Featured Publications
TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity
Fu W, Hu W, Yi Y, Hettinghouse A, Sun G, Bi Y, He W, Zhang L, Gao G, Liu J, Toyo-oka K, Xiao G, Solit D, Loke P, Liu C. TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity. Journal Of Clinical Investigation 2021, 131 PMID: 34185706, PMCID: PMC8363273, DOI: 10.1172/jci144016.Peer-Reviewed Original ResearchConceptsMacrophage polarizationMacrophage plasticityPI3K/Akt/mTORPathogenesis of inflammationMyeloid-specific deletionNF-κB activationAkt/mTORInflammatory arthritisAntiinflammatory pathwayImmunoregulatory roleAutoimmune diseasesProtective effectTherapeutic implicationsInflammationTNFR2 signalingAutoimmunityTNFR2TNFR2 activationReceptor complexDiseaseIntracellular regulatorsActivationMolecule 14TNFR1Arthritis
2023
Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice
Chen M, Fu W, Xu H, Liu C. Tau deficiency inhibits classically activated macrophage polarization and protects against collagen-induced arthritis in mice. Arthritis Research & Therapy 2023, 25: 146. PMID: 37559125, PMCID: PMC10410869, DOI: 10.1186/s13075-023-03133-4.Peer-Reviewed Original ResearchConceptsInflammatory cell infiltrationPro-inflammatory cytokinesRheumatoid arthritisAnkle jointSerum levelsCell infiltrationMacrophage polarizationOsteoclast activityCartilage damagePathogenesis of RACollagen-induced arthritis modelTau-/- miceCollagen-induced arthritisInflammatory joint diseasePro-inflammatory functionsProgression of CIAPotential therapeutic targetRole of tauInflammatory arthritisBone erosionArthritis incidenceBone lossClinical scoresArthritis modelInflammatory disorders
2018
THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis
Fu W, Hettinghouse A, Liu C. THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis. Annals Of The Rheumatic Diseases 2018, 77: 252. DOI: 10.1136/annrheumdis-2018-eular.4729.Peer-Reviewed Original ResearchAnti-inflammatory actionTNF receptor 2Mean fluorescence intensityAnti-inflammation actionClinical arthritis scoreInflammatory arthritisCIA miceAnti-inflammatory effectsAnti-inflammatory activityMacrophage polarizationProtective effectArthritis scoreCritical downstream mediatorM2 polarizationΔ miceM1-M2 polarizationPresence of progranulinAnti-inflammatory pathwaySeverity of CIADownstream mediatorSignificant decreasePercentage of CD206Hallmarks of macrophagesPGRN effectsWT mice