9780511757402.014.
Neuroimaging of emotional brain circuitry in bipolar disorderWeder N, Chepenik L, Kalmar J, Blumberg H. Neuroimaging of emotional brain circuitry in bipolar disorder Current Psychosis And Therapeutics Reports 2006, 4: 159-166. DOI: 10.1007/bf02629390.
The role of the ventral prefrontal cortex in mood disordersFredericks C, Kalmar J, Blumberg H. The role of the ventral prefrontal cortex in mood disorders 2006, 545-578. DOI: 10.1093/acprof:oso/9780198565741.003.0021.
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional StudyBlumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar DisorderBlumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal CorticesBlumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.
Book Review: Advances in Brain ImagingBlumberg H. Book Review: Advances in Brain Imaging Clinical EEG And Neuroscience 2003, 34: v-v. DOI: 10.1177/155005940303400103.
Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depressionde Asis J, Stern E, Alexopoulos G, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig D. Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression American Journal Of Psychiatry 2001, 158: 1321-1323. PMID: 11481171, DOI: 10.1176/appi.ajp.158.8.1321.
Hippocampal and posterior association cortical hypoactivity associated with memory dysfunction in geriatric depressionDe Asis J, Stern E, Alexopoulos G, Pan H, Blumberg H, Wilfred V, Silbersweig D. Hippocampal and posterior association cortical hypoactivity associated with memory dysfunction in geriatric depression NeuroImage 2001, 13: 1040. DOI: 10.1016/s1053-8119(01)92373-0.
Increased anterior cingulate and caudate activity in bipolar maniaBlumberg H, Stern E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased anterior cingulate and caudate activity in bipolar mania Biological Psychiatry 2000, 48: 1045-1052. PMID: 11094137, DOI: 10.1016/s0006-3223(00)00962-8.
Rostral and Orbital Prefrontal Cortex Dysfunction in the Manic State of Bipolar DisorderBlumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, Emmerich S, Dhawan V, Eidelberg D, Kocsis JH, Silbersweig DA. Rostral and Orbital Prefrontal Cortex Dysfunction in the Manic State of Bipolar Disorder American Journal Of Psychiatry 1999, 156: 1986-1988. PMID: 10588416, DOI: 10.1176/ajp.156.12.1986.
DECREASED ORBITOFRONTAL ACTIVATION IN MANIA: AN H2150 PET ACTIVATION STUDYBlumberg H, Silbersweig D, Martinez D, Ricketts S, de Asis J, White T, McBride A, Kemperman I, Isenberg N, Emmerich S, Epstein J, Eidelberg D, Kocsis J, Stern E. DECREASED ORBITOFRONTAL ACTIVATION IN MANIA: AN H2150 PET ACTIVATION STUDY NeuroImage 1998, 7: s896. DOI: 10.1016/s1053-8119(18)31729-4.
Paranoia, Perceiving Threat where there is None: An H2 150 Pet Study of Mesotemporal Function in SchizophreniaIsenberg N, Stern E, Smith T, Emmerich S, Malavade K, Beattie B, Blumberg H, Epstein J, Bride A, Silbersweig D. Paranoia, Perceiving Threat where there is None: An H2 150 Pet Study of Mesotemporal Function in Schizophrenia NeuroImage 1998, 7: s95. DOI: 10.1016/s1053-8119(18)30928-5.
91. Increased activation of cingulate and association cortices in the manic stateBlumberg H, Silbersweig D, Martinez D, Ricketts S, de Asis J, McBride A, White T, Eidelberg D, Isenberg N, Kemperman I, Emmerich S, Epstein J, Kocsis J, Stern E. 91. Increased activation of cingulate and association cortices in the manic state Biological Psychiatry 1998, 43: s28. DOI: 10.1016/s0006-3223(98)90539-x.
The Anatomy of a Consultation: A teaching methodViederman M, Blumberg H. The Anatomy of a Consultation: A teaching method General Hospital Psychiatry 1993, 15: 183-192. PMID: 8325501, DOI: 10.1016/0163-8343(93)90123-6.
General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degenerationGandy S, Grebb J, Rosen N, Albert K, Devinsky O, Blumberg H, Anderson N, Cedarbaum J, Porter R, Sedvall G, Posner J, Greengard P. General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration Annals Of Neurology 1990, 28: 829-833. PMID: 2285268, DOI: 10.1002/ana.410280616.

Clinical Trials

Conditions	Study Title
Mental Health & Behavioral Research	Impact of Reward and Frustration on Early Attention: Associations with Irritability in Young Adults
Diseases of the Nervous System; Mental Health & Behavioral Research	Examination of Glutamate and mGluR5 in Psychiatric Disorders
	Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral Research	Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Mental Health & Behavioral Research	Imaging mGluR5 and synaptic density in psychiatric disorders
	Reducing Suicide Risk in Adolescents and Young Adults with Bipolar Disorder and Depression via a Psychobehavioral Intervention

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