2012
Nuclear localization of Klotho in brain: an anti-aging protein
German D, Khobahy I, Pastor J, Kuro-o M, Liu X. Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiology Of Aging 2012, 33: 1483.e25-1483.e30. PMID: 22245317, PMCID: PMC3328593, DOI: 10.1016/j.neurobiolaging.2011.12.018.Peer-Reviewed Original ResearchConceptsExtracellular domainNuclear membraneSingle-pass transmembrane proteinMultiple fibroblast growth factor receptorsFibroblast growth factor receptorNuclear functionsPrecise cellular localizationTransmembrane proteinGrowth factor receptorNuclear localizationPlasma membraneTransmembrane formCellular localizationCell typesCultured cellsAnti-aging proteinCell membraneImmunoelectron microscopyLigand affinityWhole animalFactor receptorAntioxidant enzymesProteinKlotho proteinGenes
2001
Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis
Sugita S, Han W, Butz S, Liu X, Fernández-Chacón R, Lao Y, Südhof T. Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis. Neuron 2001, 30: 459-473. PMID: 11395007, DOI: 10.1016/s0896-6273(01)00290-2.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlternative SplicingAmino Acid SequenceAnimalsAnimals, NewbornBrainCalciumCalcium-Binding ProteinsCell MembraneCloning, MolecularEmbryo, MammalianExocytosisExonsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsLuminescent ProteinsMaleMembrane GlycoproteinsMiceMolecular Sequence DataNerve Tissue ProteinsOrgan SpecificityPC12 CellsRatsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidSynapsesSynaptotagminsTransfectionConceptsSynaptotagmin VIIPlasma membraneNeuroendocrine PC12 cellsSynaptic vesiclesSynaptic vesicle exocytosisPlasma membrane Ca2Presynaptic active zoneVesicle exocytosisSynaptic exocytosisDependent exocytosisCentral synapsesRegulated patternSynaptotagmin IExocytosisMembrane Ca2SynaptotagminFusion partnerPC12 cellsNeuroendocrine cellsNeurotransmitter releasePotent inhibitorVesiclesActive zoneMembraneCells