2024
Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?
Fernandes I, Stavres J, Hamaoka T, Ojikutu Q, Sabino-Carvalho J, Vianna L, Luck J, Blaha C, Cauffman A, Dalton P, Herr M, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults? Journal Of Neurophysiology 2024, 132: 922-928. PMID: 39110514, DOI: 10.1152/jn.00264.2024.Peer-Reviewed Original ResearchAdministration of amilorideArterial baroreflex sensitivityCardiac autonomic modulationBaroreflex sensitivityOral administrationBP variabilityBlood pressureOral administration of placeboAutonomic modulationSpontaneous cardiac baroreflexSympathetic arterial baroreflexAdministration of placeboIndices of BP variabilityMuscle sympathetic activitySympathetic baroreflex sensitivityHealthy young adultsPre-clinical modelsSingle oral administrationBlood pressure variabilityBeat-to-beat BPYoung adultsWeighted linear regression analysisHealthy young humansSympathetic baroreflexAmiloridePulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressureFurther innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34
Carr Z. Further innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34. Anesthesiology And Perioperative Science 2024, 2: 14. DOI: 10.1007/s44254-024-00053-7.Peer-Reviewed Original ResearchFurther innovation is required to enhance risk prediction of postoperative pulmonary complications
Carr, Z.J. Further innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34. APS 2, 14 (2024). https://doi.org/10.1007/s44254-024-00053-7Commentaries, Editorials and LettersEstimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population
Carr Z, Li J, Agarkov D, Gazura M, Karamchandani K. Estimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population. PLOS ONE 2024, 19: e0299137. PMID: 38394250, PMCID: PMC10889900, DOI: 10.1371/journal.pone.0299137.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsGastrointestinal endoscopic proceduresCongestive heart failurePropensity score matchingEndoscopic proceduresPulmonary complicationsSecondary outcomesPropensity score matching adjustmentRetrospective cohort studyRetrospective cohort analysisPulmonary circulatory disordersMultivariate logistic regressionAlcohol abuse disordersUpper endoscopic proceduresHealth system populationPulmonary emboliUpper endoscopyRespiratory failureLower endoscopyElectrolyte disordersHeart failureCohort studyConscious sedationPrimary outcomeCohort analysis
2023
Identifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review
Yan L, Karamchandani K, Gaiser R, Carr Z. Identifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review. Anesthesia & Analgesia 2023, 139: 68-77. PMID: 37874227, DOI: 10.1213/ane.0000000000006666.Peer-Reviewed Original ResearchPredictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset
Karamchandani K, Khorsand S, Ebeling C, Yan L, Nakonezny P, Carr Z. Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset. Journal Of Surgical Research 2023, 293: 482-489. PMID: 37827025, DOI: 10.1016/j.jss.2023.09.030.Peer-Reviewed Original ResearchConceptsPostoperative respiratory failurePredictors of failureDay of surgeryRespiratory failureNoncardiac surgeryNational Surgical Quality Improvement Project databaseSurgeons National Surgical Quality Improvement Project databaseMultiple logistic regression modelACS-NSQIP datasetsPreoperative prealbumin levelRetrospective cohort studyAnesthesiologists physical statusRetrospective cohort analysisLogistic regression modelsPreoperative ascitesPreoperative creatininePostoperative complicationsPrealbumin levelsCohort studyStudy cohortDisseminated cancerCohort analysisAmerican CollegePatientsPhysical statusAnesthesia for adult patients with asthma
Carr ZJ. Anesthesia for adult patients with asthma. UpToDate Aug 2023ChaptersPerioperative Pulmonary Complications in the Elderly The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Elderly The Forgotten System. Anesthesiology Clinics 2023, 41: 531-548. PMID: 37516493, DOI: 10.1016/j.anclin.2023.02.005.Peer-Reviewed Original ResearchEmergency use of sugammadex after failure of standard reversal drugs and postoperative pulmonary complications: A retrospective cohort study
Bruceta M, Singh P, Bonavia A, Carr Z, Karamchandani K. Emergency use of sugammadex after failure of standard reversal drugs and postoperative pulmonary complications: A retrospective cohort study. Journal Of Anaesthesiology Clinical Pharmacology 2023, 39: 232-238. PMID: 37564851, PMCID: PMC10410049, DOI: 10.4103/joacp.joacp_289_21.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsRetrospective cohort studyPulmonary complicationsNeuromuscular blockadeCohort studyReversal drugsMajor postoperative pulmonary complicationsTertiary care academic hospitalAdministration of neostigmineInpatient noncardiac surgeryNeostigmine/glycopyrrolateComposite primary outcomeUse of sugammadexComposite outcome measureNoncardiac surgeryAdult patientsPrimary outcomeGeneral anesthesiaProspective studyMedical recordsAcademic hospitalOutcome measuresSugammadexHigh incidenceComplicationsRecommendations for Intraoperative Adverse Events Data Collection in Clinical Studies and Study Protocols. An ICARUS Global Surgical Collaboration Study.
Cacciamani GE, Eppler M, Sayegh AS, Sholklapper T, Mohideen M, Miranda G, Goldenberg M, Sotelo RJ, Desai MM, Gill IS. Recommendations for Intraoperative Adverse Events Data Collection in Clinical Studies and Study Protocols. An ICARUS Global Surgical Collaboration Study. Int J Surg Protoc 2023, 27: 23-83. PMID: 36818424, DOI: 10.29337/ijsp.183.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInformation Technology-Enhanced Telehealth Consultations Reduce Preoperative Evaluation Center Visits in a Bariatric Surgery Population
Zafar J, Chan K, Ryder L, Duffy A, Dai F, Carr Z, Charchaflieh J. Information Technology-Enhanced Telehealth Consultations Reduce Preoperative Evaluation Center Visits in a Bariatric Surgery Population. Healthcare 2023, 11: 309. PMID: 36766884, PMCID: PMC9914614, DOI: 10.3390/healthcare11030309.Peer-Reviewed Original ResearchPreoperative evaluation centerPreoperative evaluation processDay of surgeryQuality of careBariatric surgery patientsPerson patient visitsSecondary outcomesSurgery patientsPrimary outcomePatient visitsBariatric surgery populationRetrospective cohort analysisAppropriate patient selectionPreoperative patient evaluationAcademic health systemAdditional testingSurgery populationPreoperative evaluationPatient selectionPatient evaluationCohort analysisPreoperative processCenter visitsTelehealth consultationsPatient carePerioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis
Carr Z, Yan L, Yanez N, Schonberger R, Bohorquez M, He Z, Li F, Hines R, Treggiari M. Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis. Medical Research Archives 2023, 11: 10.18103/mra.v11i10.4606. PMID: 38037571, PMCID: PMC10688569, DOI: 10.18103/mra.v11i10.4606.Peer-Reviewed Original ResearchMajor adverse cardiac eventsSystemic sclerosisLength of stayPerioperative complicationsSSc patientsComparative cohort analysisSSc cohortPerioperative outcomesControl cohortCohort analysisCormack-Lehane grade 3Limited cervical rangeAdverse cardiac eventsRare autoimmune disorderComparative cohort studySurgical site infectionBetween-group differencesQuaternary care institutionMultiple organ systemsHigh rateAirway complicationsComposite infectionHospital complicationsCardiac eventsCohort studyCannabis Use Disorder in Critical Illness.
Substance Use Disorders in Adult Critically Ill Patients. Chapter: Cannabis Use Disorder in Critical Illness. Springer Nature (in press, 2024)ChaptersPerioperative Pulmonary Complications in Geriatric Populations
Carr ZJ. Perioperative Pulmonary Complications in Geriatric Populations: A costly problem for healthcare systems. Asian Hospital & Healthcare Management. Issue 62, 2023 pp. 26-27Publications for non-academic audiences
2022
A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure
Stavres J, Luck J, Hamaoka T, Blaha C, Cauffman A, Dalton P, Herr MD, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure. AJP Regulatory Integrative And Comparative Physiology 2022, 323: r875-r888. PMID: 36222880, PMCID: PMC9678418, DOI: 10.1152/ajpregu.00190.2022.Peer-Reviewed Original ResearchConceptsBlood pressure indexTime-tension indexMean blood pressureBlood pressureAcid-sensing ion channelsDose of amilorideHealthy adultsOral doseIsometric plantar flexion exercisesVolume-matched placeboTotal exercise durationBlood pressure responseSingle oral doseHeart rate responsePlantar flexion exerciseBFR exerciseExercise tolerancePlacebo trialMuscle painExercise durationFlexion exercisePlantar flexionHeart ratePressure indexPainPerioperative Management of Patients with Idiopathic Pulmonary Fibrosis Undergoing Noncardiac Surgery: A Narrative Review
Carr ZJ, Yan L, Chavez-Duarte J, Zafar J, Oprea A. Perioperative Management of Patients with Idiopathic Pulmonary Fibrosis Undergoing Noncardiac Surgery: A Narrative Review. International Journal Of General Medicine 2022, 15: 2087-2100. PMID: 35237071, PMCID: PMC8882471, DOI: 10.2147/ijgm.s266217.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIdiopathic pulmonary fibrosisInterstitial lung diseaseIdiopathic interstitial pneumoniaIPF patientsNarrative reviewPerioperative managementHome oxygen useSafe perioperative carePostoperative pulmonary complicationsRetrospective cohort studyCardiopulmonary exercise testingOptimal perioperative managementPreoperative risk stratificationPulmonary function studiesWeb of ScienceAcute exacerbationARISCAT scorePostoperative pneumoniaPulmonary complicationsNoncardiac surgerySurgical populationCohort studyExercise testingInterstitial pneumoniaNeuraxial anesthesiaMinimally Invasive Esophagectomy
▪ Carr Z. Minimally Invasive Esophagectomy. In Video Atlas of Upper and Lower Airway Management, 2nd edition, ed. Rosenblatt W, Popescu W, Ginsberg N. Lippincot, Williams & Wilkins (LWW)ChaptersPheochromocytoma and MEN Syndromes
▪ Carr Z, Farela A, Oprea AD. Pheochromocytoma and MEN syndromes. In Perioperative Medicine: A Problem Based Learning Approach, ed. D. Richman, D. Pulley, A.D. Oprea. Oxford University PressChapters
2021
Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity
Yan L, Bohorquez MA, Carr ZJ. Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity. A&A Practice 2021, 15: e01537. PMID: 34695040, DOI: 10.1213/xaa.0000000000001537.Peer-Reviewed Case Reports and Technical NotesConceptsIntravesical adjuvant therapyPulmonary embolic phenomenaTreatment of patientsPotential adverse eventsPostoperative vasoplegiaRobotic nephroureterectomyVasopressor supportAdjuvant therapyPostoperative courseAdverse eventsEmbolic phenomenaSupportive managementResuscitative effortsAllergic reactionsCommon causeVasoplegiaGemcitabine toxicityGemcitabinePatientsUreteronephrectomyNephroureterectomyBleedingTherapyInfection