2024
Blood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target?
Harper L, Kuo H, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Galis Z, Ambalavanan N, Oparil S, Szychowski J, Tita A. Blood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target? American Journal Of Obstetrics And Gynecology 2024 PMID: 39288828, DOI: 10.1016/j.ajog.2024.09.006.Peer-Reviewed Original ResearchTarget blood pressureNeonatal intensive care unitLow blood pressure groupBlood pressure groupPerinatal outcomesAverage blood pressureChronic hypertensionMm HgBlood pressureCesarean deliveryNeonatal deathDiastolic BPRisk of NICU admissionCompare perinatal outcomesEvaluate risk ratiosLt;130/80 mm HgPreterm birth <Adverse perinatal outcomesMultivariable log-binomial regression modelsGoal blood pressureAverage diastolic BPPrimary composite outcomeSystolic BP <Log-binomial regression modelsAntenatal blood pressure
2023
Community-level social determinants of health and pregestational and gestational diabetes
Field C, Grobman W, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Venkatesh K. Community-level social determinants of health and pregestational and gestational diabetes. American Journal Of Obstetrics & Gynecology MFM 2023, 6: 101249. PMID: 38070680, PMCID: PMC11184512, DOI: 10.1016/j.ajogmf.2023.101249.Peer-Reviewed Original ResearchCommunity-level social determinantsGestational diabetesPregestational diabetesAdverse social determinantsSocial determinantsSocioeconomic disadvantageNulliparous Pregnancy Outcomes StudyGestational diabetes diagnosisArea deprivation index scoreMedicaid insurance statusRisk of diabetesPregnancy Outcomes StudyWalkable neighborhoodsDeprivation index scoreArea Deprivation IndexLower household incomeFood desertsGreater socioeconomic disadvantageChronic hypertensionHighest tertileFirst trimesterHigher socioeconomic disadvantageInsurance statusMonitoring MothersMultinomial logistic regressionRisk Factors, Trends, and Outcomes Associated With Postpartum Sepsis Readmissions
Liu L, Wen T, Reddy U, Mourad M, Goffman D, Nathan L, Sheen J, D'Alton M, Friedman A. Risk Factors, Trends, and Outcomes Associated With Postpartum Sepsis Readmissions. Obstetrics And Gynecology 2023, 143: 346-354. PMID: 37944152, DOI: 10.1097/aog.0000000000005437.Peer-Reviewed Original ResearchPostpartum readmissionDelivery hospitalizationsSepsis readmissionsJoinpoint Regression ProgramAdverse outcomesSepsis diagnosisSevere morbidityAssociated diagnosisRisk factorsNational Cancer Institute's Joinpoint Regression ProgramAverage annual percent changeRetrospective cohort studyClinical risk factorsNationwide Readmissions DatabaseMedian ZIP code incomeAdjusted odds ratioChronic medical conditionsIntra-amniotic infectionAnnual percent changeZip code incomeLogistic regression modelsChronic hypertensionMaternal sepsisPregestational diabetesCohort studySodium intake and the development of hypertensive disorders of pregnancy
Bank T, Grasch J, Chung J, Mercer B, McNeil R, Parry S, Saade G, Shanks A, Silver R, Simhan H, Yee L, Reddy U, Grobman W, Frey H. Sodium intake and the development of hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101166. PMID: 37741626, DOI: 10.1016/j.ajogmf.2023.101166.Peer-Reviewed Original ResearchConceptsHypertensive disordersHigh sodium intakeSodium intakeChronic hypertensionNonpregnant populationLow platelet count syndromeNeonatal intensive care unitNulliparous Pregnancy Outcomes StudyElevated liver enzymesGestational age neonatesFood frequency questionnaireLow sodium intakeIncidence risk ratioIntensive care unitWeeks of gestationPregnancy Outcomes StudyLack of associationChi-square testGestational hypertensionNeonatal outcomesNonpregnant stateSodium restrictionFrequency questionnairePreterm birthSingleton pregnanciesAssociation between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
Delgado A, Kendle A, Randis T, Donda K, Salemi J, Facco F, Parker C, Reddy U, Silver R, Basner R, Chung J, Schubert F, Pien G, Redline S, Parry S, Grobman W, Zee P, Louis J. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals. American Journal Of Perinatology 2023, 41: e2418-e2426. PMID: 37380034, DOI: 10.1055/a-2115-0147.Peer-Reviewed Original ResearchSleep-disordered breathingAdverse neonatal outcomesNeonatal outcomesPrimary outcomeRisk ratioApnea-hypopnea indexRespiratory distress syndromeBody mass indexEvents/hConfidence intervalsSleep Disordered BreathingLog-binomial regressionNulliparous individualsHome sleep studiesChronic hypertensionNeonatal morbidityNew onsetPregestational diabetesComposite outcomeRespiratory supportTransient tachypneaDistress syndromeGestational ageMass indexMaternal riskBreastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial
Goulding A, Antoniewicz L, Leach J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Harper L, Ambalavanan N, Oparil S, Szychowski J, Tita A, Consortium C. Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101086. PMID: 37437694, PMCID: PMC10528420, DOI: 10.1016/j.ajogmf.2023.101086.Peer-Reviewed Original ResearchConceptsDuration of breastfeedingChronic hypertensionMild chronic hypertensionPostpartum clinic visitPostpartum study visitsGoal blood pressureBlood pressure measurementsPostpartum visitTreatment groupsBlood pressureBreastfeeding outcomesPregnancy trialSecondary analysisClinic visitsBreastfeeding goalsStudy visitBlood pressure treatment strategiesLong-term breastfeeding outcomesBivariate analysisMaternal cardiovascular healthActive treatment groupBlood pressure controlEarlier gestational ageHigh-risk populationWeeks of breastfeedingHypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers
Battarbee A, Mele L, Landon M, Varner M, Casey B, Reddy U, Wapner R, Rouse D, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S. Hypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers. American Journal Of Perinatology 2023, 41: e1976-e1981. PMID: 37201538, PMCID: PMC10755076, DOI: 10.1055/a-2096-0443.Peer-Reviewed Original ResearchBaseline body mass indexHypertensive disordersGestational hypertensionCardiovascular biomarkersHigher baseline blood pressureLow GDF-15 levelsAssociation of HDPPresence of HDPGDF-15 levelsBaseline blood pressureHomeostatic model assessmentBody mass indexStudy of patientsSerum insulin concentrationsLongitudinal studyMultivariable linear regressionChronic hypertensionGDM cohortPregnancy hypertensionGDF-15Insulinogenic indexPostpartum interventionsBlood pressureMass indexCardiovascular dysfunctionMaternal Morbidity Risk Factors in Nulliparas
Merriam A, Metz T, Allshouse A, Silver R, Haas D, Grobman W, Simhan H, Wapner R, Wing D, Mercer B, Parry S, Reddy U, Investigators +. Maternal Morbidity Risk Factors in Nulliparas. American Journal Of Perinatology 2023, 41: e1878-e1884. PMID: 37150178, DOI: 10.1055/a-2088-2586.Peer-Reviewed Original ResearchVenous thromboembolic eventsSelf-identified black raceComposite maternal morbidityPrimary maternal outcomeSevere maternal morbidityMaternal morbidityChronic kidney diseaseBlack raceRisk factorsChronic hypertensionHypertensive disordersMaternal outcomesPregestational diabetesKidney diseaseMedical conditionsMulticenter prospective observational cohortPrepregnancy body mass indexPreexisting medical comorbiditiesPrior obstetric historyProspective observational cohortMorbidity risk factorsBody mass indexMultiple risk factorsDays of deliveryLog-binomial regressionShort-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2022
Treatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 634-636. DOI: 10.1097/01.ogx.0000899456.24100.71.Peer-Reviewed Original ResearchHypertension During PregnancyAcute kidney injuryAdverse neonatal outcomesChronic hypertensionKidney injuryMaternal outcomesNeonatal outcomesPlacental abruptionPreterm birthHeart failureMaternal deathsGestational agePerinatal deathPulmonary edemaPregnancyBlack womenDeathOutcomesHypertensionAbruptionPreeclampsiaEdemaInjuryStrokeWomenTreatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 460-462. DOI: 10.1097/01.ogx.0000852888.79526.c3.Peer-Reviewed Original Research
2021
Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortality
2020
Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009)
College of Obstetricians and Gynecologists A, with S, Metz TD, Berry RS, Fretts RC, Reddy UM, Turrentine MA. Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009). American Journal Of Obstetrics And Gynecology 2020, 222: b2-b20. PMID: 32004519, DOI: 10.1016/j.ajog.2020.01.017.Peer-Reviewed Original ResearchObstetric historyCommon adverse pregnancy outcomesNon-Hispanic black raceMaternal obstetric historyObstetric Care ConsensusAdverse pregnancy outcomesPast obstetric historyPrevalent risk factorsMale fetal sexAdvanced maternal ageTiming of deliveryHealth care providersPeer support groupsMental health professionalsChronic hypertensionMultiple gestationsPregnancy outcomesGestational ageBlack raceMaternal ageRisk factorsDefinite causeUnmarried statusHistologic examinationUmbilical cord
2011
Prepregnancy Risk Factors for Antepartum Stillbirth in the United States
Reddy U, Laughon S, Sun L, Troendle J, Willinger M, Zhang J. Prepregnancy Risk Factors for Antepartum Stillbirth in the United States. Obstetrical & Gynecological Survey 2011, 66: 69-70. DOI: 10.1097/ogx.0b013e31821686c6.Peer-Reviewed Original ResearchPrepregnancy risk factorsAntepartum stillbirthBody mass indexRisk factorsAdvanced maternal ageChronic hypertensionTerm stillbirthMaternal ageMass indexPrepregnancy body mass indexLive birth controlsRisk of stillbirthWeeks of gestationAfrican American racePotential risk factorsIndividual risk factorsYears of ageAdjusted riskAntenatal surveillanceCesarean deliveryPreterm birthSingleton pregnanciesPreexisting diabetesTerm deliveryNormal weight