Featured Publications
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficitsSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionNicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine actsDesigning Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction
Zakiniaeiz Y, Cosgrove KP. Designing Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction. Biological Psychiatry 2020, 88: 741-743. PMID: 33092691, PMCID: PMC11265605, DOI: 10.1016/j.biopsych.2020.08.011.Peer-Reviewed Original ResearchBalance of the Sexes: Addressing Sex Differences in Preclinical Research.
Zakiniaeiz Y, Cosgrove KP, Potenza MN, Mazure CM. Balance of the Sexes: Addressing Sex Differences in Preclinical Research. The Yale Journal Of Biology And Medicine 2016, 89: 255-9. PMID: 27354851, PMCID: PMC4918870.Peer-Reviewed Original ResearchCingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differencesAltered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents
Zakiniaeiz Y, Yip SW, Balodis IM, Lacadie CM, Scheinost D, Constable RT, Mayes LC, Sinha R, Potenza MN. Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents. Drug And Alcohol Dependence 2017, 180: 129-136. PMID: 28888152, PMCID: PMC5808433, DOI: 10.1016/j.drugalcdep.2017.07.030.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureNeutral-relaxing conditionsPCE adolescentsParietal connectivityConnectivity analysisSensory areasAdolescent brain functionFunctional magnetic resonance imagingCue interaction effectsIntrinsic connectivity analysesMedial prefrontal areasSeed-based connectivity analysisSubstance Use InitiationAltered functional connectivityAppetitive cuesObesity vulnerabilityPCE statusNeural responsesCorticolimbic connectivityPrefrontal areasFunctional connectivityCraving scoresUtero drug exposureGroup differencesLess connectivityDoes Telescoping Exist in Male and Female Gamblers? Does It Matter?
Zakiniaeiz Y, Cosgrove KP, Mazure CM, Potenza MN. Does Telescoping Exist in Male and Female Gamblers? Does It Matter? Frontiers In Psychology 2017, 8: 1510. PMID: 28928697, PMCID: PMC5591942, DOI: 10.3389/fpsyg.2017.01510.Peer-Reviewed Original ResearchToward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex
Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex. Brain Imaging And Behavior 2017, 13: 314-322. PMID: 29071465, PMCID: PMC5918462, DOI: 10.1007/s11682-017-9779-7.Peer-Reviewed Original ResearchConceptsDA releaseDA receptorsDA changesCortical DA releaseMesocorticolimbic dopamine circuitRecent PET studiesPositron emission tomography (PET) radiotracerMesocortical DA pathwaysMesocortical systemCigarette smokingDA pathwayDA transmissionMesolimbic pathwayDopamine transmissionMesocortical DAWhole brainDopamine circuitsNovel high affinityTomography radiotracerPET studiesPET dataStriatumPET imagingEffects of stressCortexMechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use
Lichenstein SD, Zakiniaeiz Y, Yip SW, Garrison KA. Mechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use. Current Addiction Reports 2019, 6: 114-125. PMID: 32864292, PMCID: PMC7451029, DOI: 10.1007/s40429-019-00245-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNicotine useClinical featuresCholinergic systemUse disordersOpioid use disorderPurpose of ReviewToSubstance use disordersSex/gender considerationsRecent FindingsOpioidPathophysiological mechanismsSmoking cessationRisk factorsTreatment outcomesDrug rewardOpioidsFurther studiesHigh rateTreatmentDisordersHighlight areasPainReviewToEtiologyPharmacologicalCessationSex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokersLicit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019)
Peltier MR, Roberts W, Verplaetse TL, Burke C, Zakiniaeiz Y, Moore K, McKee SA. Licit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019). Archives Of Women's Mental Health 2022, 25: 819-827. PMID: 35737132, PMCID: PMC9359119, DOI: 10.1007/s00737-022-01244-6.Peer-Reviewed Original ResearchConceptsPast-month substance useFirst trimesterPast-year substance usePregnant womenIllicit substance useDrug useSubstance useThird trimesterCross-sectional population-based dataSignificant public health concernTrimester of pregnancyPrescription pain medicationPopulation-based dataPerinatal substance useIllicit drug useMethodsThe present studyPublic health concernMinority of womenNational surveyLicit substance usePain medicationSimilar low ratesSecond trimesterLate trimesterLicit substancesUsing machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst monthHarmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects
Hoye J, Toyonaga T, Zakiniaeiz Y, Stanley G, Hampson M, Morris ED. Harmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects. EJNMMI Physics 2022, 9: 27. PMID: 35416555, PMCID: PMC9008103, DOI: 10.1186/s40658-022-00457-z.Peer-Reviewed Original ResearchHuman subjectsNon-displaceable binding potentialPET imaging studiesTest-retest variabilityHarmonization studyStriatal BPNDPercent differenceImaging studiesResultsExperiment 1Inter-scanner variabilityBrain PET imagesBPND estimatesSubjectsOngoing needPET imagesRT variabilityBinding potentialPD resultsBackgroundThereBPNDRTSex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders
Peltier MR, Roberts W, Verplaetse TL, Zakiniaeiz Y, Burke C, Moore KE, McKee SA. Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders. Journal Of Dual Diagnosis 2021, 18: 11-20. PMID: 34965199, PMCID: PMC9086923, DOI: 10.1080/15504263.2021.2016027.Peer-Reviewed Original ResearchConceptsDrug use disordersOngoing posttraumatic stress disorderSubstance use disordersSUD/PTSDPosttraumatic stress disorderNew PTSD diagnosisImpact of sexUse disordersDiagnosis of SUDPast-year substance use disorderPTSD diagnosisConcurrent substance use disordersDiagnosis of PTSDPoor treatment outcomesNational Epidemiologic SurveyBidirectional relationshipSex-specific analysesPotential sex-specific differencesTreatment outcomesGender-related differences in addiction: a review of human studies
Zakiniaeiz Y, Potenza M. Gender-related differences in addiction: a review of human studies. Current Opinion In Behavioral Sciences 2018, 23: 171-175. DOI: 10.1016/j.cobeha.2018.08.004.Peer-Reviewed Original ResearchLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed recallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signalingThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanoloneDiagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder
Zakiniaeiz Y, Lacadie C, Macdonald-Gagnon G, DeVito E, Potenza M. Diagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder. Drug And Alcohol Dependence 2023, 251: 110962. PMID: 37716288, PMCID: PMC10557108, DOI: 10.1016/j.drugalcdep.2023.110962.Peer-Reviewed Original ResearchConceptsCocaine use disorderCognitive controlStroop performanceIntrinsic connectivityStroop task performanceFMRI Stroop taskDiagnostic groupsUse disordersDiagnostic group differencesMain effectHealthy comparison subjectsStroop effectStroop taskBehavioral resultsTask performanceFrontal gyrusIntrinsic connectivity distributionPrefrontal cortexAuditory areasGroup differencesBrain connectivityCingulate gyrusStroopBehavioral differencesHC groupSex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive component