2024
Structural insights into PPP2R5A degradation by HIV-1 Vif
Hu Y, Delviks-Frankenberry K, Wu C, Arizaga F, Pathak V, Xiong Y. Structural insights into PPP2R5A degradation by HIV-1 Vif. Nature Structural & Molecular Biology 2024, 31: 1492-1501. PMID: 38789685, DOI: 10.1038/s41594-024-01314-6.Peer-Reviewed Original ResearchHost-virus protein interactionsCullin RING E3 ubiquitin ligasesInduced G2/M cell cycle arrestSets of proteinsG2/M cell cycle arrestSubstrate-binding siteCryogenic-electron microscopy structuresProtein phosphatase 2ADegradation-independent mechanismCell cycle arrestUbiquitin ligaseProtein interactionsPhosphatase 2AAntiviral proteinCycle arrestDegradation-dependentA-resolutionHIV-1 VifPPP2R5AStructural insightsDiverse interactionsProteinCellular studiesPhosphatase activityPotential target
2012
Structural insights into the function of FANCM‐mediated complexes
Saro D, Sachpatzidis A, Zheng X, Singh T, Meetei A, Xiong Y, Sung P. Structural insights into the function of FANCM‐mediated complexes. The FASEB Journal 2012, 26: 536.8-536.8. DOI: 10.1096/fasebj.26.1_supplement.536.8.Peer-Reviewed Original ResearchCore complex proteinsComplex proteinsDNA bindingDNA damage-induced monoubiquitinationFA-BRCA pathwayBranch migration activityProtein-protein interactionsDNA damage responseHigh-resolution crystal structuresResolution crystal structureChromatin localizationNovel histoneDamage responseSensitivity of cellsFANCMStructural insightsBiochemical characterizationFoci formationProteinStructural workX-ray crystallographyChromosome aberrationsMigration activityFunctional integrityComplexes