Eyiyemisi Damisah, MD
Assistant Professor of Neurosurgery; Assistant Professor, Neuroscience
Research & Publications
Biography
News
Research Summary
my lab is interested in identifying central hubs that modulate large scale brain networks and are critical for various arousal states (e.g., sleep, selective attention, hyper-arousal)
Extensive Research Description
We use methodologies such as single and multi-unit neuron recordings, intracranial electroencephalogram, closed loop recording and stimulating devices such as DBS, RNS, measures of the autonomic nervous system (heart rate, pupillometry). This invasive human electrophysiology-centric approach is combined with behavioral tasks, naturalistic behaviors, and computational modeling to ask fundamental questions related to identifying:
1. central hubs that modulate large scale brain networks and are critical for various arousal states (e.g., deep sleep, selective attention, hyperarousal)
2. the neural correlates of interoceptive feedback during periods of heightened states of arousal
3. neural correlates of emotional valence in the humans
We also have projects aimed at the understating and developing potential therapies for neurodegenerative and neuropsychiatric pathologies. In collaboration with Dr. Alfred Kaye, we record intracranial EEG in human epilepsy patients during task-based threat avoidance behaviors. These projects involve computational modeling of behavior, time series analysis of human electrophysiology/or brain tissue analysis after resective brain surgery. Our goal is to define circuit-level signatures of threat processing across the continuum of threat proximity.
Coauthors
Research Interests
Alzheimer Disease; Anxiety; Epilepsy; Memory Disorders; Psychological Distress
Research Images
Selected Publications
- Intracranial Entrainment Reveals Statistical Learning across Levels of AbstractionSherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 35: 1312-1328. PMID: 37262357, DOI: 10.1162/jocn_a_02012.
- Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe EpilepsyKhoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.
- Recent advances in epilepsy surgeryMedina-Pizarro M, Spencer D, Damisah E. Recent advances in epilepsy surgery. Current Opinion In Neurology 2023, 36: 95-101. PMID: 36762633, DOI: 10.1097/wco.0000000000001134.
- Transfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case ReportLamsam L, Brigido M, Sivaraju A, Hirsch L, Spencer D, Chiang V, Damisah E. Transfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report. Operative Neurosurgery 2023, 24: e381-e384. PMID: 36715982, PMCID: PMC10158899, DOI: 10.1227/ons.0000000000000576.
- Shared and distinct representations of visual regularities across levels of abstractionSherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Shared and distinct representations of visual regularities across levels of abstraction. Journal Of Vision 2022, 22: 3410. DOI: 10.1167/jov.22.14.3410.
- Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex.Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.
- Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidationGraves KN, Sherman BE, Huberdeau D, Damisah E, Quraishi IH, Turk-Browne NB. Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation. Neuropsychologia 2022, 174: 108341. PMID: 35961387, PMCID: PMC9578695, DOI: 10.1016/j.neuropsychologia.2022.108341.
- Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory EpilepsySivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.
- P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in AnxietyAljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
- P142. Neural Correlates of Bodily Feedback During Spatial Threat AvoidanceShaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
- Optimizing the surgical management of MRI‐negative epilepsy in the neuromodulation eraMcGrath H, Mandel M, Sandhu MRS, Lamsam L, Adenu‐Mensah N, Farooque P, Spencer DD, Damisah EC. Optimizing the surgical management of MRI‐negative epilepsy in the neuromodulation era. Epilepsia Open 2022, 7: 151-159. PMID: 35038792, PMCID: PMC8886105, DOI: 10.1002/epi4.12578.
- Dynamics of category-level statistical learning from intracranial recordings in visual cortexSherman B, Graves K, Huberdeau D, Benjamin C, Quraishi I, Damisah E, Turk-Browne N. Dynamics of category-level statistical learning from intracranial recordings in visual cortex. Journal Of Vision 2021, 21: 2255. DOI: 10.1167/jov.21.9.2255.
- Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.Sandhu MRS, Mandel M, McGrath H, Lamsam L, Farooque P, Bronen RA, Spencer DD, Damisah EC. Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles. Journal Of Neurosurgery 2021, 136: 709-716. PMID: 34507290, DOI: 10.3171/2021.3.jns21133.
- Imaging of Neuromodulation and Surgical Interventions for EpilepsyAdin ME, Spencer DD, Damisah E, Herlopian A, Gerrard JL, Bronen RA. Imaging of Neuromodulation and Surgical Interventions for Epilepsy. American Journal Of Neuroradiology 2021, 42: 1742-1750. PMID: 34353787, PMCID: PMC8562735, DOI: 10.3174/ajnr.a7222.
- Gerstmann Syndrome Deconstructed by Cortical StimulationVaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.
- Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brainOng C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, DOI: 10.1111/epi.16920.
- Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal CortexMcClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
- Depth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative VideoMandel M, Lamsam L, Farooque P, Spencer D, Damisah E. Depth Electrode Guided Anterior Insulectomy: 2-Dimensional Operative Video. Operative Neurosurgery 2021, 21: e121-e121. PMID: 33885821, PMCID: PMC8493659, DOI: 10.1093/ons/opab112.
- Imaging and optogenetic modulation of vascular mural cells in the live brainTong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Imaging and optogenetic modulation of vascular mural cells in the live brain. Nature Protocols 2020, 16: 472-496. PMID: 33299155, DOI: 10.1038/s41596-020-00425-w.
- Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe SeizuresHong CS, Gorrepati R, Kundishora AJ, Elsamadicy AA, Peter PR, Damisah EC, Manes RP, Omay SB. Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures. Frontiers In Surgery 2020, 7: 598138. PMID: 33335912, PMCID: PMC7736041, DOI: 10.3389/fsurg.2020.598138.
- Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivoDamisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Science Advances 2020, 6: eaba3239. PMID: 32637606, PMCID: PMC7319765, DOI: 10.1126/sciadv.aba3239.
- Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targetsKarimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nature Reviews Neurology 2020, 16: 285-296. PMID: 32152460, PMCID: PMC7375440, DOI: 10.1038/s41582-020-0321-y.
- TREM2: Modulator of Lipid Metabolism in MicrogliaDamisah EC, Rai A, Grutzendler J. TREM2: Modulator of Lipid Metabolism in Microglia. Neuron 2020, 105: 759-761. PMID: 32135085, DOI: 10.1016/j.neuron.2020.02.008.
- Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory studyLu AY, Damisah EC, Winkler EA, Grant RA, Eid T, Bulsara KR. Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study. British Journal Of Neurosurgery 2018, 32: 637-641. PMID: 30585503, DOI: 10.1080/02688697.2018.1519107.
- (Invited) Conjoint Measurement of Brain Electrophysiology and NeurochemistryZaveri H, Ganesh N, Goncharova I, Damisah E, Ong C, Perez E, Staib L, Hirsch L, Petroff O, Spencer D, Eid T. (Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry. ECS Meeting Abstracts 2017, MA2017-02: 2329-2329. DOI: 10.1149/ma2017-02/55/2329.
- Targeted two-photon chemical apoptotic ablation of defined cell types in vivoHill RA, Damisah EC, Chen F, Kwan AC, Grutzendler J. Targeted two-photon chemical apoptotic ablation of defined cell types in vivo. Nature Communications 2017, 8: 15837. PMID: 28621306, PMCID: PMC5501159, DOI: 10.1038/ncomms15837.
- A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imagingDamisah EC, Hill RA, Tong L, Murray KN, Grutzendler J. A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging. Nature Neuroscience 2017, 20: 1023-1032. PMID: 28504673, PMCID: PMC5550770, DOI: 10.1038/nn.4564.
- 5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsyDhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, Gruenbaum BF, Eid T. 5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiology Of Disease 2014, 67: 18-23. PMID: 24632421, PMCID: PMC4035438, DOI: 10.1016/j.nbd.2014.03.006.
- Intra-Arterial Treatment of Acute Ischemic Stroke: The Continued EvolutionLu AY, Ansari SA, Nyström KV, Damisah EC, Amin HP, Matouk CC, Pashankar RD, Bulsara KR. Intra-Arterial Treatment of Acute Ischemic Stroke: The Continued Evolution. Current Treatment Options In Cardiovascular Medicine 2014, 16: 281. PMID: 24398801, DOI: 10.1007/s11936-013-0281-2.
- 139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related EpilepsyOng C, Damisah E, Haldeman C, Eid T, Spencer D. 139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related Epilepsy. Neurosurgery 2013, 60: 166. DOI: 10.1227/01.neu.0000432730.18532.a2.
- Linking of Bone Morphogenetic Protein‐2 To Resorbable Fracture Plates for Enhancing Bone HealingShibuya TY, Wadhwa A, Nguyen KH, Panossian AM, Kim S, Wong H, Feinberg S, Damisah EC, Camilon PR, Bang H. Linking of Bone Morphogenetic Protein‐2 To Resorbable Fracture Plates for Enhancing Bone Healing. The Laryngoscope 2005, 115: 2232-2237. PMID: 16369172, DOI: 10.1097/01.mlg.0000183692.27532.5b.