Angeliki Louvi, PhD
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About
Titles
Professor of Neurosurgery and of Neuroscience
Deputy Director, MD-PhD ProgramBiography
Dr. Angeliki Louvi (Ph.D., Columbia University Medical Center, 1997) is Professor of Neurosurgery and of Neuroscience, Deputy Director of the MD-PhD Program, and member of the Yale Interdepartmental Neuroscience Program (INP) and the Yale Program on Neurogenetics. She is interested in understanding how the perturbation of basic biological processes leads to clinically significant brain pathology. Her laboratory investigates the cellular and molecular mechanisms underlying cerebrovascular and structural brain disorders associated with specific genetic lesions.
Appointments
Neurosurgery
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- University of Chicago (2004)
- Postdoctoral Fellow
- École normale supérieure (2001)
- PhD
- Columbia University Irving Medical Center, Genetics and Development (1997)
- BS
- University of Athens (1987)
Research
Overview
Cerebral Cavernous Malformations (CCM)
- Louvi, A.*, Chen, L., Two, A. M., Zhang, H., Min, W., and Günel, M.* (2011). Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology. Proc. Natl. Acad. Sci. USA. 108, 3737-3742. PMID: 21321212.
- Louvi, A.*, Nishimura, S. and Gunel, M. (2014). Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development, 141, 1404-1415. PMID: 24595293.
- Nishimura, S., Mishra-Gorur, K., Park, J., Surovtseva, Y., Sebti, S.M., Levchenko, A., Louvi, A.* and Gunel, M.* (2017). Combined HMG-CoA reductase and prenylation inhibition in treatment of CCM. Proceedings of the National Academy of Sciences USA. 114(21):5503-5508. doi: 10.1073/pnas.1702942114. PMID: 28500274.
- Peyre, M., Miyagishima, D., Bielle, F., Chapon, F., Sierant, M., Venot, Q., Lerond, J., Marijon, P., Abi-Jaoude, S., Le Van, T., Labreche, K., Houlston, R., Faisant, M., Clemenceau, S., Boch, A.-L., Nouet, A., Carpentier, A., Boetto, J., Louvi, A., Kalamarides, M. (2021) Recurrent Somatic PIK3CA mutations in Sporadic Cerebral Cavernous Malformations. New England Journal of Medicine 2021 Sep 9;385(11):996. doi: 10.1056/NEJMoa2100440. PMID: 34496175.
- Louvi, A., Nishimura, S., and Gunel, M. (2022). Genetics of Cerebral Cavernous Malformations. In Youmans and Winn’s Neurological Surgery, 8th edition, H. Richard Winn, Editor-in-Chief. Chapter 460, p.3760-3768.e6. Elsevier (Philadelphia, PA).
Structural Brain Disorders
- Bilgüvar, K.*, Oztürk, A. K.*, Louvi, A., Kwan, K. Y., Choi, M., Tatli, B., Yalnizoglu, D., Tüysüz, B., Caglayan, A. O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioglu, M., Yasuno, K., Ho, W., Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M. H., Bronen, R. A., Koçer, N., Per, H., Mane, S., Pamir, M. N., Yalçinkaya, C., Kumandas, S., Topçu, M., Ozmen, M., Sestan, N., Lifton, R. P., State, M. W., and Günel, M. (2010). Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 467, 207-210. PMID: 20729831.
- Sgourdou, P., Mishra-Gorur, K., Saotome, I., Henagariu, O., Tuysuz, B., Campos, C., Ishigame, K., Giannikou, K., Quon, J.L., Sestan, N., Caglayan, A.O., Gunel, M., and Louvi, A*. (2017) Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly. Scientific Reports 7:43708. doi: 10.1038/srep43708. PMID: 28272472.
- Dell’Amico, C., Angulo Salavarria, M.M., Takeo, Y., Saotome, I., Dell’Anno, M.T., Galimberti, M., Pellegrino, E., Cattaneo, E., Louvi, A.*, Onorati, M.* (2023) Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors. eLife Jun 5;12:e81716. doi: 10.7554/eLife.81716. PMID37272619.
Current Projects
- Cellular and Molecular Mechanisms of Structural Brain Disorders
- Biology and Pathobiology of Cerebral Cavernous Malformations
- Intracranial Aneurysms
Medical Subject Headings (MeSH)
Teaching & Mentoring
Teaching
Didactic INP 701: Principles of Neuroscience
Course DirectorLecture Setting9/1/2012 - PresentForGraduate40 Average Instructional Hours Per YearGeneral neuroscience seminar: lectures, readings, and discussion of selected topics in neuroscience. Emphasis is on how approaches at the molecular, cellular, physiological, and organismal levels can lead to understanding of neuronal and brain function.
Links & Media
News
- March 16, 2023
Discoveries & Impact (March 2023)
- January 27, 2021
Announcing Two New Associate Directors
- October 30, 2020
Juan Bartolomei, MD named Vice Chair of Diversity, Equity, and Inclusion
- June 01, 2017
Drug combo combats stroke, Yale researchers find