CORE's Previous Projects

Tele-HF is the largest randomized controlled trial to study the effectiveness of telemonitoring on heart failure outcomes.
The SAMI study defined how hospital organizational strategies may improve outcomes in patients following acute myocardial infarction.

In 2010, the National Heart, Lung, and Blood Institute of the National Institutes of Health established a Center for Cardiovascular Outcomes Research at Yale University, one of three identified after a national competition. CCOR’s 4-year grant will provide the research infrastructure to develop a national surveillance program for cardiovascular care and outcomes.

Women 55 years and younger have about twice the risk of death from a heart attack than similarly aged men. Our VIRGO group has been funded by the National Institutes of Health to examine predictors of a broad range of early and 1-year outcomes for young women with heart attacks and to examine such questions as: Do women get the same quality of care as men?

Hospitalomics, funded by a 4-year Donaghue Foundation grant, is a multi-disciplinary data-driven approach that combines systems thinking, outcomes sciences, and information sciences to generate information on variation in hospital care and to identify those patterns of care that are strongly associated with the best performance as measured by clinical outcomes (mortality and readmission rates) and hospital costs.

The Yale Collaboration to Optimize Medical Evidence and Transparency (COMET) Project was formed to serve as a trusted intermediary and provide transparent recommendations on clinical research design and medical product evidence generation. As an effort by academically-based clinical researchers, the Yale COMET Project operates independently of regulators, manufacturers and payers to serve the best interests of patients and the public, while respecting concerns of other stakeholders. An independent organization creates a separation from stakeholders that builds trust in the process, strengthens its integrity, and reduces opportunities for real or perceived influence. We provide fair and impartial assessments of what is needed to advance medical therapeutic and technology evaluation.