2023
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell G, Yang R, Aiken C, Engelman A, Lusk C, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nature Structural & Molecular Biology 2023, 30: 425-435. PMID: 36807645, PMCID: PMC10121901, DOI: 10.1038/s41594-023-00925-9.Peer-Reviewed Original ResearchConceptsNuclear pore complexHIV-1 nuclear entryNuclear entryNuclear importNPC central channelPore complexHost nucleusCapsid dockingVirus genomeAffinity gradientNup153Central channelMechanistic insightsMolecular interactionsCapsidNucleoporinsNup358Nup62GenomeNucleusVirusDockingVirus-1 infectionImportComplexes
2020
Cryo-EM Structure of Monomeric Photosystem II from Synechocystis sp. PCC 6803 Lacking the Water-Oxidation Complex
Gisriel C, Zhou K, Huang H, Debus R, Xiong Y, Brudvig G. Cryo-EM Structure of Monomeric Photosystem II from Synechocystis sp. PCC 6803 Lacking the Water-Oxidation Complex. Joule 2020, 4: 2131-2148. DOI: 10.1016/j.joule.2020.07.016.Peer-Reviewed Original ResearchOxygen-evolving complexPhotosystem II enzymeWater oxidation complexWater oxidationMetal clustersMechanism of photoactivationActive siteMonomeric photosystem IIPhotosystem IICryo-EM structureStructural rearrangementsComplexesPhotoactivationSynechocystis spPeripheral subunitsCationsComputational techniquesOxidationOverall biogenesisStructureMesophilic cyanobacteriumOxygenPCC 6803II enzymesPSII
2012
Structural insights into the function of FANCM‐mediated complexes
Saro D, Sachpatzidis A, Zheng X, Singh T, Meetei A, Xiong Y, Sung P. Structural insights into the function of FANCM‐mediated complexes. The FASEB Journal 2012, 26: 536.8-536.8. DOI: 10.1096/fasebj.26.1_supplement.536.8.Peer-Reviewed Original ResearchCore complex proteinsComplex proteinsDNA bindingDNA damage-induced monoubiquitinationFA-BRCA pathwayBranch migration activityProtein-protein interactionsDNA damage responseHigh-resolution crystal structuresResolution crystal structureChromatin localizationNovel histoneDamage responseSensitivity of cellsFANCMStructural insightsBiochemical characterizationFoci formationProteinStructural workX-ray crystallographyChromosome aberrationsMigration activityFunctional integrityComplexes