2019
A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones
Ren Y, He Y, Brown S, Zbornik E, Mlodzianoski M, Ma D, Huang F, Mattoo S, Suter D. A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones. Molecular Biology Of The Cell 2019, 30: 1817-1833. PMID: 31116646, PMCID: PMC6727743, DOI: 10.1091/mbc.e18-04-0202.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylation sitesPhosphorylation sitesFilopodia formationNeuronal growth conesSingle tyrosine phosphorylation sitePhosphorylated cortactinGrowth conesPhospho-mimetic mutantVitro kinase assaysFilopodia lengthFunction of cortactinTyrosine-phosphorylated cortactinFormation of filopodiaSrc tyrosine kinaseCortactin mutantMultiple actinPhosphorylation substratesActin organizationCellular processesLength of filopodiaKinase assaysCortactinTyrosine kinaseNonneuronal cellsFilopodia
2018
A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D
Ren Y, Mlodzianoski M, Lee A, Huang F, Suter D. A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D. Journal Of Neural Engineering 2018, 15: 035001. PMID: 29363623, PMCID: PMC6040821, DOI: 10.1088/1741-2552/aaaa32.Peer-Reviewed Original Research
2016
Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate
Ren Y, Suter D. Increase in Growth Cone Size Correlates with Decrease in Neurite Growth Rate. Neural Plasticity 2016, 2016: 3497901. PMID: 27274874, PMCID: PMC4870373, DOI: 10.1155/2016/3497901.Peer-Reviewed Original Research
2015
Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones
He Y, Ren Y, Wu B, Decourt B, Lee A, Taylor A, Suter D. Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones. Molecular Biology Of The Cell 2015, 26: 3229-3244. PMID: 26224308, PMCID: PMC4569314, DOI: 10.1091/mbc.e15-03-0142.Peer-Reviewed Original ResearchConceptsActin network densityGrowth conesSrc tyrosine kinaseFluorescent speckle microscopyState of actinNeuronal growth conesGrowth cone motilityLamellipodia protrusionActin organizationActin assemblyFilopodia formationActin bundlesAplysia growth conesSpeckle microscopyTyrosine kinaseUnderlying cellular mechanismsFilopodial densityCone motilityCellular mechanismsSrcFilopodiaActivation stateLamellipodiaSRC2Axonal growth
2012
Gekko-sulfated Glycopeptide Inhibits Tumor Angiogenesis by Targeting Basic Fibroblast Growth Factor*
Zhang S, Zhu C, Ba Y, Chen D, Zhou X, Cao R, Wang L, Ren Y, Wu X. Gekko-sulfated Glycopeptide Inhibits Tumor Angiogenesis by Targeting Basic Fibroblast Growth Factor*. Journal Of Biological Chemistry 2012, 287: 13206-13215. PMID: 22371501, PMCID: PMC3340002, DOI: 10.1074/jbc.m111.321521.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularChick EmbryoChickensDrug DiscoveryDrugs, Chinese HerbalEarly Growth Response Protein 1Fibroblast Growth Factor 2GlucuronidaseHep G2 CellsHeparinHuman Umbilical Vein Endothelial CellsHumansLiver Neoplasms, ExperimentalMaleMiceMice, NudeNeovascularization, PathologicPolysaccharidesSurface Plasmon ResonanceXenograft Model Antitumor AssaysConceptsBasic fibroblast growth factorFibroblast growth factorTumor angiogenesisProduction of bFGFEndothelial cellsGrowth factorGekko swinhonis GuentherAbsence of bFGFInhibits tumor angiogenesisXenograft mouse modelLow-affinity receptorsEarly growth response 1Traditional Chinese medicineRelease of bFGFHeparan sulfateMouse modelTherapeutic targetHeparanase enzymatic activityTumor growthBFGF productionHeparin/heparan sulfateAffinity receptorInhibitory effectChinese medicineExtracellular matrix
2011
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner
Li D, Xie S, Ren Y, Huo L, Gao J, Cui D, Liu M, Zhou J. Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2: 150-160. PMID: 21359602, PMCID: PMC4875255, DOI: 10.1007/s13238-011-1015-4.Peer-Reviewed Original ResearchConceptsHistone deacetylase 6Molecular mechanismsCell migrationEB1-dependent mannerEndothelial cell migrationCell motilityNovel playerCapillary-like structuresEndothelial cellsEndothelial tube formationNew capillary vesselsCell polarizationHDAC6 activityMicrotubule endsNew blood vesselsNovel insightsProtein 1Vascular endothelial cellsTube formationBlood vasculatureCapillary sproutingAngiogenic processChick embryosAngiogenesisImportant process