Imran Quraishi, MD, PhD

• Adithya Sivaraju
• Christopher Benjamin
• Eyiyemisi Damisah
• Hal Blumenfeld
• Lawrence Hirsch
• Leonard Kaczmarek
• Michael Schwartz
• Pramod Mistry

Biomedical Engineering; Electric Stimulation; Electroencephalography; Epilepsy; Ion Channels; Neurosciences; Seizures; Computational Biology; Channelopathies; Cognitive Neuroscience

• Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction.Sherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction. Journal Of Cognitive Neuroscience 2023, 1-17. PMID: 37262357, DOI: 10.1162/jocn_a_02012.
• Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentialsGovindaraju A, Quraishi I, Lysakowski A, Eatock R, Raphael R. Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2207466120. PMID: 36595693, PMCID: PMC9926171, DOI: 10.1073/pnas.2207466120.
• Shared and distinct representations of visual regularities across levels of abstractionSherman B, Aljishi A, Graves K, Quraishi I, Sivaraju A, Damisah E, Turk-Browne N. Shared and distinct representations of visual regularities across levels of abstraction. Journal Of Vision 2022, 22: 3410. DOI: 10.1167/jov.22.14.3410.
• Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex.Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.
• Electronic seizure diaries for clinical care and researchGray TE, Hirsch LJ, Quraishi IH. Electronic seizure diaries for clinical care and research. Epileptic Disorders 2022, 24: 803-811. PMID: 35811431, DOI: 10.1684/epd.2022.1451.
• Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testingRamirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.
• Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidationGraves KN, Sherman BE, Huberdeau D, Damisah E, Quraishi IH, Turk-Browne NB. Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation. Neuropsychologia 2022, 174: 108341. PMID: 35961387, PMCID: PMC9578695, DOI: 10.1016/j.neuropsychologia.2022.108341.
• Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testingQuraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.
• Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortexSherman BE, Graves KN, Huberdeau DM, Quraishi IH, Damisah EC, Turk-Browne NB. Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortex. BioRxiv 2022.03.14.484293
• Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 miceZhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK. Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice. The FASEB Journal 2021, 35: e22053. PMID: 34820911, PMCID: PMC8630780, DOI: 10.1096/fj.202101356r.
• Dynamics of category-level statistical learning from intracranial recordings in visual cortexSherman B, Graves K, Huberdeau D, Benjamin C, Quraishi I, Damisah E, Turk-Browne N. Dynamics of category-level statistical learning from intracranial recordings in visual cortex. Journal Of Vision 2021, 21: 2255. DOI: 10.1167/jov.21.9.2255.
• Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure SyndromeQuraishi IH, Szekely AM, Shirali AC, Mistry PK, Hirsch LJ. Miglustat Therapy for SCARB2-Associated Action Myoclonus–Renal Failure Syndrome. Neurology Genetics 2021, 7: e614. PMID: 34337151, PMCID: PMC8320328, DOI: 10.1212/nxg.0000000000000614.
• Gerstmann Syndrome Deconstructed by Cortical Stimulation.Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.
• Patient‐detectable responsive neurostimulation as a seizure warning systemQuraishi IH, Hirsch LJ. Patient‐detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.
• Electrical cortical stimulation can impair production of the alphabet without impairing countingRojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Electrical cortical stimulation can impair production of the alphabet without impairing counting. Epilepsy & Behavior Reports 2021, 15: 100433. PMID: 33778464, PMCID: PMC7985277, DOI: 10.1016/j.ebr.2021.100433.
• Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidationGraves KN, Sherman BE, Huberdeau D, Damisah E, Quraishi IH, Turk-Browne NB. Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation. BioRxiv 2021.10.18.464818
• Low-voltage-activated K currents in vestibular hair cells and calyceal afferent terminals mediate nonquantal transmission by modulating electrical and K+ potentials in the synaptic cleftGovindaraju AC, Quraishi IH, Lysakowski A, Eatock RA, Raphael RM. Low-voltage-activated K currents in vestibular hair cells and calyceal afferent terminals mediate nonquantal transmission by modulating electrical and K+ potentials in the synaptic cleft. BioRxiv 2021.11.18.469197v1
• Responsive NeurostimulationGummadavelli A, Quraishi I, Gerrard J. Responsive Neurostimulation. 2020, 145-173. DOI: 10.1007/978-3-030-34906-6_12.
• Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channelsQuraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.
• Biophysical Model of the Vestibular Hair Cell CALYX SynapseGovindaraju A, Quraishi I, Lysakowski A, Eatock R, Raphael R. Biophysical Model of the Vestibular Hair Cell CALYX Synapse. Biophysical Journal 2020, 118: 28a. DOI: 10.1016/j.bpj.2019.11.333.
• Responsive NeurostimulationGummadavelli A, Quraishi IH, Gerrard JL. Responsive Neurostimulation. In: Stereotactic and Functional Neurosurgery, Nader Pouratian and Sameer Sheth (Eds). 2020. Springer, Cham
• Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugsQuraishi IH, Mercier MR, Skarpaas TL, Hirsch LJ. Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugs. Epilepsia 2019, 61: 138-148. PMID: 31849045, PMCID: PMC7003822, DOI: 10.1111/epi.16412.
• An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa CurrentsQuraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. Journal Of Neuroscience 2019, 39: 7438-7449. PMID: 31350261, PMCID: PMC6759030, DOI: 10.1523/jneurosci.1628-18.2019.
• T02. Impairment of consciousness induced by electrical cortical stimulation: Under-reported phenomenon or a disease-specific condition?Quraishi I, Benjamin C, Spencer D, Blumenfeld H, Alkawadri R. T02. Impairment of consciousness induced by electrical cortical stimulation: Under-reported phenomenon or a disease-specific condition? Clinical Neurophysiology 2018, 129: e1-e2. DOI: 10.1016/j.clinph.2018.04.003.
• T08. Early changes in responsive neurostimulator detection rates after introduction: Of anti-seizure drugs predict efficacyMercier M, Hirsch L, Duckrow R, Quraishi I. T08. Early changes in responsive neurostimulator detection rates after introduction: Of anti-seizure drugs predict efficacy. Clinical Neurophysiology 2018, 129: e4. DOI: 10.1016/j.clinph.2018.04.009.
• iPSC-Derived Neurons Harboring a Known Epilepsy Mutation Provide a ‘Disease-in-a-Dish’ Capability that Displays Established and Novel Epileptic PhenotypesMangan K, Quraishi I, Zhang Y, McLachlan M, Meline B, McMahon C, Enghofer E, Kannemeier C, Jones E, Kaczmarek L. iPSC-Derived Neurons Harboring a Known Epilepsy Mutation Provide a ‘Disease-in-a-Dish’ Capability that Displays Established and Novel Epileptic Phenotypes. Biophysical Journal 2018, 114: 487a. DOI: 10.1016/j.bpj.2017.11.2674.
• Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexityQuraishi IH, Benjamin CF, Spencer DD, Blumenfeld H, Alkawadri R. Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity. Epilepsy & Behavior Reports 2017, 8: 117-122. PMID: 29204347, PMCID: PMC5707211, DOI: 10.1016/j.ebcr.2017.09.006.
• Hypothermia associated with clobazam use in adult epilepsyGauthier AC, Quraishi IH, Mattson RH. Hypothermia associated with clobazam use in adult epilepsy. Epilepsy & Behavior Reports 2016, 5: 17-18. PMID: 26870662, PMCID: PMC4739151, DOI: 10.1016/j.ebcr.2016.01.002.
• Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual ChannelsKim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK. Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels. Cell Reports 2014, 9: 1661-1672. PMID: 25482562, PMCID: PMC4294418, DOI: 10.1016/j.celrep.2014.11.015.
• Generation of the Endocochlear Potential: A Biophysical ModelQuraishi IH, Raphael RM. Generation of the Endocochlear Potential: A Biophysical Model. Biophysical Journal 2008, 94: l64-l66. PMID: 18227126, PMCID: PMC2275700, DOI: 10.1529/biophysj.107.128082.
• Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cellsQuraishi IH, Raphael RM. Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells. American Journal Of Physiology - Cell Physiology 2006, 292: c591-c602. PMID: 17005601, DOI: 10.1152/ajpcell.00560.2005.
• Mathematical model of a marginal cell in the stria vascularisQuraishi IH, Raphael RM. Mathematical model of a marginal cell in the stria vascularis. In: Proceedings 5th International Symposium on Meniere's Disease and Inner Ear Homeostasis Disorders, Rich KA, Lim DJ (eds), 2005, House Ear Institute, Los Angeles
• Automated detection of ocular focusHunter DG, Nusz KJ, Gandhi NK, Quraishi IH, Gramatikov BI, Guyton DL. Automated detection of ocular focus. Journal Of Biomedical Optics 2004, 9: 1103-1109. PMID: 15447031, DOI: 10.1117/1.1781669.